4,529 research outputs found
Energetics of Propellant Options for High-Power Hall Thrusters
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76265/1/AIAA-16376-173.pd
A translational framework for public health research
<p><b>Background</b></p>
<p>The paradigm of translational medicine that underpins frameworks such as the Cooksey report on the funding of health research does not adequately reflect the complex reality of the public health environment. We therefore outline a translational framework for public health research.</p>
<p><b>Discussion</b></p>
<p>Our framework redefines the objective of translation from that of institutionalising effective interventions to that of improving population health by influencing both individual and collective determinants of health. It incorporates epidemiological perspectives with those of the social sciences, recognising that many types of research may contribute to the shaping of policy, practice and future research. It also identifies a pivotal role for evidence synthesis and the importance of non-linear and intersectoral interfaces with the public realm.</p>
<p><b>Summary</b></p>
<p>We propose a research agenda to advance the field and argue that resources for 'applied' or 'translational' public health research should be deployed across the framework, not reserved for 'dissemination' or 'implementation'.</p>
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals identified two loci strongly associated with measures of central adiposity; these map near TFAP2B (WC, P = 1.9x10(-11)) and MSRA (WC, P = 8.9x10(-9)). A third locus, near LYPLAL1, was associated with WHR in women only (P = 2.6x10(-8)). The variants near TFAP2B appear to influence central adiposity through an effect on overall obesity/fat-mass, whereas LYPLAL1 displays a strong female-only association with fat distribution. By focusing on anthropometric measures of central obesity and fat distribution, we have identified three loci implicated in the regulation of human adiposity
Electron spin dynamics in quantum dots and related nanostructures due to hyperfine interaction with nuclei
We review and summarize recent theoretical and experimental work on electron
spin dynamics in quantum dots and related nanostructures due to hyperfine
interaction with surrounding nuclear spins. This topic is of particular
interest with respect to several proposals for quantum information processing
in solid state systems. Specifically, we investigate the hyperfine interaction
of an electron spin confined in a quantum dot in an s-type conduction band with
the nuclear spins in the dot. This interaction is proportional to the square
modulus of the electron wave function at the location of each nucleus leading
to an inhomogeneous coupling, i.e. nuclei in different locations are coupled
with different strength. In the case of an initially fully polarized nuclear
spin system an exact analytical solution for the spin dynamics can be found.
For not completely polarized nuclei, approximation-free results can only be
obtained numerically in sufficiently small systems. We compare these exact
results with findings from several approximation strategies.Comment: 26 pages, 9 figures. Topical Review to appear in J. Phys.: Condens.
Matte
Metal-insulator transition in a doubly orbitally degenerate model with correlated hopping
In the present paper we propose a doubly orbitally degenerate narrow-band
model with correlated hopping. The peculiarity of the model is taking into
account the matrix element of electron-electron interaction which describes
intersite hoppings of electrons. In particular, this leads to the concentration
dependence of the effective hopping integral. The cases of the strong and weak
Hund's coupling are considered. By means of a generalized mean-field
approximation the single-particle Green function and quasiparticle energy
spectrum are calculated. Metal-insulator transition is studied in the model at
different integer values of the electron concentration. With the help of the
obtained energy spectrum we find energy gap width and criteria of
metal-insulator transition.Comment: minor revisions, published in Phys. Rev.
Branching Fractions of tau Leptons to Three Charged Hadrons
From electron-positron collision data collected with the CLEO detector
operating at CESR near \sqrt{s}=10.6 GeV, improved measurements of the
branching fractions for tau decays into three explicitly identified hadrons and
a neutrino are presented as {\cal
B}(\tau^-\to\pi^-\pi^+\pi^-\nu_\tau)=(9.13\pm0.05\pm0.46)%, {\cal B}(\tau^-\to
K^-\pi^+\pi^-\nu_\tau)=(3.84\pm0.14\pm0.38)\times10^{-3}, {\cal B}(\tau^-\to
K^-K^+\pi^-\nu_\tau)=(1.55\pm0.06\pm0.09)\times10^{-3}, and {\cal B}(\tau^-\to
K^-K^+K^-\nu_\tau)<3.7\times10^{-5} at 90% C.L., where the uncertainties are
statistical and systematic, respectively.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, to appear in Phys. Rev. Let
First Observation of
We report on a study of exclusive radiative decays of the Upsilon(1S)
resonance collected with the CLEO-II detector operating at CESR. We present the
first observation of the radiative decays Upsilon(1S)->gamma pi+pi- and
Upsilon(1S)->gamma pi0pi0. For the dipion mass regime m(pipi)>1.0 GeV, we
obtain Br(Upsilon(1S)->gamma pi+pi-=(6.3+/-1.2+/-1.3) x 10^(-5), and
Br(Upsilon(1S)->gamma pi0pi0=(1.7+/-0.6+/-0.3) x 10^(-5). The observed gamma
pipi events are consistent with the hypothesis Upsilon(1S)->gamma f2(1270).Comment: 9 pages, postscript file also available through
http://w4.lns.cornell.edu/public/CLN
The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells
X-inactivation, the molecular mechanism enabling dosage compensation in mammals, is tightly controlled during mouse early embryogenesis. In the morula, X-inactivation is imprinted with exclusive silencing of the paternally inherited X-chromosome. In contrast, in the post-implantation epiblast, X-inactivation affects randomly either the paternal or the maternal X-chromosome. The transition from imprinted to random X-inactivation takes place in the inner cell mass (ICM) of the blastocyst from which embryonic stem (ES) cells are derived. The trigger of X-inactivation, Xist, is specifically downregulated in the pluripotent cells of the ICM, thereby ensuring the reactivation of the inactive paternal X-chromosome and the transient presence of two active X-chromosomes. Moreover, Tsix, a critical cis-repressor of Xist, is upregulated in the ICM and in ES cells where it imposes a particular chromatin state at the Xist promoter that ensures the establishment of random X-inactivation upon differentiation. Recently, we have shown that key transcription factors supporting pluripotency directly repress Xist and activate Tsix and thus couple Xist/Tsix control to pluripotency. In this manuscript, we report that Rnf12, a third X-linked gene critical for the regulation of X-inactivation, is under the control of Nanog, Oct4 and Sox2, the three factors lying at the heart of the pluripotency network. We conclude that in mouse ES cells the pluripotency-associated machinery exerts an exhaustive control of X-inactivation by taking over the regulation of all three major regulators of X-inactivation: Xist, Tsix, and Rnf12
Measurement of the Boson Mass
A measurement of the mass of the boson is presented based on a sample of
5982 decays observed in collisions at
= 1.8~TeV with the D\O\ detector during the 1992--1993 run. From a
fit to the transverse mass spectrum, combined with measurements of the
boson mass, the boson mass is measured to be .Comment: 12 pages, LaTex, style Revtex, including 3 postscript figures
(submitted to PRL
Search for a Fourth Generation Charge -1/3 Quark via Flavor Changing Neutral Current Decay
We report on a search for pair production of a fourth generation charge -1/3
quark (b') in pbar p collisions at sqrt(s) = 1.8 TeV at the Fermilab Tevatron
using an integrated luminosity of 93 pb^-1. Both quarks are assumed to decay
via flavor changing neutral currents (FCNC). The search uses the signatures
gamma + 3 jets + mu-tag and 2 gamma + 2 jets. We see no significant excess of
events over the expected background. We place an upper limit on the production
cross section times branching fraction that is well below theoretical
expectations for a b' quark decaying exclusively via FCNC for b' quark masses
up to m(Z) + m(b).Comment: Eleven pages, two postscript figures, submitted to Physical Review
Letter
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