The history of the exegesis of Acts in the early Greek church, based on the Catena to Acts.

Thesis (Ph.D.)--Boston Universit

Ulster Scots – You’ve been framed!

This article looks at the ways in which the work of the French philosopher and art historian, Georges Didi-Huberman, can contribute to our understanding of the techniques used by those who have sought to “invisibilise” Ulster-Scots culture and heritage. In Peuples exposés, peuples figurants (2012), he explores a number of conceptual tools with which to tackle the side-lining of those belonging to what he calls a “peuple figurant” (a people of extras). In particular, he points to frames that allow us to address what one commentator calls the “déficit de représentation” (representation deficit) which comes about as a result. Re-examining material produced in or about Ulster-Scots areas from such a perspective will allow us to uncover Ulster-Scots related content that has hitherto remained invisible.Cet article explore la façon dont l’œuvre de Georges Didi-Huberman, philosophe et historien de l’art, peut nous aider à comprendre les techniques employées par ceux qui ont cherché à « invisibiliser » la culture et l’héritage ulster-scots. Didi-Huberman, surtout dans son Peuples exposés, peuples figurants (2012), propose une série d’outils conceptuels qui mettent en évidence les mécanismes qui conduisent à la marginalisation de ceux qui appartiennent à ce qu’il appelle un « peuple figurant ». En outre, il soulève des interrogations qui nous permettent d’intervenir pour rectifier ce qu’un critique appelle le « déficit de représentation » qui en résulte. De tels cadres nous amèneront à réévaluer la production culturelle qui émane des régions où l’héritage ulster-scots est fortement implanté afin d’identifier des contenus ulster-scots restés jusqu’alors invisibles

A selection of Ulster-Scots writing

The idea behind this section is to give those who have had little or no contact with this tradition an idea of some of the dominant themes and styles in Ulster-Scots writing. A range of material – poetry, prose and the theatre – has been chosen from the beginning of the nineteenth century up until today. It is in no sense an attempt at an anthology. Those interested should see Frank Ferguson (ed.), Ulster-Scots Writing, An Anthology, Dublin, Four Courts, 20..

Karine Deslandes, Regards français sur le conflit nord-irlandais

This book, which is the fifth volume in the “Studies in Franco-Irish Relations” series edited by Eamon Maher, is an extremely interesting and useful examination of the coverage of the Northern Ireland conflict in the French press over the period running from 1969 to the signing of the Belfast Agreement in 1998. The text is based on research carried out at the University of Ulster (Coleraine). It looks at the way the French papers approach the Northern Irela..

GP Benchmark: Engineering a Crowd-Sourcing Platform for Real-Time Understanding of Personality and Cognitive Biases in Clinical Error

Errors in medicine are a significant problem, highlighted as a global safety priority. General Practice is one clinical arena where error is more likely due to clinical decisions being made on a background of clinical complexity, undifferentiated symptoms and diseases, and multiple other factors as yet unquantified. Interventions designed to reduce error are either underutilised, untested, fail to produce lasting results, are designed on inadequate knowledge, or have failed to appreciate the interaction of multiple factors, both cognitive and systemic. We present a potential solution, in the form of GP Benchmark. GP Benchmark is an online simulation environment and tool designed to test clinical decision making in a group of practicing General Practitioners. Its aim is to address two pressing requirements: 1) the need to capture clinical decision making in real-time, in the context of personality, cognitive bias and environmental factors, and 2) the need to provide a validated platform that models the clinical environment so future intervention decisions may be tested without risking patient safety. We highlight the requirements satisfied for implementing GP Benchmark, the plans for validation, and discuss how GP Benchmark will be used to identify further requirements necessary to develop the environment into a tool for testing clinical decision support systems and error prevention strategies

Sequential Sampling Models of Choice: Some Recent Advances

Choice models in marketing and economics are generally derived without specifying the underlying cognitive process of decision making. This approach has been successfully used to predict choice behavior. However, it has not much to say about such aspects of decision making as deliberation, attention, conflict, and cognitive limitations and how these influence choices. In contrast, sequential sampling models developed in cognitive psychology explain observed choices based on assumptions about cognitive processes that return the observed choice as the terminal state. We illustrate three advantages of this perspective. First, making explicit assumptions about underlying cognitive processes results in measures of deliberation, attention, conflict, and cognitive limitation. Second, the mathematical representations of underlying cognitive processes imply well documented departures from Luce’s Choice Axiom such as the similarity, compromise, and attraction effects. Third, the process perspective predicts response time and thus allows for inference based on observed choices and response times. Finally, we briefly discuss the relationship between these cognitive models and rules for statistically optimal decisions in sequential designs

Tightwads and spendthrifts.

Consumers often behave differently than they would ideally like to behave. We propose that an anticipatory pain of paying drives "tightwads" to spend less than they would ideally like to spend. "Spendthrifts," by contrast, experience too little pain of paying and typically spend more than they would ideally like to spend. This article introduces and validates the "spendthrift-tightwad" scale, a measure of individual differences in the pain of paying. Spending differences between tightwads and spendthrifts are greatest in situations that amplify the pain of paying and smallest in situations that diminish the pain of paying. They were so skewed and squint-eyed in their minds, their misering or extravagance mocked all reason. (Dante's Inferno, "Canto VII: The Hoarders and the Wasters") E conomic models of decision making are consequentialist in nature. They assume that decision makers choose between alternative courses of action based on a cognitive evaluation of the desirability (i.e., "utility") and likelihood of their consequences. This does not, however, imply that consequentialist decision makers are devoid of *Scott I. Rick ([email protected]) is a visiting professor of operations and information management at the Wharton School, University of Pennsylvania

Tightwads and spendthrifts.

Consumers often behave differently than they would ideally like to behave. We propose that an anticipatory pain of paying drives "tightwads" to spend less than they would ideally like to spend. "Spendthrifts," by contrast, experience too little pain of paying and typically spend more than they would ideally like to spend. This article introduces and validates the "spendthrift-tightwad" scale, a measure of individual differences in the pain of paying. Spending differences between tightwads and spendthrifts are greatest in situations that amplify the pain of paying and smallest in situations that diminish the pain of paying. They were so skewed and squint-eyed in their minds, their misering or extravagance mocked all reason. (Dante's Inferno, "Canto VII: The Hoarders and the Wasters") E conomic models of decision making are consequentialist in nature. They assume that decision makers choose between alternative courses of action based on a cognitive evaluation of the desirability (i.e., "utility") and likelihood of their consequences. This does not, however, imply that consequentialist decision makers are devoid of *Scott I. Rick ([email protected]) is a visiting professor of operations and information management at the Wharton School, University of Pennsylvania

In silico design of novel probes for the atypical opioid receptor MRGPRX2

The primate-exclusive MRGPRX2 G protein-coupled receptor (GPCR) has been suggested to modulate pain and itch. Despite putative peptide and small molecule MRGPRX2 agonists, selective nanomolar potency probes have not yet been reported. To identify a MRGPRX2 probe, we first screened 5,695 small molecules and found many opioid compounds activated MRGPRX2, including (−)- and (+)-morphine, hydrocodone, sinomenine, dextromethorphan and the prodynorphin-derived peptides, dynorphin A, dynorphin B, and α- and β-neoendorphin. We used these to select for mutagenesis-validated homology models and docked almost 4 million small molecules. From this docking, we predicted ZINC-3573, which represents a potent MRGPRX2-selective agonist, showing little activity against 315 other GPCRs and 97 representative kinases, and an essentially inactive enantiomer. ZINC-3573 activates endogenous MRGPRX2 in a human mast cell line inducing degranulation and calcium release. MRGPRX2 is a unique atypical opioid-like receptor important for modulating mast cell degranulation, which can now be specifically modulated with ZINC-3573