An XMM and Chandra view of massive clusters of galaxies to z=1

The X-ray properties of a sample of high redshift (z>0.6), massive clusters observed with XMM-Newton and Chandra are described, including two exceptional systems. One, at z=0.89, has an X-ray temperature of T=11.5 (+1.1, -0.9) keV (the highest temperature of any cluster known at z>0.6), an estimated mass of (1.4+/-0.2)x10^15 solar masses and appears relaxed. The other, at z=0.83, has at least three sub-clumps, probably in the process of merging, and may also show signs of faint filamentary structure at large radii,observed in X-rays. In general there is a mix of X-ray morphologies, from those clusters which appear relaxed and containing little substructure to some highly non-virialized and probably merging systems. The X-ray gas metallicities and gas mass fractions of the relaxed systems are similar to those of low redshift clusters of the same temperature, suggesting that the gas was in place, and containing its metals, by z=0.8. The evolution of the mass-temperature relation may be consistent with no evolution or with the ``late formation'' assumption. The effect of point source contamination in the ROSAT survey from which these clusters were selected is estimated, and the implications for the ROSAT X-ray luminosity function discussed.Comment: 9 pages, in Carnegie Observatories Astrophysics Series, Vol. 3: Clusters of Galaxies: Probes of Cosmological Structure and Galaxy Evolution, ed. J. S. Mulchaey, A. Dressler, and A. Oemler. See http://www.ociw.edu/ociw/symposia/series/symposium3/proceedings.html for a full-resolution versio

Anomalous microwave emission from spinning nanodiamonds around stars

Several interstellar environments produce 'anomalous microwave emission' (AME), with brightness peaks at tens-of-gigahertz frequencies. The emission's origins are uncertain -- rapidly spinning nanoparticles could emit electric-dipole radiation, but the polycyclic aromatic hydrocarbons that have been proposed as the carrier are now found not to correlate with Galactic AME signals. The difficulty is in identifying co-spatial sources over long lines of sight. Here we identify AME in three proto-planetary discs. These are the only known systems that host hydrogenated nanodiamonds, in contrast to the very common detection of polycyclic aromatic hydrocarbons. Using spectroscopy, the nanodiamonds are located close to the host stars, at physically well-constrained temperatures. Developing disc models, we reproduce the emission with diamonds 0.75--1.1 nm in radius, holding <= 1-2% of the carbon budget. Ratios of microwave emission to stellar luminosity are approximately constant, allowing nanodiamonds to be ubiquitous but emitting below detection thresholds in many star systems. This result is compatible with the findings with similar-sized diamonds found within Solar System meteorites. As nanodiamond spectral absorption is seen in interstellar sightlines, these particles are also a candidate for generating galaxy-scale AME

Damage function for historic paper. Part I: Fitness for use

Background In heritage science literature and in preventive conservation practice, damage functions are used to model material behaviour and specifically damage (unacceptable change), as a result of the presence of a stressor over time. For such functions to be of use in the context of collection management, it is important to define a range of parameters, such as who the stakeholders are (e.g. the public, curators, researchers), the mode of use (e.g. display, storage, manual handling), the long-term planning horizon (i.e. when in the future it is deemed acceptable for an item to become damaged or unfit for use), and what the threshold of damage is, i.e. extent of physical change assessed as damage. Results In this paper, we explore the threshold of fitness for use for archival and library paper documents used for display or reading in the context of access in reading rooms by the general public. Change is considered in the context of discolouration and mechanical deterioration such as tears and missing pieces: forms of physical deterioration that accumulate with time in libraries and archives. We also explore whether the threshold fitness for use is defined differently for objects perceived to be of different value, and for different modes of use. The data were collected in a series of fitness-for-use workshops carried out with readers/visitors in heritage institutions using principles of Design of Experiments. Conclusions The results show that when no particular value is pre-assigned to an archival or library document, missing pieces influenced readers/visitors’ subjective judgements of fitness-for-use to a greater extent than did discolouration and tears (which had little or no influence). This finding was most apparent in the display context in comparison to the reading room context. The finding also best applied when readers/visitors were not given a value scenario (in comparison to when they were asked to think about the document having personal or historic value). It can be estimated that, in general, items become unfit when text is evidently missing. However, if the visitor/reader is prompted to think of a document in terms of its historic value, then change in a document has little impact on fitness for use

An assessment of road-verge grass as a feedstock for farm-fed anaerobic digestion plants

Cuttings from road-verge grass could provide biomass for energy generation, but currently this potential is not exploited. This research assessed the technical, practical and financial feasibility of using grass harvested from road verges as a feedstock in farm-fed anaerobic digestion (AD) plants. The methane potential (191 mL CH4 gDM−1) and digestion characteristics of verge grass were similar to those of current farm feedstocks; indicating suitability for AD. Ensiling had no significant impact on the biomethane generated. Testing co-digestions of verge grass with current farm feedstocks showed enhanced methane yields, suggesting that verge grass could be a valuable addition to AD feedstock mixes. In a case study of the UK county of Lincolnshire, potential volumes and locations of verge grass biomass were estimated, with capacities and locations of existing AD plants, to assess the potential to supply practical grass volumes. Grass harvesting costs were modelled and compared with other feedstock costs. Finally, the attitudes of AD operators to using verge grass were investigated to understand whether a market for verge grass exists. In a small survey all operators were willing to use it as a feedstock and most were prepared to pay over the estimated harvesting cost. If verge grass was legally recognised as a waste product it could be attractive to AD operators especially where financial incentives to use waste feedstocks are in place. In rural areas, verge grass could be harvested and co-digested by existing farm-fed AD plants, potentially reducing the cost of road verge maintenance and increasing biodiversity

Are lay people good at recognising the symptoms of schizophrenia?

©2013 Erritty, Wydell. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.This article has been made available through the Brunel Open Access Publishing Fund.Aim: The aim of this study was to explore the general public’s perception of schizophrenia symptoms and the need to seekhelp for symptoms. The recognition (or ‘labelling’) of schizophrenia symptoms, help-seeking behaviours and public awareness of schizophrenia have been suggested as potentially important factors relating to untreated psychosis. Method: Participants were asked to rate to what extent they believe vignettes describing classic symptoms (positive and negative) of schizophrenia indicate mental illness. They were also asked if the individuals depicted in the vignettes required help or treatment and asked to suggest what kind of help or treatment. Results: Only three positive symptoms (i.e., Hallucinatory behaviour, Unusual thought content and Suspiciousness) of schizophrenia were reasonably well perceived (above 70%) as indicating mental illness more than the other positive or negative symptoms. Even when the participants recognised that the symptoms indicated mental illness, not everyone recommended professional help. Conclusion: There may be a need to improve public awareness of schizophrenia and psychosis symptoms, particularly regarding an awareness of the importance of early intervention for psychosis

Qualitative evaluation of media device orchestration for immersive spatial audio reproduction

The challenge of installing and setting up dedicated spatial audio systems can make it difficult to deliver immersive listening experiences to the general public. However, the proliferation of smart mobile devices and the rise of the Internet of Things mean that there are increasing numbers of connected devices capable of producing audio in the home. \Media device orchestration" (MDO) is the concept of utilizing an ad hoc set of devices to deliver or augment a media experience. In this paper, the concept is evaluated by implementing MDO for augmented spatial audio reproduction using object-based audio with semantic metadata. A thematic analysis of positive and negative listener comments about the system revealed three main categories of response: perceptual, technical, and content-dependent aspects. MDO performed particularly well in terms of immersion/envelopment, but the quality of listening experience was partly dependent on loudspeaker quality and listener position. Suggestions for further development based on these categories are given

Understanding ligand binding selectivity in a prototypical GPCR family

Adenosine receptors are involved in many pathological conditions and are thus promising drug targets. However, developing drugs that target this GPCR subfamily is a challenging task. A number of drug candidates fail due to lack of selectivity which results in unwanted side effects. The extensive structural similarity of adenosine receptors complicates the design of selective ligands. The problem of selective targeting is a general concern in GPCRs and in this respect adenosine receptors are a prototypical example. Here we use enhanced sampling simulations to decipher the determinants of selectivity of ligands in A2a and A1 adenosine receptors. Our model shows how small differences in the binding pocket and in the water network around the ligand can be leveraged to achieve selectivity

New 10Be exposure ages improve Holocene ice sheet thinning history near the grounding line of Pope Glacier, Antarctica

Evidence for the timing and pace of past grounding line retreat of the Thwaites Glacier system in the Amundsen Sea embayment (ASE) of Antarctica provides constraints for models that are used to predict the future trajectory of the West Antarctic Ice Sheet (WAIS). Existing cosmogenic nuclide surface exposure ages suggest that Pope Glacier, a former tributary of Thwaites Glacier, experienced rapid thinning in the early to mid-Holocene. There are relatively few exposure ages from the lower ice-free sections of Mount Murphy (< 300 m asl) that are uncomplicated by either nuclide inheritance or scattering due to localised topographic complexities; this makes the trajectory for the latter stages of deglaciation uncertain. This paper presents 12 new 10Be exposure ages from erratic cobbles collected from the western flank of Mt Murphy, within 160 m of the modern ice surface and 1 km from the present grounding line. The ages comprise two tightly clustered populations with mean deglaciation ages of 7.1 ± 0.1 ka and 6.4 ± 0.1 ka (1SE). Linear regression analysis applied to the age-elevation array of all available exposure ages from Mt Murphy indicates that the median rate of thinning of Pope Glacier was 0.27 m yr-1 between 8.1–6.3 ka, occurring 1.5 times faster than previously thought. Furthermore, this analysis better constrains the uncertainty (95 % confidence interval) in the timing of deglaciation at the base of the Mt Murphy vertical profile (~80 m above the modern ice surface), shifting it to earlier in the Holocene (from 5.2 ± 0.7 ka to 6.3 ± 0.4 ka). Taken together, the results presented here suggest that early–mid Holocene thinning of Pope Glacier occurred over a shorter interval than previously assumed and permit a longer duration over which subsequent late Holocene rethickening could have occurred

Cooperation and Contagion in Web-Based, Networked Public Goods Experiments

A longstanding idea in the literature on human cooperation is that cooperation should be reinforced when conditional cooperators are more likely to interact. In the context of social networks, this idea implies that cooperation should fare better in highly clustered networks such as cliques than in networks with low clustering such as random networks. To test this hypothesis, we conducted a series of web-based experiments, in which 24 individuals played a local public goods game arranged on one of five network topologies that varied between disconnected cliques and a random regular graph. In contrast with previous theoretical work, we found that network topology had no significant effect on average contributions. This result implies either that individuals are not conditional cooperators, or else that cooperation does not benefit from positive reinforcement between connected neighbors. We then tested both of these possibilities in two subsequent series of experiments in which artificial seed players were introduced, making either full or zero contributions. First, we found that although players did generally behave like conditional cooperators, they were as likely to decrease their contributions in response to low contributing neighbors as they were to increase their contributions in response to high contributing neighbors. Second, we found that positive effects of cooperation were contagious only to direct neighbors in the network. In total we report on 113 human subjects experiments, highlighting the speed, flexibility, and cost-effectiveness of web-based experiments over those conducted in physical labs

Prescribing practices of primary-care veterinary practitioners in dogs diagnosed with bacterial pyoderma

Concern has been raised regarding the potential contributions of veterinary antimicrobial use to increasing levels of resistance in bacteria critically important to human health. Canine pyoderma is a frequent, often recurrent diagnosis in pet dogs, usually attributable to secondary bacterial infection of the skin. Lesions can range in severity based on the location, total area and depth of tissue affected and antimicrobial therapy is recommended for resolution. This study aimed to describe patient signalment, disease characteristics and treatment prescribed in a large number of UK, primary-care canine pyoderma cases and to estimate pyoderma prevalence in the UK vet-visiting canine population