Ultrasonic spectrometry and modelling that verifies shear-wave reconversion in micro- and nano-fluids

Ultrasonic spectrometry and modelling that verifies shear-wave reconversion in micro- and nano-fluid

Bulk and surface rheology of Aculyn™ 22 and Aculyn™ 33 polymeric solutions and kinetics of foam drainage

Experimental investigations of both bulk and surface rheology of solutions of commercially available polymers AculynTM 22 and AculynTM 33 in presence of sodium chloride are performed in a wide range of the polymer and salt concentrations. It is shown that the bulk viscosity and the surface viscoelastic modulus of solutions of both polymers increases with the increase of polymer concentration and the decrease of the salt concentration. Solutions of both polymers demonstrate very good foamability and form stable foams. Foam drainage is governed mainly by the bulk viscosity when the latter is in the range of 100-500 mPa·s

Multistep simulation for three-dimensional ice accretion on an aircraft wing

A simplified icing model combined with Eulerian two-phase flow theory has been proposed and the method was employed for direct simulation of ice accretion occurred on an aircraft wing. An innovative wall boundary condition treatment has been proposed to properly depict the phenonmenon of droplet impact on the wing surface, resulting in enhanced numerical stability in solution process and better agreement with experimental data. The icing model was derived on the basis of the extended Messinger model, and as well as the assumption that the overflow direction follows the air streamline just above the water film. Several concepts like the critical ice thickness have been presented to facilitate the use of this icing model for predicting three-dimensional ice accretions. Preliminary multistep simulation results for one moderate mixed ice accretion case are compared with available experimental data, together with the corresponding single-step results. Further simulation case studies concerning typical glaze ice of more irregular shape and the effect of simulation step interval to update the geometry and the flowfield will be conduted and detailed results will be presented in the final manuscript</p

Porous Polymeric Films from Microbubbles Generated Using a T‑Junction Microfluidic Device

In this work, a simple microfluidic junction with a T geometry and coarse (200 μm diameter) capillaries was used to generate monodisperse microbubbles with an alginate polymer shell. Subsequently, these bubbles were used to prepare porous alginate films with good control over the pore structure. The lack of pore size, shape, and surface control in scalable forming of polymeric films is a major application-limiting drawback at present. Controlling the thinning process of the shell of the bubbles to tune the surface of the resulting structures was also explored. Films were prepared with nanopatterned surfaces by controlling the thinning of the bubble shell, with the aid of surfactants, to induce efficient bursting (fragmentation) of bubbles to generate nanodroplets, which become embedded within the film surface. This novel feature greatly expands and enhances the use of hydrophilic polymers in a wide range of biomedical applications, particularly in drug delivery and tissue engineering, such as studying cellular responses to different morphological surfaces

Porous Polymeric Films from Microbubbles Generated Using a T‑Junction Microfluidic Device

In this work, a simple microfluidic junction with a T geometry and coarse (200 μm diameter) capillaries was used to generate monodisperse microbubbles with an alginate polymer shell. Subsequently, these bubbles were used to prepare porous alginate films with good control over the pore structure. The lack of pore size, shape, and surface control in scalable forming of polymeric films is a major application-limiting drawback at present. Controlling the thinning process of the shell of the bubbles to tune the surface of the resulting structures was also explored. Films were prepared with nanopatterned surfaces by controlling the thinning of the bubble shell, with the aid of surfactants, to induce efficient bursting (fragmentation) of bubbles to generate nanodroplets, which become embedded within the film surface. This novel feature greatly expands and enhances the use of hydrophilic polymers in a wide range of biomedical applications, particularly in drug delivery and tissue engineering, such as studying cellular responses to different morphological surfaces

Porous Polymeric Films from Microbubbles Generated Using a T‑Junction Microfluidic Device

In this work, a simple microfluidic junction with a T geometry and coarse (200 μm diameter) capillaries was used to generate monodisperse microbubbles with an alginate polymer shell. Subsequently, these bubbles were used to prepare porous alginate films with good control over the pore structure. The lack of pore size, shape, and surface control in scalable forming of polymeric films is a major application-limiting drawback at present. Controlling the thinning process of the shell of the bubbles to tune the surface of the resulting structures was also explored. Films were prepared with nanopatterned surfaces by controlling the thinning of the bubble shell, with the aid of surfactants, to induce efficient bursting (fragmentation) of bubbles to generate nanodroplets, which become embedded within the film surface. This novel feature greatly expands and enhances the use of hydrophilic polymers in a wide range of biomedical applications, particularly in drug delivery and tissue engineering, such as studying cellular responses to different morphological surfaces

The UK10K project identifies rare variants in health and disease

The contribution of rare and low-frequency variants to human traits is largely unexplored. Here we describe insights from sequencing whole genomes (low read depth, 7×) or exomes (high read depth, 80×) of nearly 10,000 individuals from population-based and disease collections. In extensively phenotyped cohorts we characterize over 24 million novel sequence variants, generate a highly accurate imputation reference panel and identify novel alleles associated with levels of triglycerides (APOB), adiponectin (ADIPOQ) and low-density lipoprotein cholesterol (LDLR and RGAG1) from single-marker and rare variant aggregation tests. We describe population structure and functional annotation of rare and low-frequency variants, use the data to estimate the benefits of sequencing for association studies, and summarize lessons from disease-specific collections. Finally, we make available an extensive resource, including individual-level genetic and phenotypic data and web-based tools to facilitate the exploration of association results

The IASLC Lung Cancer Staging Project: A Renewed Call to Participation

Over the past two decades, the International Association for the Study of Lung Cancer (IASLC) Staging Project has been a steady source of evidence-based recommendations for the TNM classification for lung cancer published by the Union for International Cancer Control and the American Joint Committee on Cancer. The Staging and Prognostic Factors Committee of the IASLC is now issuing a call for participation in the next phase of the project, which is designed to inform the ninth edition of the TNM classification for lung cancer. Following the case recruitment model for the eighth edition database, volunteer site participants are asked to submit data on patients whose lung cancer was diagnosed between January 1, 2011, and December 31, 2019, to the project by means of a secure, electronic data capture system provided by Cancer Research And Biostatistics in Seattle, Washington. Alternatively, participants may transfer existing data sets. The continued success of the IASLC Staging Project in achieving its objectives will depend on the extent of international participation, the degree to which cases are entered directly into the electronic data capture system, and how closely externally submitted cases conform to the data elements for the project

The Herschel Multi-Tiered Extragalactic Survey: source extraction and cross-identifications in confusion-dominated SPIRE images

We present the cross-identification and source photometry techniques used to process Herschel SPIRE imaging taken as part of the Herschel Multi-Tiered Extragalactic Survey (HerMES). Cross-identifications are performed in map-space so as to minimize source-blending effects. We make use of a combination of linear inversion and model selection techniques to produce reliable cross-identification catalogues based on Spitzer MIPS 24-μm source positions. Testing on simulations and real Herschel observations shows that this approach gives robust results for even the faintest sources (S250∼ 10 mJy). We apply our new technique to HerMES SPIRE observations taken as part of the science demonstration phase of Herschel. For our real SPIRE observations, we show that, for bright unconfused sources, our flux density estimates are in good agreement with those produced via more traditional point source detection methods (SUSSEXtractor) by Smith et al. When compared to the measured number density of sources in the SPIRE bands, we show that our method allows the recovery of a larger fraction of faint sources than these traditional methods. However, this completeness is heavily dependent on the relative depth of the existing 24-μm catalogues and SPIRE imaging. Using our deepest multiwavelength data set in the GOODS-N, we estimate that the use of shallow 24-μm catalogues in our other fields introduces an incompleteness at faint levels of between 20–40 per cent at 250 μm

Cold dust and young starbursts: spectral energy distributions of Herschel SPIRE sources from the HerMES survey

We present spectral energy distributions (SEDs) for 68 Herschel sources detected at 5σ at 250, 350 and 500 μm in the HerMES SWIRE-Lockman field. We explore whether existing models for starbursts, quiescent star-forming galaxies and active galactic nucleus dust tori are able to model the full range of SEDs measured with Herschel. We find that while many galaxies (∼56 per cent) are well fitted with the templates used to fit IRAS, Infrared Space Observatory (ISO) and Spitzer sources, for about half the galaxies two new templates are required: quiescent (‘cirrus’) models with colder (10–20 K) dust and a young starburst model with higher optical depth than Arp 220. Predictions of submillimetre fluxes based on model fits to 4.5–24 μm data agree rather poorly with the observed fluxes, but the agreement is better for fits to 4.5–70 μm data. Herschel galaxies detected at 500 μm tend to be those with the highest dust masses