Beta lives - some statistical perspectives on the capital asset pricing model

This note summarizes some technical issues relevant to the use of the idea of excess return in empirical modelling. We cover the case where the aim is to construct a measure of expected return on an asset and a model of the CAPM type is used. We review some of the problems and show examples where the basic CAPM may be used to develop other results which relate the expected returns on assets both to the expected return on the market and other factors

Intracellular Penetration and Accumulation of Radiographic Contrast Media in the Rat Kidney

Radiographic iodine-containing contrast media (meglumine calcium metrizoate, iohexol and meglumine sodium ioxaglate) were injected intravenously in rats. At various intervals after exposure, in situ cryofixation of kidneys was performed. Thin, freeze-dried cryosections were examined by electron microscopy and X-ray microanalysis. In endothelial cells, erythrocytes and tubular cells high dry weight concentrations of iodine were found. Twenty-four hours after iohexol was injected, no trace of iodine was found in the plasma, microvilli or the nuclei of the tubular cells. Small organelle-like compartments in the cytoplasm of the proximal tubular cells contained high concentrations of iodine, whereas no iodine was found in the surrounding cytoplasm. Since no metabolism of contrast medium has been demonstrated, the iodine signals must be emitted from contrast medium molecules. Other elements were also measured, with the concentrations being always within the ranges found in tubular cells of control animals. The detection of intracellular contrast thus does not seem to be an artifact due to cell injury, but rather represents a physiological event in healthy cells in the rat kidney. Our results are in contradiction to the prevailing opinion that contrast media do not enter healthy cells. However, previous conclusions have been based on the use of conventional preparation methods, and the highly water soluble contrast molecules may have been lost during the different steps of fixation and processing

Focused Crossed Andreev Reflection

We consider non-local transport in a system with one superconducting and two normal metal terminals. Electron focusing by weak perpendicular magnetic fields is shown to tune the ratio between crossed Andreev reflection (CAR) and electron transfer (ET) in the non-local current response. Additionally, electron focusing facilitates non-local signals between normal metal contacts where the separation is as large as the mean free path rather than being limited by the coherence length of the superconductor. CAR and ET can be selectively enhanced by modulating the magnetic field

Simvastatin coating of TiO2 scaffold induces osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells

AbstractBone tissue engineering requires an osteoconductive scaffold, multipotent cells with regenerative capacity and bioactive molecules. In this study we investigated the osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells (hAD-MSCs) on titanium dioxide (TiO2) scaffold coated with alginate hydrogel containing various concentrations of simvastatin (SIM). The mRNA expression of osteoblast-related genes such as collagen type I alpha 1 (COL1A1), alkaline phosphatase (ALPL), osteopontin (SPP1), osteocalcin (BGLAP) and vascular endothelial growth factor A (VEGFA) was enhanced in hAD-MSCs cultured on scaffolds with SIM in comparison to scaffolds without SIM. Furthermore, the secretion of osteoprotegerin (OPG), vascular endothelial growth factor A (VEGFA), osteopontin (OPN) and osteocalcin (OC) to the cell culture medium was higher from hAD-MSCs cultured on scaffolds with SIM compared to scaffolds without SIM. The TiO2 scaffold coated with alginate hydrogel containing SIM promote osteogenic differentiation of hAD-MSCs in vitro, and demonstrate feasibility as scaffold for hAD-MSC based bone tissue engineering

The spirit of sport: the case for criminalisation of doping in the UK

This article examines public perceptions of doping in sport, critically evaluates the effectiveness of current anti-doping sanctions and proposes the criminalisation of doping in sport in the UK as part of a growing global movement towards such criminalisation at national level. Criminalising doping is advanced on two main grounds: as a stigmatic deterrent and as a form of retributive punishment enforced through the criminal justice system. The ‘spirit of sport’ defined by the World Anti-Doping Agency (WADA) as being based on the values of ethics, health and fair-play is identified as being undermined by the ineffectiveness of existing anti-doping policy in the current climate of doping revelations, and is assessed as relevant to public perceptions and the future of sport as a whole. The harm-reductionist approach permitting the use of certain performance enhancing drugs (PEDs) is considered as an alternative to anti-doping, taking into account athlete psychology, the problems encountered in containing doping in sport through anti-doping measures and the effect of these difficulties on the ‘spirit of sport’. This approach is dismissed in favour of criminalising doping in sport based on the offence of fraud. It will be argued that the criminalisation of doping could act as a greater deterrent than existing sanctions imposed by International Federations, and, when used in conjunction with those sanctions, will raise the overall ‘price’ of doping. The revelations of corruption within the existing system of self-governance within sport have contributed to a disbelieving public and it will be argued that the criminalisation of doping in sport could assist in satisfying the public that justice is being done and in turn achieve greater belief in the truth of athletic performances

Two-stage dissipation in a superconducting microbridge: Experiment and modeling

Using fluorescent microthermal imaging we have investigated the origin of "two-step" behavior in I-V curves for a current-carrying YBa_2Cu_3O_x superconducting bridge. High resolution temperature maps reveal that as the applied current increases the first step in the voltage corresponds to local dissipation (hot spot), whereas the second step is associated with onset of global dissipation throughout the entire bridge. A quantitative explanation of the experimental results is provided by a simple model for an inhomogeneous superconductor, assuming that the hot spot nucleates at a location with slightly depressed superconducting properties.Comment: 4 pages, 4 figure

The onset of a small-scale turbulent dynamo at low magnetic Prandtl numbers

We study numerically the dependence of the critical magnetic Reynolds number Rmc for the turbulent small-scale dynamo on the hydrodynamic Reynolds number Re. The turbulence is statistically homogeneous, isotropic, and mirror--symmetric. We are interested in the regime of low magnetic Prandtl number Pm=Rm/Re<1, which is relevant for stellar convective zones, protostellar disks, and laboratory liquid-metal experiments. The two asymptotic possibilities are Rmc->const as Re->infinity (a small-scale dynamo exists at low Pm) or Rmc/Re=Pmc->const as Re->infinity (no small-scale dynamo exists at low Pm). Results obtained in two independent sets of simulations of MHD turbulence using grid and spectral codes are brought together and found to be in quantitative agreement. We find that at currently accessible resolutions, Rmc grows with Re with no sign of approaching a constant limit. We reach the maximum values of Rmc~500 for Re~3000. By comparing simulations with Laplacian viscosity, fourth-, sixth-, and eighth-order hyperviscosity and Smagorinsky large-eddy viscosity, we find that Rmc is not sensitive to the particular form of the viscous cutoff. This work represents a significant extension of the studies previously published by Schekochihin et al. 2004, PRL 92, 054502 and Haugen et al. 2004, PRE, 70, 016308 and the first detailed scan of the numerically accessible part of the stability curve Rmc(Re).Comment: 4 pages, emulateapj aastex, 2 figures; final version as published in ApJL (but with colour figures

Beginning Counselor Educators’ Experiences of Teaching Mentorship

Mentoring can positively impact counselor educators’ teaching in terms of self-efficacy and growth in skills. Yet, counselor educators have reported a desire for more mentoring in the development of their teaching. Utilizing consensual qualitative research methodology, we explored the teaching-specific mentorship of beginning counselor educators’ (N = 13) within their first two to four years as faculty. Emergent themes included mentoring structure such as mentors’ methods of providing mentorship, mentoring relationship dynamics such as relational supports and frustrations, and the positive and negative impacts of mentoring relationships. In addition to building rapport and strengthening mentees’ self-efficacy, mentors and mentees can develop intentional mentoring relationships with a comprehensive focus emphasizing the development of teaching knowledge and skills through practices such as teaching observation and feedback. Additionally, discussing the needs, goals, and expectations of both parties and the inherent power differential of the relationships can help focus the mentoring experiences

HPV prevalence and concordance in the cervix and oral cavity of pregnant women.

OBJECTIVES: This investigation examined human papillomavirus (HPV) in pregnant women in order to characterize viral prevalence, types and concordance between infection in the cervix and in the oral cavity. METHODS: A total of 577 pregnant women seeking routine obstetric care were evaluated for HPV infection in their cervix during gestation and immediately before delivery, and in the oral cavity during gestation. Male partners present during the gestational clinic visit also provided a specimen from their oral cavity. HPV assessment was performed by PCR, dot blot hybridization and DNA sequencing. A sexual and health questionnaire was completed by the pregnant women. RESULTS: HPV prevalence in women was 29% in the cervix and 2.4% in the oral cavity. Among those with both gestational and delivery specimens, 35% were infected at least once and 20% had infection at both intervals. At delivery, 68% of infected women had an oncogenic HPV type in the cervix. There was no type-specific HPV concordance between the two cervical specimens, nor cervical and oral results in women, nor with cervical and oral findings between partners. CONCLUSION: The lack of association in HPV positivity and types between the cervix and oral cavity in these women suggests that self-inoculation is uncommon. This source of infection does not appear to be from oral contact with a current male partner, since there also was no concordance between partners. These results suggest either other modes of HPV transmission or differences in susceptibility to HPV infection or its clearance in the oral cavity and genital mucosa