Single variable and adjusted regression analyses of covariates (anthropometric and sociodemographic variables) with and without BSID III composite scores to predict WPPSI III and WISC FRI scores.

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Demographic and clinical characteristics of children in the cohort.

<p>^<i>1</i><i>Indian Rupees</i>,</p><p>^<i>2</i><i>One mother is deceased</i>,</p><p>^<i>3</i><i>Childcare center</i></p><p>Demographic and clinical characteristics of children in the cohort.</p

Demographic and clinical characteristics of children in the cohort.

<p>^<i>1</i><i>Indian Rupees</i>,</p><p>^<i>2</i><i>One mother is deceased</i>,</p><p>^<i>3</i><i>Childcare center</i></p><p>Demographic and clinical characteristics of children in the cohort.</p

Hierarchical Regression Analysis for variables predicting total ASQ-3 scores in North Indian children 12–36 months¹.

<p>*** p<.001,</p><p>** p<.01,</p><p>* p<.05,</p><p>¹ For the 422 assessed children, the mean total ASQ-3 score was 231.9 (SD = 50) with scores ranging from a minimum of 30 to a maximum of 300.</p><p>^<i>2</i> All models are adjusted for child characteristics (age, sex and breastfeeding status), and annual family income,</p><p>^<i>3</i> unstandardized Beta coefficient,</p><p>^<i>4</i> standardized regression coefficient, Beta values for model 7 only.</p><p>Hierarchical Regression Analysis for variables predicting total ASQ-3 scores in North Indian children 12–36 months<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0121743#t002fn004" target="_blank">¹</a>.</p

Variables predicting ASQ-3 subscale score in North Indian children 12–36 months¹.

<p>*** p<.001,</p><p>** p<.01,</p><p>* p<.05, logistic regression P-value,</p><p>¹ For the 422 assessed children, the mean subscales scores vary from 44.8 to 47.8, all with a range from 0 to 60.</p><p>Variables predicting ASQ-3 subscale score in North Indian children 12–36 months<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0121743#t003fn004" target="_blank">¹</a>.</p

Associations between log (base2) days of diarrhea and changes in ASQ-scores.

<p>The graphs were constructed using generalized additive models in R, the solid line depicts the association of the total ASQ-score and log (base2) days of diarrhea. The Y-axis is centered on the mean total ASQ-score. The shaded area spans the 95% confidence interval of this association.</p

Concentrations of markers of vitamin B12 and folate status and change compared to the placebo.

<p>¹ Interquartile range.</p><p>² Mean difference change in concentration from baseline.</p><p>³ 95% Confidence interval.</p><p>Concentrations of markers of vitamin B12 and folate status and change compared to the placebo.</p

The effect of vitamin B12 and/or Folic acid on ASQ-3 total and subscale scores.

<p>*p<0.05.</p><p>**p<0.01.</p><p>¹ Mean difference in total ASQ scores from Placebo.</p><p>² 95% Confidence interval.</p><p>The effect of vitamin B12 and/or Folic acid on ASQ-3 total and subscale scores.</p

ORs¹ (95% CIs)² for being in the lower quartile of ASQ-3 total in the intervention group compared with placebo in subgroups.³

<p>*p<0.05.</p><p>¹Odds Ratio.</p><p>²95% Confidence interval.</p><p>³Adjusted for sex, age, breastfeeding status, stunting and Mother`s encouragement of developmental advances (dichotomus).</p><p>ORs<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0129915#t005fn002" target="_blank">¹</a> (95% CIs)<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0129915#t005fn003" target="_blank">²</a> for being in the lower quartile of ASQ-3 total in the intervention group compared with placebo in subgroups.<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0129915#t005fn004" target="_blank">³</a></p

Baseline characteristics of the 422 children age 6–30 months.

<p>¹ Mean±SD all such values.</p><p>² Missing information from 1 child.</p><p>³ Indian Rupees in median (Interquartile range).</p><p>⁴Childcare centre.</p><p>Baseline characteristics of the 422 children age 6–30 months.</p