Long-term Outcomes of Paediatric Patients Admitted With Acute Severe Colitis-A Multicentre Study From the Paediatric IBD Porto Group of ESPGHAN

Acute severe colitis (ASC) is associated with significant morbidity in paediatric patients with ulcerative colitis (UC). Most outcome studies in ASC since TNF antagonists became available have focused on the first year after admission. The aim of this study was to characterize the longer-term outcomes of paediatric patients admitted with ASC

Clinical Features and Outcomes of Paediatric Patients With Isolated Colonic Crohn Disease

Adult studies suggest that patients with isolated colonic Crohn disease (L2 CD) exhibit unique characteristics differentiating them from patients with ileo-caecal (L1) CD and ulcerative colitis (UC). We aimed to characterize clinical features and outcomes of paediatric patients with L2. Retrospective data was collected through the Porto Inflammatory Bowel Disease group of the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) on Paediatric patients with L2, L1 or UC at different time-points. Outcome measures included time to first flare, hospital admissions, initiation of anti-tumor necrosis factor-alpha (TNFα) drug, stricture and surgery. Three hundred patients were included: 102 L1, 94 L2 and 104 UC. Rates of hematochezia at presentation were 14.7%, 44.7% and 95.2%, while rates of fever were 12.7%, 26.6% and 2.9%, for patients with L1, L2 and UC, respectively (P  Significant differences are observed in the clinical presentation and outcomes of Paediatric patients with L2, compared to patients with L1 and UC