145 research outputs found
Insights into the Mechanism of Myosin V Processivity from Point Mutations in the Converter Domain
2C-R4WM spectroscopy of jet cooled NO3
We have generated NO from pyrolysis of NO following supersonic free jet expansion, and carried out two color resonant four wave mixing (~2C-R4WM~) spectroscopy of the -- electronic transition.
One laser was fixed to pump NO to a ro-vibronic level of the state, and the other laser (~probe~) was scanned across two levels of the state lying at 1051 and 1492 cm, the () and () fundamentals, respectively.
The 2C-R4WM spectra have unexpected back-ground signal of NO (~stray signal due to experimental set-up is also detected~) similar to laser induced fluorescence (~LIF~) excitation spectrum of the 0-0 band, although the back-ground signal was not expected in considering the 2C-R4WM scheme.
Despite the back-ground interference, we have observed two peaks at 1051.61 and 1055.29 cm in the region of the spectrum, and the frequencies agree with the two bands, 1051.2 and 1055.3 cm, of our relatively higher resolution dispersed fluorescence spectrum, the former of which has been assigned to the fundamental.
Band width of both peaks, 0.2 cm, is broader than twice the experimental spectral-resolution, 0.04 cm (~because this experiment is double resonance spectroscopy~), and the 1051.61 cm peak is attributed to a branch band head (~a line-like branch~) of the fundamental.
The other branches are suspected to be hidden in noise of the back-ground signal.
The 1055.29 cm peak is also attributed to a band head.
The (~, ~) -- (~, ~) ro-vibronic transition was used as the pump transition.
The dump (~probe~) transition to both and vibronic levels are then allowed as perpendicular transition.
Accordingly, it cannot be determined from present results whether the 1055.29 cm band is attributed to or (), unfortunately.
The 2C-R4WM spectrum of the 1492 cm band region shows one head at 1499.79 cm, which is consistent with our dispersed fluorescence spectrum.
By considering with the + - hot band\footnote{K.~Kawaguchi , 117, 13732 (2013) and E.~Hirota, 310, 99 (2015).}, the present results suggest that both 1055.29 and 1499.79 cm levels are level
Molecular phylogenetic analyses support the monophyly of Hexapoda and suggest the paraphyly of Entognatha
Oral administration of γ-aminobutyric acid affects heat production in a hot environment in resting humans
Radiosynthesis and in vivo evaluation of two imidazopyridineacetamides, [11C]CB184 and [11C]CB190, as a PET tracer for 18Â kDa translocator protein: direct comparison with [11C](R)-PK11195
Objective: We report synthesis of two carbon-11 labeled imidazopyridines TSPO ligands, [11C]CB184 and [11C]CB190, for PET imaging of inflammatory process along with neurodegeneration, ischemia or brain tumor. Biodistribution of these compounds was compared with that of [11C]CB148 and [11C](R)-PK11195. Methods: Both [11C]CB184 and [11C]CB190 having 11C-methoxyl group on an aromatic ring were readily prepared using [11C]methyl triflate. Biodistribution and metabolism of the compounds were examined with normal mice. An animal PET study using 6-hydroxydopamine treated rats as a model of neurodegeneration was pursued for proper estimation of feasibility of the radioligands to determine neuroinflammation process. Results: [11C]CB184 and [11C]CB190 were obtained via O-methylation of corresponding desmethyl precursor using [11C]methyl triflate in radiochemical yield of 73 % (decay-corrected). In vivo validation as a TSPO radioligand was carried out using normal mice and lesioned rats. In mice, [11C]CB184 showed more uptake and specific binding than [11C]CB190. Metabolism studies showed that 36 % and 25 % of radioactivity in plasma remained unchanged 30 min after intravenous injection of [11C]CB184 and [11C]CB190, respectively. In the PET study using rats, lesioned side of the brain showed significantly higher uptake than contralateral side after i.v. injection of either [11C]CB184 or [11C](R)-PK11195. Indirect Logan plot analysis revealed distribution volume ratio (DVR) between the two sides which might indicate lesion-related elevation of TSPO binding. The DVR was 1.15 ± 0.10 for [11C](R)-PK11195 and was 1.15 ± 0.09 for [11C]CB184. Conclusion: The sensitivity to detect neuroinflammation activity was similar for [11C]CB184 and [11C](R)-PK11195
Monoester Formation by Hydrolysis of Dialkyl Phthalate Migrating from Polyvinyl Chloride Products in Human Saliva.
Establishment and characterization of a cell line (HCH-1) originating from a human clear cell carcinoma of the ovary
THE C-N STRETCHING VIBRONIC BANDS OF THE MgNC TRANSITION
R. R. Wright and T. A. Miller, J. Mol. Spectrosc. 194, 219 (1999).Author Institution: Faculty of Information Sciences, Hiroshima City UniversityWe have generated MgNC in supersonic free jet expansions, and measured the laser induced fluorescence excitation spectra of the C-N stretching vibronic bands of the transition. Rotational analysis yields the molecular constants of the vibronic levels, (1,0,0) and (1,0,1), in the state. The vibronic levels, (0,0,0), (0,1,0), and (0,0,1), were already analyzed by . We can not find any anomalies in the constants of the C-N stretching vibronic levels, while they are predicted to be lying above the barrier of the isomerization reaction pathway, MgNC MgCN, on the state. On the basis of the molecular constants obtained, we discuss the fine structures of both the ground and excited states
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