Tritrichomonas foetus Cell Division Involves DNA Endoreplication and Multiple Fissions

Tritrichomonas foetus and Trichomonas vaginalis are extracellular flagellated parasites that inhabit animals and humans, respectively. Cell division is a crucial process in most living organisms that leads to the formation of 2 daughter cells from a single mother cell. It has been assumed that T. vaginalis and T. foetus modes of reproduction are exclusively by binary fission. However, here, we showed that multinuclearity is a phenomenon regularly observed in different T. foetus and T. vaginalis strains in standard culture conditions. Additionally, we revealed that nutritional depletion or nutritional deprivation led to different dormant phenotypes. Although multinucleated T. foetus are mostly observed during nutritional depletion, numerous cells with 1 larger nucleus have been observed under nutritional deprivation conditions. In both cases, when the standard culture media conditions are restored, the cytoplasm of these multinucleated cells separates, and numerous parasites are generated in a short period of time by the fission multiple. We also revealed that DNA endoreplication occurs both in large and multiple nuclei of parasites under nutritional deprivation and depletion conditions, suggesting an important function in stress nutritional situations. These results provide valuable data about the cell division process of these extracellular parasites.Fil: Iriarte, Lucrecia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Martínez, Cristian Iván. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: de Miguel, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Cóceres, Verónica Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentin

Reproducción social y cuidado

El concepto de cuidado ha cobrado creciente importancia en el análisis de las políticas sociales, incluso han surgido nuevas formulaciones como la de regímenes sociales de cuidado o la de organización social del cuidado para aludir a los modos en que se abordan la socialización y atención de personas dependientes en distintos contextos sociopolíticos. En este trabajo discutiremos los alcances del concepto de cuidado en su utilización en el campo del análisis del bienestar. Algunas connotaciones del concepto –a pesar de su surgimiento en el contexto de la crítica feminista a la organización de la producción y reproducción capitalistas– oscurecen su potencialidad crítica.Fil: Iriarte, Natalia. Tribunal Superior de Justicia de la provincia de Córdoba. Poder Judicial de la provincia de Córdoba; Argentina.Fil: Iriarte, Natalia. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Nicora, Valeria. Universidad Nacional de Córdoba. Facultad de Derecho y Ciencias Sociales; Argentina.Fil: Nicora, Valeria. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Britos, Nora. Universidad Nacional de Córdoba. Facultad de Derecho y Ciencias Sociales; Argentina.Fil: Britos, Nora. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina

¿Familiarización o desfamiliarización? La tercerización del cuidado infantil en la ciudad de Córdoba

En Argentina, las instituciones del tercer sector han acrecentado su protagonismo en la provisión de servicios de cuidado infantil en contextos de pobreza. En este trabajo discutimos la vinculación entre Estado y tercer sector, a partir de los resultados de nuestra investigación acerca de las características de la atención a la primera infancia en la ciudad de Córdoba. El estudio se enmarca en una línea de trabajo dedicada a explorar los aportes de los servicios públicos de cuidado infantil a la desfamiliarización del bienestar

Neurocognitive, social cognitive, and clinical predictors of creativity in schizophrenia

Background: Creativity is considered an essential human accomplishment and a key component for daily life problem solving. It has been suggested that impairment in working memory, cognitive flexibility, and theory of mind could lead to lower creativity in schizophrenia. Additionally, other neurocognitive and social cognitive domains, as well as clinical symptoms could play a role in this relationship. However, the extent to which each of these domains influences creativity in schizophrenia remains unknown. Therefore, the aim of this study was to simultaneously investigate the specific contribution of neurocognitive, social cognitive, and clinical variables to creativity in schizophrenia. Methods: One hundred and one patients with schizophrenia were assessed in terms of sociodemographic, clinical, neurocognitive, social cognitive, and creativity variables. Results: After controlling for sociodemographic variables, regression analyses showed that higher social perception (beta = 0.286, p = .004) and processing speed (beta = 0.219, p = .023) predicted creativity total score. Higher social perception (beta = 0.298, p = .002) and processing speed (beta = 0.277, p = .004) explained figural creativity. Finally, lower negative symptoms (beta =-0.302, p = .002) and higher social perception (beta = 0.210, p = .029) predicted verbal creativity. Conclusions: Results suggest that neurocognitive, social cognitive, as well as clinical symptoms influence creativity of patients with schizophrenia. Moreover, these findings point out the prominent role of social cognition in creativity in schizophrenia.This study has been supported by the Spanish Ministry of Economy and Competitiveness (PI16/01022) and the Department of Education and Science of the Basque Government (Team A) (IT946-16). AS was supported by a Fellowship from the Fundacion Tatiana Perez de Guzman el Bueno. The funding agencies had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript

The impact of creativity on functional outcome in schizophrenia: a mediational model

Functional impairment remains one of the most challenging issues for treatment in schizophrenia. However, previous studies have mainly focused on the negative impact of symptoms excluding variables that could positively impact functional outcome, such as creativity, which is considered an adaptive capacity for real-life problem-solving. This study analyzed the predictive role of creativity on functional outcome in 96 patients with schizophrenia through a mediational model, including sociodemographic, clinical, neurocognitive, and social cognitive variables. Path analysis revealed that creativity significantly mediated the relationship between neurocognition and functional outcome, and that creativity mediated between negative symptoms and functional outcome. Additionally, neurocognition was directly associated with functional outcome and social functioning was associated with creativity. The involvement of creativity in functional outcome could have relevant implications for the development of new interventions. These findings open up a new field of research on additional personal resources as possible factors of functional outcome in schizophrenia and other diseases

¿Familiarización o desfamiliarización? La tercerización del cuidado infantil en la ciudad de Córdoba

Fil: González, Cristina. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales. Instituto de Política, Sociedad e Intervención Social; Argentina.Fil: Nicora, María Valeria. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Nicora, María Valeria. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Iriarte, Natalia. Tribunal Superior de Justicia de la provincia de Córdoba. Poder Judicial de la provincia de Córdoba; Argentina.Fil: Iriarte, Natalia. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Torrice, Lucas. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Britos, Nora. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Caro, Rubén. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.En Argentina, las instituciones del tercer sector han acrecentado su protagonismo en la provisión de servicios de cuidado infantil en contextos de pobreza. En este trabajo discutimos la vinculación entre Estado y tercer sector, a partir de los resultados de nuestra investigación acerca de las características de la atención a la primera infancia en la ciudad de Córdoba. El estudio se enmarca en una línea de trabajo dedicada a explorar los aportes de los servicios públicos de cuidado infantil a la desfamiliarización del bienestar.https://revistas.unc.edu.ar/index.php/ConCienciaSocial/article/view/21642info:eu-repo/semantics/acceptedVersionFil: González, Cristina. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales. Instituto de Política, Sociedad e Intervención Social; Argentina.Fil: Nicora, María Valeria. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Nicora, María Valeria. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Iriarte, Natalia. Tribunal Superior de Justicia de la provincia de Córdoba. Poder Judicial de la provincia de Córdoba; Argentina.Fil: Iriarte, Natalia. Universidad Nacional de Córdoba. Secretaría de Ciencia y Tecnología; Argentina.Fil: Torrice, Lucas. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Britos, Nora. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Fil: Caro, Rubén. Universidad Nacional de Córdoba. Facultad de Ciencias Sociales; Argentina.Otras Ciencia Polític

Brain White Matter Correlates of Creativity in Schizophrenia: A Diffusion Tensor Imaging Study

The relationship between creativity and psychopathology has been a controversial research topic for decades. Specifically, it has been shown that people with schizophrenia have an impairment in creative performance. However, little is known about the brain correlates underlying this impairment. Therefore, the aim of this study was to analyze whole brain white matter (WM) correlates of several creativity dimensions in people with schizophrenia. Fifty-five patients with schizophrenia underwent diffusion-weighted imaging on a 3T magnetic resonance imaging machine as well as a clinical and a creativity assessment, including verbal and figural creativity measures. Tract-based spatial statistic, implemented in FMRIB Software Library (FSL), was used to assess whole brain WM correlates with different creativity dimensions, controlling for sex, age, premorbid IQ, and medication. Mean fractional anisotropy (FA) in frontal, temporal, subcortical, brain stem, and interhemispheric regions correlated positively with figural originality. The most significant clusters included the right corticospinal tract (cerebral peduncle part) and the right body of the corpus callosum. Verbal creativity did not show any significant correlation. As a whole, these findings suggest that widespread WM integrity is involved in creative performance of patients with schizophrenia. Many of these areas have also been related to creativity in healthy people. In addition, some of these regions have shown to be particularly impaired in schizophrenia, suggesting that these WM alterations could be underlying the worse creative performance found in this pathology.This study has been supported by the Spanish Ministry of Economy and Competitiveness (PI16/01022) and the Department of Education and Science of the Basque Government (Team A) (IT946-16). AS was supported by a fellowship from the Fundacion Tatiana Perez de Guzman el Bueno. AG-G was supported by a fellowship from the Education, Language, Politics and Culture Department of the Basque Government (PRE_2015_1_0444). The funding agencies had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript

Primer registro de Abrothrix jelskii (Thomas 1824) para Chile

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Cognitive, creative, functional, and clinical symptom improvements in schizophrenia after an integrative cognitive remediation program: a randomized controlled trial

[EN] This study analyzed the effectiveness of an integrative cognitive remediation program (REHACOP) in improving neurocognition, social cognition, creativity, functional outcome, and clinical symptoms in patients with schizophrenia. In addition, possible mediators predicting improvement in functional outcomes were explored. The program combined cognitive remediation with social cognitive training and social and functional skill training over 20 weeks. The sample included 94 patients, 47 in the REHACOP group and 47 in the active control group (occupational activities). Significant differences were found between the two groups in change scores of processing speed, working memory, verbal memory (VM), inhibition, theory of mind, emotion processing (EP), figural creative strengths, functional competence, disorganization, excitement, and primary negative symptoms. A mediational analysis revealed that changes in VM, inhibition, and EP partially explained the effect of cognitive remediation on functional competence improvement. This study provides initial evidence of the effect of integrative cognitive remediation on primary negative symptoms and creativity.This work was supported by the Carlos III Health Institute of the Spanish Ministry of Economy and Competitiveness (PI16/01022); the Department of Education and Science of the Basque Government (Team A) (IT946-16); the Fundacion Tatiana Perez de Guzman el Bueno (to AS); and the University of the Basque Country (UPV/EHU) (PIF 19/40 to MTE). The funding agencies had no role in the design, data collection, and analysis, decision to publish, or preparation of the study. The authors thank all the participants and clinical teams who were involved in this study as well as the English language editing service. Our special thanks to Amaia Ortiz de Zarate, Edorta Elizagarate, and Isabel Hervella for all the support in the recruitment and management of patients