Direct numerical simulation of open-channel flow over smooth-to-rough and rough-to-smooth step changes

Direct numerical simulations (DNS) are reported for open-channel flow over streamwise-alternating patches of smooth and fully rough walls. The rough patch is a three-dimensional sinusoidal surface. Owing to the streamwise periodicity, the flow configuration consists of a step change from smooth to rough, and a step change from rough to smooth. The friction Reynolds number varies from 437 over the smooth patch to 704 over the rough patch. Through the fully resolved DNS dataset it is possible to explore many detailed aspects of this flow. Two aspects motivate this work. The first one is the equilibrium assumption that has been widely used in both experiments and computations. However, it is not clear where this assumption is valid. The detailed DNS data reveal a significant departure from equilibrium, in particular over the smooth patch. Over this patch, the mean velocity is recovered up to the beginning of the log layer after a fetch of five times the channel height. However, over the rough patch, the same recovery level is reached after a fetch of two times the channel height. This conclusion is arrived at by assuming that an error of up to 5 % is acceptable and the log layer, classically, starts from 30 wall units above the wall. The second aspect is the reported internal boundary-layer (IBL) growth rates in the literature, which are inconsistent with each other. This is conjectured to be partly caused by the diverse IBL definitions. Five common definitions are applied for the same DNS dataset. The resulting IBL thicknesses are different by 100 %, and their apparent power-law exponents are different by 50 %. The IBL concept, as a layer within which the flow feels the surface underneath, is taken as the basis to search for the proper definition. The definition based on the logarithmic slope of the velocity profile, as proposed by Elliot (Trans. Am. Geophys. Union, vol. 39, 1958, pp. 1048–1054), yields better consistency with this concept based on turbulence characteristics

Fe, Zn, Mn and N transfer between size classes in a coastal phytoplankton community: Trace metal and major nutrient recycling compared

Experiments were performed to investigate transfer of 59Fe, 65Zn, 54Mn, and 15N from labeled cyanobacteria to the large (\u3e8 μm or \u3e5 μm) phytoplankton size class from Monterey Bay, California. Transfer of metal isotope activity was measured from and into total (for all isotopes) and intracellular (59Fe only) pools. Results demonstrated rapid and efficient transfer of nitrogen to the large phytoplankton size class; intracellular 59Fe was transferred into the intracellular and total pools of the \u3e8 μm phytoplankton size class 70% and 130% as efficiently as nitrogen, respectively. 65Zn and 54Mn were transferred between size classes 48% and 23% as efficiently as N. Extracellular 59Fe and 65Zn from the added cyanobacteria also appeared quickly in the large size fraction, although most of the Fe transfer appeared to be the result of surface adsorption rather than biological uptake. These data are discussed in relation to the biological recycling efficiencies of the four elements and the resulting implications for biogeochemical cycling of trace and major nutrient elements

Reception of laser generated ultrasound from a CFRP plate by an air matched piezoelectric composite transducer

Laser generated ultrasound is being investigated [1,2] for testing structures made of both conventional metals and carbon fibre reinforced polymer (CFRP). Laser interferometers are widely used in such work to detect the normal surface motion caused by ultrasonic pulses. Interferometers offer non-contact, remote and high-fidelity detection, together with a potential to cover large areas rapidly by optical scanning. However their cost is high and only in testing large and/or expensive structures may the cost be justified. A lower cost alternative, but with some compromise on the virtues of an interferometer, would be to use an air transducer as a receiver

Ultrasonic Evaluation of Polymers and Composites Using Air-Coupled Capacitance Transducres

It is often necessary to evaluate materials using non-contact ultrasonic techniques, for example when the test sample is hot, moving, or highly absorbent to conventional fluid couplants. Several non-contact methods are available, such as various optical techniques [1–3], which are generally expensive and require the sample to have optimized optical characteristics. Electro-magnetic acoustic transducers (EMATs) [4,5] and capacitance devices [6] may be used, but require an electrically conductive sample, and a small stand-off distance of a few millimeters or less. There has been much interest recently in the use of air-coupled transducers [7], which may be piezoelectric, using piezopolymers such as PVDF [8], piezocomposites of PZT and epoxy [9,10], or piezoceramics with impedance matching layers on the transducer face [11]. Another type of device is the electrostatic or capacitance transducer [12,13], which consists of a metallized polymer membrane against a backplate electrode to which a bias voltage is applied. Motion of the membrane causes the charge on the backplate to change, which may be detected using a suitable charge amplifier. These devices in general have a wider bandwidth than their piezoelectric counterparts, and improved sensitivity. The backplates are usually mechanically roughened metal, and it is therefore difficult to manufacture two identical devices. However, using a silicon backplate [14–17] and standard etching techniques, the surface of the backplate may be precisely controlled. Such a device is shown schematically in Figure 1. The backplate consists of a silicon wafer into which pits 40μm in diameter and 80μm apart have been anisotropically etched to a depth of approximately 40μm. A gold electrode is then evaporated onto the backplate, and a thin metallized polymer membrane is then placed next to the plate

Defect Detection and Imaging in Composite Structures Using Magnetostrictive Patch Transducers

The use of thin magnetostrictive patches to generate and detect guided waves within the composite samples is investigated for defect detection. This approach has been implemented using SH0 shear horizontal guided waves in both CFRP and GFRP plates. A magnetostrictive patch transducer was able to generate SH0 waves with known directional characteristics. The synthetic aperture focusing technique (SAFT) was then used to reconstruct images of defects using multiple transmission and detection locations. The results for imaging defects in both types of material are presented.“NDTonAIR” Marie Skłodowska Curie Training Network in Non-Destructive Testing and Structural Health Monitoring of Aircraft structures (MSCA-ITN) under the action H2020-MSCA-ITN-2016- under Grant number 722134

Research Center for Quantitative Renal Imaging

poster abstractMission: The mission of the Research Center for Quantitative Renal Imaging is to provide a focused research environment and resource for the development, implementation, and dissemination of innovative, quantitative imaging methods designed to assess the status of and mechanisms associated with acute and chronic kidney disease and evaluate efficacy of therapeutic interventions. Nature of the Center: This Research Center provides a formal mechanism to link research programs focused on understanding the fundamental mechanisms associated with kidney diseases with those associated with the development of advanced imaging methods and quantitative analyses into a focused effort dedicated toward the development and implementation of quantitative renal imaging methods. Goals of the IUPUI Research Center for Quantitative Renal Imaging: Identify, develop, and implement innovative imaging methods that provide quantitative imaging biomarkers for assessing and inter-relating renal structure, function, hemodynamics and underlying tissue micro-environmental factors contributing to kidney disease. Establish an environment that facilitates and encourages interdisciplinary collaborations among investigators and offers research support to investigators focused on developing and utilizing innovative quantitative imaging methods in support of kidney disease research. Provide a resource to inform the greater research and healthcare communities of advances in quantitative renal imaging and its potential for enhanced patient management and care. Offer an imaging research resource to companies engaged in product development associated with the diagnosis and treatment of kidney diseases. Further Information: For further information regarding the IUPUI Research Center for Quantitative RenalImaging and its funding programs please visit http://www.renalimaging.iupui.edu/ or contact the Center at [email protected]. Acknowledgments: The IUPUI Research Center for Quantitative Renal Imaging is supported by contributions from the IUPUI Signature Center Initiative, the Department of Radiology & Imaging Sciences; the Division of Nephrology, the IUPUI School of Science, the IUPUI School of Engineering & Technology, and the Indiana Clinical and Translational Sciences Institute (CTSI)

Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection Versus Insulin Alone in Type 2 Diabetes

Context Glucagon-like peptide-1 (GLP-1) and the clinically available GLP-1 agonists have been shown to exert effects on the heart. It is unclear whether these effects occur at clinically used doses in vivo in humans, possibly contributing to CVD risk reduction. Objective To determine whether liraglutide at clinical dosing augments myocardial glucose uptake alone or in combination with insulin compared to insulin alone in metformin-treated Type 2 diabetes mellitus. Design Comparison of myocardial fuel utilization after 3 months of treatment with insulin detemir, liraglutide, or combination detemir+liraglutide. Setting Academic hospital Participants Type 2 diabetes treated with metformin plus oral agents or basal insulin. Interventions Insulin detemir, liraglutide, or combination added to background metformin Main Outcome Measures Myocardial blood flow, fuel selection and rates of fuel utilization evaluated using positron emission tomography, powered to demonstrate large effects. Results We observed greater myocardial blood flow in the insulin-treated groups (median[25th, 75th percentile]: detemir 0.64[0.50, 0.69], liraglutide 0.52[0.46, 0.58] and detemir+liraglutide 0.75[0.55, 0.77] mL/g/min, p=0.035 comparing 3 groups and p=0.01 comparing detemir groups to liraglutide alone). There were no evident differences between groups in myocardial glucose uptake (detemir 0.040[0.013, 0.049], liraglutide 0.055[0.019, 0.105], detemir+liraglutide 0.037[0.009, 0.046] µmol/g/min, p=0.68 comparing 3 groups). Similarly there were no treatment group differences in measures of myocardial fatty acid uptake or handling, and no differences in total oxidation rate. Conclusions These observations argue against large effects of GLP-1 agonists on myocardial fuel metabolism as mediators of beneficial treatment effects on myocardial function and ischemia protection

Design and development of a novel upper-limb cycling prosthesis

The rise in popularity of the Paralympics in recent years has created a need for effective, low-cost sports-prosthetic devices for upper-limb amputees. There are various opportunities for lower-limb amputees to participate in cycling; however, there are only few options for those with upper-limb amputations. If the individual previously participated in cycling, a cycling-specific prosthesis could allow these activities to be integrated into rehabilitation methods. This article describes the processes involved with designing, developing and manufacturing such a prosthesis. The fundamental needs of people with upper-limb amputation were assessed and realised in the prototype of a transradial terminal device with two release mechanisms, including a sliding mechanism (for falls and minor collisions) and clamping mechanism (for head-on collisions). The sliding mechanism requires the rider to exert approximately 200 N, while the clamping mechanism requires about 700 N. The force ranges can be customised to match rider requirements. Experiments were conducted in a controlled environment to demonstrate stability of the device during normal cycling. Moreover, a volunteer test-rider was able to successfully activate the release mechanism during a simulated emergency scenario. The development of this prosthesis has the potential to enable traumatic upper-limb amputees to participate in cycling for rehabilitation or recreation