750 Natalia the economic and legal analysis of the terms of international delivery contracts involving Russian suppliers

Purpose: The article presents an economic and legal analysis of the terms of contracts for international delivery of goods involving Russian suppliers. Design/Methodology/Approach: The authors analysed the international norms of regulating relations for the goods’ delivery involving the foreign element. Terms of the goods delivery are investigated according to the national legislation of the Russian Federation. Findings: As a result, it is necessary to use an economic and legal approach when developing contract terms for the goods’ delivery to take into account norms of international law, the national legislation of the supplier country and in accordance with the calculations of the contract price and payment terms. Practical Implications: The proposed method is in accordance with the international legal framework and it can be adopted by the Russian Federation easily. Originality/Value: There is no such an approach eligible to modernize the existing system in the country.peer-reviewe

Impact of technological blockchain paradigm on the movement of intellectual property in the digital space

The article is dedicated to investigate the problem of influence of cutting edge digital technology on the virtual and real legal relations, related to the movement and the turnover of intellectual property. Using the method of analyzing modern definitions of blockchain, and relying on the political-economic theory of social redistribution of wealth, authors define the term blockchain and its principles as a technological paradigm. Authors conclude the fact that blockchain can be used to guarantee intellectual property rights and it should be accepted at the national level. As a mechanism of a trusted environment, blockchain allows to reduce transaction costs and increase the level of commercialization of intellectual property.peer-reviewe

Avoiding errors in the diagnosis of polypoidal choroidal vasculopathy in patients with age-related macular degeneration (Part 1)

Background: Poor availability of indocyanine green angiography (ICGA) raises the question of how to improve the diagnosis of polypoidal choroidal vasculopathy (PCV) using alternative imaging modalities, optical coherence tomography (OCT) and OCR angiography (OCTA). Purpose: To optimize the diagnosis of PCV in patients with age-related macular degeneration (AMD) using non-invasive methods, OCT and OCTA. Material and Methods: One hundred and sixty-nine patients (228 eyes) with neovascular AMD underwent OCT and OCTA study as per the proposed algorithm to differentiate between PCV and other types of subretinal neovascularization. Of these, 14 patients (8.28%; 14 eyes) were found to have PCV. Results: Major and additional signs of PCV, secondary neovascularization and activity of the process on OCT were determined. In addition, we determined the signs of PCV on OCTA manu-al and automatic segmentation which will be helpful in accurate differential diagnosis of the disease. On the basis of these data, we developed a step-by-step algorithm of the OCT and OC-TA diagnosis of PCV in patients suspected of the disease, which allows the accurate diagnosis when ICGA is unavailable. Conclusion: Systematic step-by-step interpretation of OCT and OCTA scans allow the reliable differential diagnosis of PCV in patients with exudative AMD

Analysis of human resources management in the control system of GAUZ SO "СGKB № 3"

The article analyzes human resource management in GAUZ SO "TsGKB № 3" by means of determining the motivational mechanism of the staff of the antenatal clinic, as well as insufficient incentives for workers. The relevance of the chosen topic lies in the fact that the lack of medical personnel is one of the most important problems of the system. The provision of the health care system with qualified medical personnel is an important condition that determines the availability and quality of medical care for the population.В статье проведен анализ управления человеческими ресурсами в ГАУЗ СО «ЦГКБ №3» по средствам определения мотивационного механизма у сотрудников женской консультации, а также недостаточного стимулирования работников. Актуальность выбранной темы заключается в том, что недостаток медицинских кадров – одна из самых главных проблем системы. Обеспеченность системы здравоохранения квалифицированными медицинскими кадрами является важным условием, определяющим доступность и качество медицинской помощи населению

OCTA-based retinal microvascular bed assessment at the zones ranging from the fovea to the periphery

Background: Studies (particularly, optical coherence tomography angiography (OCTA) studies) on the peripheral microvascular bed in health are important because many retinal disorders involve its injury. Purpose: To improve the efficacy of diagnosing the changes in the retinal microvascular bed through its OCTA-based assessment at the zones ranging from the fovea to the periphery in normal eyes. Material and Methods: Fourteen healthy individuals were included in the study. Three sequential 3 mm x 3 mm OCTA scans with displacement from the center of the fovea to the periphery for each of the three directions (superior, inferior and temporal directions) were registered. Results: Superficial plexus vessel density and deep plexus vessel density were assessed at 1-9 mm from the center of the fovea. We found that superficial plexus vessel density progressively increased (38-46%) with distance from the center of the fovea, whereas deep plexus vessel density moderately decreased (18-25%) with distance from the center. Superficial plexus vessel density was significantly increased in the superior and inferior directions at the zones with the presence of vascular arcades, and these arcades are absent in the temporal direction; this makes the temporal direction most reliable and promising for studies on microcirculation at the ocular periphery. Conclusion: OCTA is an effective technique for assessing the retinal microvascular bed at the zones ranging from the fovea to the far periphery

Experience of radiotechnical college interaction with enterprises within the framework of realization of the fed-eral target program of development of professional education

В статье представлены результаты совместной деятельности в рамках реализации Федеральной целевой программы развития профессионального образования Каменск-Уральского радиотехнического техникума с предприятиями оборонно-промышленного комплекса участвовал в реализации.This article shows the results of Kamensk-Uralsky Radio technical College collaboration with the defenceindustrial sector enterprises in the framework of the implementation of the Federal tar-get program of professional education development

Illusion of victory. measles - «children's infection» with a huge spread

The article describes the chronology of outbreaks of measles in the Russian Federation over the past 18 years, in order to draw attention to the importance of timely prevention of the disease.В статье рассмотрена хронология вспышек заболеваемостью корью в РФ за последние 18 лет, с целью привлечения внимания к важности своевременной профилактики заболевания

Evaluation of the attitude to vaccination of medical university students

The article considers the attitude of medical university students to the need for vaccination, the study of the reasons for refusals, as well as the definition of the most popular and accessible ways to obtain information about vaccination by the population.В статье рассмотрено отношение студентов медицинского университета к необходимости проведения вакцинации, изучению причин отказов, а также определению наиболее популярных и доступных способов получения населением информации о вакцинопрофилактик

Evolution of CpG-islands by means of tandem duplications

CG-rich islands (CpG-islands, or CGI) are important functional elements in a genome of vertebrates. In particular, they: a) initiate transcription as promoters in most (> 50 %) genes of vertebrates, in some cases bi-directional, due to self-complement feature of cg dinucleotides; b) form a global methylation landscape; c) act as a transcription “switch” via methylation. The degenerate nature of CpG-island (elevated CG composition) implies an increase in the probability of tandem repeats and palindromes within CpG- island. This work is devoted to the identification of tandem duplications of complete CpG-islands, i. e. considering mega monomers of size 400–5 000 bp, in the human genome. We found a range of inter- and intragenic tandem duplications of CpG-islands. Intergenic CpGi duplication mediates through CG-rich telomeric satellites, as well as elements of the SINE. One of the most pronounced tandems are located in chromosome 19, known for its abundance of segment duplications and gene expansion. We also underline the unique genomic segment, which is DXZ4 mega satellite, in q arm of chromosome X, also falling into the category of CpG-islands which evolved by tandem duplications rounds