Optimization of Process Parameters for CNC Turning using Taguchi Methods for EN24 Alloy Steel with Coated/Uncoated Tool Inserts

Coated and uncoated tool inserts offers certain degrees of control on the desired rate of tool wear and surface roughness to an extent. This work pursues the quest for realizing the optimal values for the significant process parameters that bears an influence on the response parameters. Experiments were conducted on the samples of EN 24 alloy steel material with the help of PVD coated TiAlN insert and uncoated carbide insert. The experimental runs carried out with proper variation in the levels. Levels are selected with the help of manufacturing catalogue and by pilot experimentation and results are recorded for further analysis. For this study, 9 runs designed using L9 orthogonal array of Taguchi Design of Experiment. Surface roughness was measured using a Mitutoyo surface tester at test lab and material removal rate is calculated by mathematical equation. The data was compiled into Minitab 17 software for analysis. The relationship between the machining parameters and the response variables were analyzed using the Taguchi Method. Optimization of process parameters is carried out by Grey Relational Analysis method (GRA). GRA method is a powerful and most versatile tool which can manipulate the input data as per requirement and comes with results that can be used to have best multi-objective in respective concerns

UV-Spectrophotometry - Multicomponent Mode of Analysis for Simultaneous Estimation of Brinzolamide and Brimonidine Tartrate in Bulk and Ophthalmic Formulation

Brinzolamide (BRZ) and Brimonidine Tartrate (BT) in combination are available as an ophthalmic suspension in the ratio of 5:1. A simple, reproducible and efficient method for the simultaneous determination of BRZ and BT in Bulk and Ophthalmic formulation has been developed. The absorbance was assessed at two wavelengths i.e. 252.40 nm (λ max of BRZ) and 246 nm (λmax of BT) in methanol. In this method, BRZ and BT executed linearity in the concentration range of 5-35 μg/mL and 3-18 μg/mL, respectively at their respective λ max. The developed method was found to be accurate, precise and rugged as marked by small values of % RSD according to ICH guidelines

An efficient one-pot multicomponent, Amberlite IR120(H) catalyzed microwave-assisted synthesis of 1,2,4,5-tetrasubstituted-1<i>H</i>-imidazoles: Plausible mechanism and antibacterial evaluation

The present study describes an efficient and convenient one-pot multicomponent, microwave-assisted synthesis of polysubstituted-1H-imidazoles in good yields under mild reaction conditions. The procedure uses inexpensive, nontoxic, and reusable Amberlite IR120(H) as a catalyst. The new method exhibits a broad tolerance for diverse structural moieties, thereby demonstrating the robustness and applicability of the synthetic method. Further synthesized polysubstituted-1H-imidazoles exhibited moderate to good activity against bacterial strains under study.</p