X-Ray Diffraction and structural studies of Cu(II) complex with Gliclazide(N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide),and its hypoglycemic activity

Synthesis and characterization by spectroscopic, X-ray and hypoglycemic activity study of copper complex with gliclazide (N-(hexahydrocyclopenta[c]-pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide) an oral antidiabetic drugs.                         The conductometric titration using monovariation method indicate that complex are non-ionic and L2M (2:1) type. Analytical data agree with the molecular formula (C15H20N3O3S)2Cu. of complex for gliclazide. The structure of complex was assigned square planner supported by IR, 1H-NMR, X-Ray, mass studies and propose structure (I) for complex.Alloxan induced model have been used to compare hypoglycemic activity of gliclazide complex. Keywords: Gliclazide, Oral antidiabetic drugs, Complexes, IR, NMR. X-Ray, Hypoglycemic activity

Optimal Design and Operation of an Industrial Three Phase Reactor for the Oxidation of Phenol

YesAmong several treatment methods Catalytic Wet Air Oxidation (CWAO) treatment is considered as a useful and powerful method for removing phenol from waste waters. In this work, mathematical model of a trickle bed reactor (TBR) undergoing CWAO of phenol is developed and the best kinetic parameters of the relevant reaction are estimated based on experimental data (from the literature) using parameter estimation technique. The validated model is then utilized for further simulation and optimization of the process. Finally, the TBR is scaled up to predict the behavior of CWAO of phenol in industrial reactors. The optimal operating conditions based on maximum conversion and minimum cost in addition to the optimal distribution of the catalyst bed is considered in scaling up and the optimal ratio of the reactor length to reactor diameter is calculated with taking into account the hydrodynamic factors (radial and axial concentration and temperature distribution)

Holography, Fractionalization and Magnetic Fields

Four dimensional gravity with a U(1) gauge field, coupled to various fields in asymptotically anti-de Sitter spacetime, provides a rich arena for the holographic study of the strongly coupled (2+1)-dimensional dynamics of finite density matter charged under a global U(1). As a first step in furthering the study of the properties of fractionalized and partially fractionalized degrees of freedom in the strongly coupled theory, we construct electron star solutions at zero temperature in the presence of a background magnetic field. We work in Einstein-Maxwell-dilaton theory. In all cases we construct, the magnetic source is cloaked by an event horizon. A key ingredient of our solutions is our observation that starting with the standard Landau level structure for the density of states, the electron star limits reduce the charge density and energy density to that of the free fermion result. Using this result we construct three types of solution: One has a star in the infra-red with an electrically neutral horizon, another has a star that begins at an electrically charged event horizon, and another has the star begin a finite distance from an electrically charged horizon.Comment: 18 pages, 2 figures. Submitted to Springer Lecture Notes: Strongly interacting matter in magnetic fields. v2: Updated references and adjusted some phrasing in the introductio

Modified Equations to Calculate Water Content and Refractive Index of Honey Based on Its Total Soluble Solids

The capacity of honey to break light is used for refractometric determination of humidity. In the present work, a manual refractometer was used to measure honey total soluble solids (73% - 86%) which are the corresponding values of refractive indices stated in Chataway’s Table. The relationship between values of total soluble solids, water content and refractive index in the obtained graphics gave equations that could be used directly to calculate both refractive index and water content of honey from its total soluble solids. This simple, fast and easy way could be applied without utilizing expensive refractometers due to their high cost or lack of their usage training. Furthermore, the suggested equation is more accurate than that of the current reference table (i.e. Chataway’s Table) and could be rapidly utilized for calculating water content in honey samples

Robust, Resilient and Reliable Architecture for V2X Communication

The new developments in mobile edge computing (MEC) and vehicle-to-everything (V2X) communications has positioned 5G and beyond in a strong position to answer the market need towards future emerging intelligent transportation systems and smart city applications. The major attractive features of V2X communication is the inherent ability to adapt to any type of network, device, or data, and to ensure robustness, resilience and reliability of the network, which is challenging to realize. In this work, we propose to drive these further these features by proposing a novel robust, resilient and reliable architecture for V2X communication based on harnessing MEC and blockchain technology. A three stage computing service is proposed. Firstly, a hierarchcial computing architecture is deployed spanning over the vehicular network that constitutes cloud computing (CC), edge computing (EC), fog computing (FC) nodes. The resources and data bases can migrate from the high capacity cloud services (furthest away from the individual node of the network) to the edge (medium) and low level fog node, according to computing service requirements. Secondly, the resource allocation filters the data according to its significance, and rank the nodes according to their usability, and selects the network technology according to their physical channel characteristics. Thirdly, we propose a blockchain-based transaction service that ensures reliability. We discussed two use cases for experimental analysis, plug- in electric vehicles in smart grid scenarios, and massive IoT data services for autonomous cars. The results show that car connectivity prediction is accurate 98% of the times, where 92% more data blocks are added using micro-blockchain solution compared to the public blockchain, where it is able to reduce the time to sign and compute the proof-of-work (PoW), and deliver a low-overhead Proof-of-Stake (PoS) consensus mechanism. This approach can be considered a strong candidate architecture for future V2X, and with more general application for everything- to-everything (X2X) communications

Improvement of fuel quality by oxidative desulfurization: Design of synthetic catalyst for the process

YesThe present study explored a novel oxidative desulfurization (ODS) method of light gas oil fuel, which combines a catalytic oxidation step of the dibenzothiophene compound directly in the presence of molecular air as oxidant to obtain high quality fuel for light gas oil. In chemical industries and industrial research, catalysis play a significant role. Heightened concerns for cleaner air together with stricter environmental legislations on sulphur content in addition to fulfill economic have created a driving force for the improvement of more efficient technologies and motivating an intensive research on new oxidative catalysts. As the lower quality fuel becomes more abundant, additional challenges arise such as more severe operation conditions leading to higher corrosion of the refinery installations, catalyst deactivation and poisoning. Therefore, among the technologies to face these challenges is to develop catalysts that can be applied economically under moderate conditions. The objective of this work is to design a suitable synthetic catalyst for oxidative desulfurization (ODS) of light gas oil (LGO) containing model sulphur compound (dibenzothiophene (DBT)) using air as oxidant and operating under different but moderate operating conditions. The impregnation method is used to characterize two homemade catalysts, cobalt oxide (Co3O4/γ-Al2O3) and manganese oxide (MnO2/γ-Al2O3). The prepared catalysts showed that the manganese oxide has a good impregnation (MnO2=13%), good pore size distribution and larger surface area. A set of experiments related to ODS of dibenzothiophene has been carried out in a continuous flow isothermal trickle bed reactor using light gas oil as a feedstock utilizing both catalysts prepared in-house. At constant pressure of 2 bar and with different initial concentration of sulphur within dibenzothiophene, the temperature of the process was varied from 403K to 473K and the liquid hourly space velocity from(LHSV) was varied from 1 to 3 hr-1. The results showed that an increase in reaction temperature and decreasing in LHSV, higher conversion was obtained. Although both catalysts showed excellent catalytic performance on the removal of molecule sulphur compound from light gas oil, the catalyst MnO2 catalyst exhibited higher conversion than Co3O4 catalyst at the same process operating conditions

Significant cost and energy savings opportunities in industrial three phase reactor for phenol oxidation

YesEnergy saving is an important consideration in process design for low cost sustainable production with reduced environmental impacts (carbon footprint). In our earlier laboratory scale pilot plant study of catalytic wet air oxidation (CWAO) of phenol (a typical compound found in wastewater), the energy recovery was not an issue due to small amount of energy usage. However, this cannot be ignored for a large scale reactor operating around 140–160 °C due to high total energy requirement. In this work, energy savings in a large scale CWAO process is explored. The hot and cold streams of the process are paired up using 3 heat exchangers recovering significant amount of energy from the hot streams to be re-used in the process leading to over 40% less external energy consumption. In addition, overall cost (capital and operating) savings of the proposed process is more than 20% compared to that without energy recovery option

Spatial correlators in strongly coupled plasmas

We numerically calculate the spatial correlators of the scalar and pseudoscalar operators $F^2$ and $F\tilde F$, in SU(3) Yang-Mills theory at zero and finite-temperature on the lattice. We compare the results over the distances $\frac{1}{2T}<r<\frac{3}{2T}$ to the free-field prediction, to the operator-product expansion as well as to the strongly coupled large-$N_c$ \sN=4 super-Yang-Mills theory, where results are obtained by AdS/CFT methods. For $T_c<T<1.15T_c$, both channels exhibit stronger spatial correlations than in the vacuum, and we give an explanation for this, using sum-rules and the operator-product expansion. The AdS/CFT calculation provides a semi-quantitatively successful description of the vacuum-subtracted $F^2$ correlator, renormalized in the 3-loop $\overline{\rm MS}$ scheme, in the interval of temperatures $1.2<T/T_c<1.9$, while the free-field prediction has the wrong sign. The $F\tilde F$ and $F^2$ correlators are predicted to have the same functional form both at weak coupling and in the strongly coupled SYM theory. The Yang-Mills plasma does not meet that expectation below $2T_c$. Instead we find that strong fluctuations of $F\tilde F$ are present at least up to that temperature. We discuss the impact of our results on our understanding of the quark-gluon plasma.Comment: 32 pages, 9 figures, 4 tables; added some references, more detailed captions, conclusions unchange

Sub-MICs of Carum copticum and Thymus vulgaris influence virulence factors and biofilm formation in Candida spp

BACKGROUND: Emergence of drug-resistant strains of Candida and inefficiency of conventional antifungal therapy has necessitated the search for alternative and new antifungal agents. Inhibition of virulence and biofilm are the potential drug targets. In this study, the oils of Carum copticum, Thymus vulgaris and their major active compound thymol as revealed by Gas chromatography and gas chromatography–mass spectrometry (GC-GC/MS) analysis were tested for their inhibitory activity against growth to determine sub-MIC values against 27 drug-resistant strains of Candida spp. METHODS: Brothmacrodilution method was used for determination of MIC of test oils against Candida strains. The spectrophotometric methods were used for detection and inhibition assays for virulence factors in Candida spp. Light and electron microscopy was performed to observe morphological effects of oils on biofilms. GC-GC/MS were used to evaluate the major active compounds of test oils. RESULTS: Virulence factors like proteinase and haemolysin were detected in 18 strains, both in solid and liquid media. A 70% of the test strains exhibited hydrophobicity and formed moderate to strong biofilms (OD280 0.5- > 1.0). Test oils exhibited MICs in the range of 45–360 μg.mL−1 against the majority of test strains. All the oils at 0.25× and 0.5× MICs induced >70% reduction in the cell surface hydrophobicity, proteinase and haemolysin production. At 0.5× MIC, thymol and T. vulgaris were most inhibitory against biofilm formation. At sub-MICs electron microscopic studies revealed the deformity of complex structures of biofilms formed and cell membranes appeared to be the target site of these agents. CONCLUSIONS: Therefore, our findings have highlighted the concentration dependent activity of oils of C. copticum and T. vulgaris against virulence factors and biofilms in proteinase and haemolysin producing drug-resistant strains of Candida spp. The above activities of test oils are supposed to be mainly contributed due to their major active compound thymol. Further mechanism involving anti-proteinase, anti-haemolysin and anti-biofilm activities of these oils and compounds are to be explored for possible exploitation in combating Candida infections.The Indian Council of Medical Research, New Delhi for financial support in the form of SRF to M S A Khan.http://www.biomedcentral.com/bmccomplementalternmedam201