Influence of postcoid syndrome on the quality of training of students of the medical-preventive faculty

The article presents the influence of postcovid syndrome on the quality of education of students of the medical-prophylactic faculty.В статье представлено влияние постковидного синдрома на качество обучения студентов лечебно-профилактического факультета

Assessment of the quality of education of graduates of medical-prophylactic faculty

This article presents and analyzes the survey data on the quality of education of graduates of the treatment-and-prophylactic faculty, which are necessary to improve the learning process.В данной статье представлены и проанализированы данные опроса по качеству образования выпускников лечебно-профилактического факультета, необходимые для улучшения процесса обучения

Mechanisms of metformin action

The article discusses modern hypotheses regarding the mechanisms of metformin action. Metformin has been shown to affect not only carbohydrate metabolism, but also many other cell functionsВ статье рассматриваются современные гипотезы о механизмах действия метформина. Показано, что метформин влияет не только на углеводный обмен, но также и на многие другие функции клеток

Efficiency results of the project to attract applicants to the medical-preventive faculty

The article describes the result of organizing medical quests and quizzes for students from specialized biomedical classes by students of the Ural State Medical University to increase the motivation for choosing the profession of a medical doctor.В статье описаны результаты проведения медицинских квестов и квизов для абитуриентов из профильных медико-биологических классов студентами Уральского государственного медицинского университета для повышения мотивации выбора профессии врача-лечебника

THERMAL TREATMENT METHOD OF WEAR RESISTANT BUSHINGS OF OIL AND GAS EQUIPMENT DRILLING PUMP FROM TOOL CHROMIUM STEELS

FIELD: manufacturing technology. SUBSTANCE: invention relates to production of parts of drilling oil and gas equipment, in particular, cylindrical bushings of drilling pump from steel H12MFL, operating under conditions of abrasive wear, corrosion action and high variable pressure. To achieve technical result, steel is melted in induction furnace, centrifugal casting and heat treatment. Heat treatment includes heating of inner surface of bushing at installation of high-frequency currents to temperatures of 1,050–1,075 °C, holding for 8–10 minutes, cooling with compressed air for 10–20 minutes to temperature not lower than 200 °C, final cooling in tank with water for 3–5 minutes and tempering at 200 °C for 180–220 minutes, wherein after final cooling, cold treatment is carried out at -70 °C for 20 minutes. EFFECT: increased service life of cylinder bushings in 1,5-1,8 times (up to 1,000 hours) and manufacturing cost reduction in 1,5 times.Изобретение относится к области производства деталей бурового нефтегазового оборудования, в частности цилиндровых втулок бурового насоса из стали Х12МФЛ, работающих в условиях абразивного износа, коррозионного воздействия и высоких переменных давлениях. Для увеличения ресурса работы цилиндровых втулок в 1,5-1,8 раза (до 1000 часов) и снижения себестоимости изготовления в 1,5 раза осуществляют выплавку стали в индукционной печи, разливку центробежным путем и термическую обработку. Термическая обработка включает нагрев внутренней поверхности втулки на установке токов высокой частоты до температур 1050-1075°С, выдержку 8-10 мин, охлаждение сжатым воздухом в течение 10-20 мин до температуры не ниже 200°С, окончательное охлаждение в баке с водой в течение 3-5 мин и отпуск при 200°С в течение 180-220 мин, при этом после окончательного охлаждения проводят обработку холодом при - 70°С в течение 20 мин

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein

Ebolaviruses cause severe disease in humans, and identification of monoclonal antibodies (mAbs) that are effective against multiple ebolaviruses are important for therapeutics development. Here we describe a distinct class of broadly neutralizing human mAbs with protective capacity against three ebolaviruses infectious for humans: Ebola (EBOV), Sudan (SUDV), and Bundibugyo (BDBV) viruses. We isolated mAbs from human survivors of ebolavirus disease and identified a potent mAb, EBOV-520, which bound to an epitope in the glycoprotein (GP) base region. EBOV-520 efficiently neutralized EBOV, BDBV, and SUDV and also showed protective capacity in relevant animal models of these infections. EBOV-520 mediated protection principally by direct virus neutralization and exhibited multifunctional properties. This study identified a potent naturally occurring mAb and defined key features of the human antibody response that may contribute to broad protection. This multifunctional mAb and related clones are promising candidates for development as broadly protective pan-ebolavirus therapeutic molecules

Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein.

Ebolaviruses cause severe disease in humans, and identification of monoclonal antibodies (mAbs) that are effective against multiple ebolaviruses are important for therapeutics development. Here we describe a distinct class of broadly neutralizing human mAbs with protective capacity against three ebolaviruses infectious for humans: Ebola (EBOV), Sudan (SUDV), and Bundibugyo (BDBV) viruses. We isolated mAbs from human survivors of ebolavirus disease and identified a potent mAb, EBOV-520, which bound to an epitope in the glycoprotein (GP) base region. EBOV-520 efficiently neutralized EBOV, BDBV, and SUDV and also showed protective capacity in relevant animal models of these infections. EBOV-520 mediated protection principally by direct virus neutralization and exhibited multifunctional properties. This study identified a potent naturally occurring mAb and defined key features of the human antibody response that may contribute to broad protection. This multifunctional mAb and related clones are promising candidates for development as broadly protective pan-ebolavirus therapeutic molecules