Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network

Objectives In lupus nephritis the pathological diagnosis from tissue retrieved during kidney biopsy drives treatment and management. Despite recent approval of new drugs, complete remission rates remain well under aspirational levels, necessitating identification of new therapeutic targets by greater dissection of the pathways to tissue inflammation and injury. This study assessed the safety of kidney biopsies in patients with SLE enrolled in the Accelerating Medicines Partnership, a consortium formed to molecularly deconstruct nephritis.Methods 475 patients with SLE across 15 clinical sites in the USA consented to obtain tissue for research purposes during a clinically indicated kidney biopsy. Adverse events (AEs) were documented for 30 days following the procedure and were determined to be related or unrelated by all site investigators. Serious AEs were defined according to the National Institutes of Health reporting guidelines.Results 34 patients (7.2%) experienced a procedure-related AE: 30 with haematoma, 2 with jets, 1 with pain and 1 with an arteriovenous fistula. Eighteen (3.8%) experienced a serious AE requiring hospitalisation; four patients (0.8%) required a blood transfusion related to the kidney biopsy. At one site where the number of cores retrieved during the biopsy was recorded, the mean was 3.4 for those who experienced a related AE (n=9) and 3.07 for those who did not experience any AE (n=140). All related AEs resolved.Conclusions Procurement of research tissue should be considered feasible, accompanied by a complication risk likely no greater than that incurred for standard clinical purposes. In the quest for targeted treatments personalised based on molecular findings, enhanced diagnostics beyond histology will likely be required

earthobservations/wetterdienst: New NOAA GHCN API

Add NOAA GHCN API Fix radar index by filtering out bz2 file

earthobservations/wetterdienst: Fix values coercing

Change integer dtypes in untidy format to float to prevent loosing information when converting unit

earthobservations/wetterdienst: Fix monthly/annual data of DWD observations

Fix monthly/annual data of DWD observation

earthobservations/wetterdienst: Caching solely with fsspec

Fix access to ECCC stations listing using Google Drive storage Remove/replace caching entirely by fsspec (+monkeypatch) Fix bug with DWD interval

earthobservations/wetterdienst: Add Wetterdienst Settings

Add Wetterdienst.Settings to manage general settings like tidy, humanize,... Rename DWD forecast to mosmix Instead of "kind" use "network" attribute to differ between different data products of a provider Change data source of NOAA GHCN after problems with timeouts when reaching the server Fix problem with timezone conversion when having dates that are already timezone awar

earthobservations/wetterdienst: Fix cli

Fix cli error with upgraded click ^8.0 where default False would be converted to "False

earthobservations/wetterdienst: Change some hourly parameter mappings

Improve integrity of dataset, parameter and unit enumerations with further tests Change source of hourly sunshine duration to dataset sun Change source of hourly total cloud cover (+indicator) to dataset cloudines

earthobservations/wetterdienst: Several fixes

Fix missing station ids within values result Add details about time interval for NOAA GHCN stations Fix falsely calculated station distance

earthobservations/wetterdienst: Extend explorer

Extend explorer to use all implemented APIs Fix cli/restapi: return json and use NULL instead of Na