The role of histopathologic testing on apocrine carcinoma of the breast

Background: Apocrine carcinoma is a rare primary breast tumor characterized by the apocrine morphology. The purpose of this article is to report a review of cases with apocrine carcinoma and draw physicians' attention to the benefits of immunphenotypic techniques in cases with suspected apocrine morphology in diagnosing this uncommon breast tumor

Case Report - Lingual schwannoma

Schwannomas or neurilemmomas are benign, slow growing, usually solitary and encapsulated tumor, originating from Schwann cells of the nerve sheath. Intraoral schwannoma accounts for 1% of head and neck region and are commonly seen at the base region of tongue. Most of the few such reports in the literature, have described schwannomas that occurred in the tongue. In this article, we report a rare case of lingual schwannoma involving the anterior of tongue, in a young individual, in whom the lesion was completely excised via an intra oral approach

Case Report - Lingual schwannoma

Schwannomas or neurilemmomas are benign, slow growing, usually solitary and encapsulated tumor, originating from Schwann cells of the nerve sheath. Intraoral schwannoma accounts for 1% of head and neck region and are commonly seen at the base region of tongue. Most of the few such reports in the literature, have described schwannomas that occurred in the tongue. In this article, we report a rare case of lingual schwannoma involving the anterior of tongue, in a young individual, in whom the lesion was completely excised via an intra oral approach

Placental findings in malnourished term neonates

Background

Uterine perivascular epithelioid cell tumor coexisting with pulmonary lymphangioleiomyomatosis and renal angiomyolipoma - A case report

We present a case of uterine perivascular epithelioid cell tumor (PEComa) coexisting with both pulmonary lymphangioleiomyomatosis and renal angiomyolipoma. The patient was a 42-year-old woman, suffering from massive abnormal uterine bleeding, progressive dyspnea, and arterial hypertension. Her clinical history included diagnoses of bilateral renal angiomyolipoma and pulmonary lymphangioleiomyomatosis. The patient underwent a subtotal hysterectomy and the specimen contained a subserosal tumor with irregular outlines in addition to uterine leiomyomata. The uterine tumor was histologically composed of solid sheets and tonguelike infiltration and lymphangioleiomyomalike structures within the myometrium, formed by epithelioid cells with ovoid to round nuclei and clear to light eosinophilic cytoplasms. The tumor did not display any morphologic sign of malignancy. The tumor cells showed expression of HMB-45 and smooth muscle markers. Ultrastructural analysis revealed abundant cytoplasmic microfilaments and rare small cytoplasmic bodies with a gridlike lining. We conclude that identification of lymphangioleiomyomalike growth pattern may aid in the differential diagnosis of uterine PEComa and suggest using both PEComa and smooth muscle tumor terminology

PSEUDOANGIOMATOUS STROMAL HYPERPLASIA OF THE BREAST ( MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL ANALYSIS OF 14 CASES).

Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon, benign mesenchymal lesion of the breast. Histologically, it is characterized by complex, anastomosing, empty, slit-like spaces that are lined by spindle cells in a dense collagenous stroma. We have evaluated 14 PASH cases morphologically and immunohistochemically, using antibodies against CD34 and progesterone receptor and reviewed the relevant literature. Also, we have evaluated the mast cell population of the lesions, using Giemsa stain. All of the cases were women presenting with a mass in the breast. The diameter of the lesions ranged from 1 cm to 13,5 cm (mean diameter 4 cm). The spindle cells, lining the slit-like spaces, were immunoreactive for anti CD34 whereas all were negative for anti progesterone receptor. The mean mast cell count was 17,5/10 HPF. Although differential diagnosis of PASH includes several mesenchymal lesions appropriate macroscopic sampling and immunohistochemistry are usually sufficient for proper diagnosis. Nevertheless, detection of immunostaining for CD34, using immunohistochemistry, may support the morphologic diagnosis

Factors related to recurrence after pathological complete response to postoperative chemotherapy in patients with epithelial ovarian cancer

Aims and background. It has been appreciated for some time that the lack of detection of ovarian cancer at clinical and pathological (second-look laparotomy) evaluation is not synonymous with cure. The goal of this study was to define clinical risk factors for recurrence after complete pathological response to postoperative chemotherapy in patients with epithelial ovarian cancer

ATTITUDE TOWARDS COVID-19 VACCINE AND AFFECTING FACTORS IN ADULTS FROM TURKEY

Objective: This study aims to examine the attitude towards COVID-19 Vaccine and its affecting factors in adults from Turkey

The values of intratumoral mast cell count and Ki-67 immunoreactivity index in differential diagnosis of uterine smooth muscle neoplasms

In this study, the role of the count of intratumoral mast cells was examined and compared with the proliferative activity exhibited by Ki-67 indices in the differential diagnosis of uterine smooth muscle tumors. Sixteen cases of leiomyosarcoma, nine cases of atypical leiomyoma and 16 cases of ordinary leiomyoma were included. The pathological features of the cases were determined by reviewing the archive materials including the patient records and hematoxylin-eosin-stained sections. Toluidine blue stain was used to highlight the intratumoral mast cells and they were counted in at least 40 high power fields. A standard streptavidin-biotin method was applied to the sections to highlight the Ki-67 immunoreactive tumor cell nuclei. These proliferative cells were counted in at least 10 high-power fields. Atypical leiomyomas tended to have a higher quantity of intratumoral mast cells than leiomyosarcomas and ordinary leiomyomas (P = 0.027 and P = 0.021, respectively). Leiomyosarcomas tended to have higher Ki-67 immunoreactivity rates than atypical leiomyomas, although the difference was not statistically significant (P = 0.82). We concluded that the quantity of intratumoral mast cells is useful in the differential diagnosis between leiomyosarcomas and atypical leiomyomas, while the cell proliferation rate expressed by Ki-67 immunoreactivity has a limited value