DataSheet1_Salivary miRNAs as auxiliary liquid biopsy biomarkers for diagnosis in patients with oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis.docx

Objective: The healthcare system needs a novel approach to improve and diagnose early oropharyngeal squamous cell carcinoma against its low survival rate. We conduct a systematic review and a comprehensive meta-analysis for the diagnostic role of blood and salivary microRNAs (miRNAs).Methods: An unbiased and thorough literature search in PubMed yielded appropriate data from qualified articles regarding different miRNA biomarkers, method of extraction, research location, and year of publication. Stata was used to calculate the sensitivity, specificity, diagnostic odds ratio, and summary receiver operating characteristic curve.Results: We included 9 studies with 399 qualified oropharyngeal squamous cell carcinoma patients, which yielded a high diagnostic accuracy of blood miRNAs in combination with salivary miRNAs with a sensitivity of 0.70 (p Conclusion: Combined blood- and saliva-derived miRNAs demonstrated a high diagnostic accuracy in detecting oropharyngeal squamous cell carcinoma.Systematic review registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024509424.</p

Disentangling the effects of entrepreneurs’ passion and perfectionism on their eudaimonic well-being

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Theoretical Insights into the Effects of KOH Concentration and the Role of OH^– in the Electrocatalytic Reduction of CO₂ on Au

The active and selective electrochemical reduction of CO2 to value-added chemical intermediates can offer a sustainable route for the conversion of CO2 to chemicals and fuels, thus helping to mitigate greenhouse gas emissions and enabling intermittent energy from renewable sources. Alkaline solutions are often the preferred media for the electrocatalytic CO2 reduction reaction (CO2RR) as they provide high current densities and low overpotentials while suppressing the hydrogen evolution side reaction. Recent experiments carried out on Au and Ag in KOH, as well as other electrolytes, including KHCO3, K2CO3, and KCl, showed that increasing electrolyte concentration lowered onset potentials, increased Faradaic efficiencies to CO, and improved current densities. Herein, we carry out potential-dependent ab initio molecular dynamic (AIMD) simulations along with density functional theory (DFT) calculations using explicit KOH electrolyte and H2O solution molecules to examine the influence of OH– anions and the KOH electrolyte on the elementary steps and their corresponding energetics in the mechanism for CO2 reduction. The simulations indicate that the first electron transfer step to CO2 to form the adsorbed *CO2(•−) radical anion is rate-limiting, while the subsequent proton and electron transfer steps are facile and downhill in energy at reducing potentials. The OH– anions present in the solution can adsorb on the Au cathode down to potentials as low as ∼ −3 V (SCE). This enables the OH– anions to transfer electrons to the Au cathode and into antibonding 2π* orbitals of CO2, thus facilitating the rate-determining adsorption and electron transfer to CO2 to form the adsorbed *CO2(•−) radical anion. Increasing the concentration of the K+OH– electrolyte reduces the barrier for the electrocatalytic reduction of CO2 and thus improves the current density, consistent with the reported experimental results. The *CO2(•−) radical anion that forms subsequently undergoes facile proton transfer from a vicinal water molecule in solution to form the hydroxy carbonyl (*HOCO) intermediate that readily undergoes subsequent proton and electron transfer from a second water molecule to form CO and OH– at a potential of ∼ −1.2 V SCE. While the formation of formate (HCOO–) is thermodynamically favorable, the direct hydrogenation of *CO2(•−) as well as the intramolecular proton transfer via *HOCO to form HCOO– are kinetically unfavored. The presence of OH– anions near the surface also facilitates the formation of bicarbonate (HCO3–) at lower potentials. The bicarbonate that forms can be converted to the reactive *HOCO intermediate at more negative potentials that subsequently reacts to form CO and regenerate OH–. The results discussed herein help provide a more detailed understanding of the interplay between the OH–, K+, H2O, and reaction intermediates on the Au surface in the electric double layer and their influence on the onset potential, electrocatalytic activity, and selectivity for CO2RR

Maximum likelihood tree comparing DENV-1 complete E gene sequences (1485 base pairs).

<p>Strain names and respective genotypes are given including locally transmitted viruses (Townsville, Cairns, and Mareeba). GenBank accession numbers of retrieved global strains are shown in brackets. Bootstrap support values derived from 1,000 replicate NJ trees are represented for principal nodes >70%. DENV-2 strain Townsville 2004 was used as an outgroup control.</p

Local area of the case's workplace.

<p>Shown are: the case's workplace (cross in circle), containerised cargo delivery locations (dash in circle), apron boundaries (dashed line), southern airport boundary (dot and dash line), airplane arrival areas (airplane symbol), routine adult mosquito traps (red circle), and extra case adult mosquito traps (green circle). Image supplied courtesy of Northern Territory Government.</p

COVID-19 Host Genetics Initiative. A first update on mapping the human genetic architecture of COVID-19

The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.</p