art_primary_dryad

Dataset containing all ART data from those individuals included in the primary analysis investigating time from HIV seroconversion to HIV disease progression

cd4_data_decline_dryad

Dataset containing all CD4 data from individuals included in the analysis investigating CD4 cell decline following HCV infection

baseline_characteristics_decline_dryad

Dataset containing relevant baseline characteristics for those individuals included in the analysis investigating CD4 cell decline following HCV infection

Novel methods for 18F-radiolabelling

<p>The expansion of [¹⁸F]-radiolabelling methodologies is vital for the advancement of Positron Emission Tomography (PET) as a medical imaging tool. Novel protocols will simplify access to current PET tracers and allow development of original tracers, potentially enhancing the imaging quality or permit imaging of a wider range of clinical problems. A general introduction is presented in <b>Chapter 1</b>, covering PET, application of fluorine-19 in the pharmaceutical industry, the production of fluorine-18 and the current state-of -art for [¹⁸F]-radiolabelling. </p> <p>The results chapters are divided in to two parts; <b>Part 1</b> (<b>Chapters 2 - 4</b>) concern the synthesis of [18F]fluoroarenes and <b>Part II</b> (<b>Chapters 5</b> and <b>6</b>) discuss diversity oriented radiofluorination techniques, targeting novel [¹⁸F]motifs.</p> <p>In <b>Part I</b>, Chapter 2 describes the use of hypervalent iodine reagents to meditate an umpolung approach for fluorination and radiofluorination of N-arylsulfonamides and anilides. <b>Chapter 3</b> again utilises hypervalent iodine reagents, but as spirocyclic iodonium(III) ylide precursors, being applied to semi-automated and automated microfluidic conditions. <b>Chapter 4</b> discusses the development of conditions for the production and isolation of radiopharmaceuticals employing Cu(II)-mediated radiofluorination of aryl boronic pinacol esters.</p> <p>In <b>Part II, Chapter 5</b> discusses the applicability of halogen exchange reactions to reach polyfluorinated motfis and <b>Chapter 6</b> focuses on the application of a single diazo precursor to access three polyfluorinated motifs with single-step reactions.</p> <p>Finally, <b>Chapter 7</b> provides experimental data for compounds discussed in this thesis.</p

hcv_data_response_dryad

Dataset containing all HCV data for those individuals included in the analysis investigating CD4 response to cART

hcv_data_decline_dryad

Dataset containing all HCV data for those individuals included in the analysis investigating CD4 cell decline following HCV infection

deaths_primary_dryad

Dataset containing all mortality data from those individuals included in the primary analysis investigating time from HIV seroconversion to HIV disease progression

hcv_data_primary_dryad

Dataset containing all HCV data from those individuals included in the primary analysis investigating time from HIV seroconversion to HIV disease progression

art_response_dryad

Dataset containing all ART data from individuals included in the analysis investigating CD4 response to cART

cd4_data_response_dryad

Dataset containing all CD4 data from individuals included in the analysis investigating CD4 response to cART