Compounds from fermented noni exudates (fNE) selectively kill human cancer cells

Our recent studies involving fermented noni exudates (fNE) made from noni (Morinda citrifolia) have shown promising anti-cancer activities. Using an in vitro cell culture system, this study examines dozens of compounds isolated from fNE in order to identify specific compounds preferentially toxic to tumor cells. The compounds at concentrations of 20, 5, or 2 μg/ml were added to NL-20 non-tumor lung cells or A549 lung carcinoma cells and incubated for 48 hours. The cytotoxicity of the compounds on the cells was measured using the MTS cell proliferation assay. Several compounds were found selectively effective in killing more A549 tumor cells than NL-20 cells. An antioxidant assay was then performed to investigate if a correlation exists between antioxidant activity and selective cancer cell killing in our samples. We found that samples BGS, C2, BGL, and C1 had the highest amount of antioxidant activity. Of these samples, only C2 showed significant selective A549 cell killing (p\u3c.05 at 2μg/ml). Further testing is necessary to determine the mechanism of action and its possible role in immune activation

Non-locality in quantum field theory due to general relativity

We show that general relativity coupled to a quantum field theory generically leads to non-local effects in the matter sector. These non-local effects can be described by non-local higher dimensional operators which remarkably have an approximate shift symmetry. When applied to inflationary models, our results imply that small non-Gaussianities are a generic feature of models based on general relativity coupled to matter fields. However, these effects are too small to be observable in the cosmic microwave background

Unitarity bounds on low scale quantum gravity

We study the unitarity of models with low scale quantum gravity both in four dimensions and in models with a large extra-dimensional volume. We find that models with low scale quantum gravity have problems with unitarity below the scale at which gravity becomes strong. An important consequence of our work is that their first signal at the Large Hadron Collider would not be of a gravitational nature such as graviton emission or small black holes, but rather linked to the mechanism which fixes the unitarity problem. We also study models with scalar fields with non minimal couplings to the Ricci scalar. We consider the strength of gravity in these models and study the consequences for inflation models with non-minimally coupled scalar fields. We show that a single scalar field with a large non-minimal coupling can lower the Planck mass in the TeV region. In that model, it is possible to lower the scale at which gravity becomes strong down to 14 TeV without violating unitarity below that scale.Comment: 15 page

Neutral carbon in the protoplanetary nebulae CRL 618 and CRL 2688

The 609u 3P1 -> 3P0 line of neutral atomic carbon has been detected in the protoplanetary nebulae CRL 618 and CRL 2688. CI appears to be about 7% as abundant as CO in CRL 2688, and 70% as abundant as CO in CRL 618. CI emission arises primarily from the slow component of the wind from these objects. The data presented here indicate that CI gradually becomes more abundant as the star leaves the AGB, and CI is significantly enhanced relative to CO before the star develops a large HII region.Comment: 7 pages, LaTex AASTeX macros. To appear in ApJ Letter

Hotspots for social and ecological impacts from freshwater stress and storage loss

Humans and ecosystems are deeply connected to, and through, the hydrological cycle. However, impacts of hydrological change on social and ecological systems are infrequently evaluated together at the global scale. Here, we focus on the potential for social and ecological impacts from freshwater stress and storage loss. We find basins with existing freshwater stress are drying (losing storage) disproportionately, exacerbating the challenges facing the water stressed versus non-stressed basins of the world. We map the global gradient in social-ecological vulnerability to freshwater stress and storage loss and identify hotspot basins for prioritization (n = 168). These most-vulnerable basins encompass over 1.5 billion people, 17% of global food crop production, 13% of global gross domestic product, and hundreds of significant wetlands. There are thus substantial social and ecological benefits to reducing vulnerability in hotspot basins, which can be achieved through hydro-diplomacy, social adaptive capacity building, and integrated water resources management practices

Conformational transitions of heteropolymers in dilute solutions

In this paper we extend the Gaussian self-consistent method to permit study of the equilibrium and kinetics of conformational transitions for heteropolymers with any given primary sequence. The kinetic equations earlier derived by us are transformed to a form containing only the mean squared distances between pairs of monomers. These equations are further expressed in terms of instantaneous gradients of the variational free energy. The method allowed us to study exhaustively the stability and conformational structure of some periodic and random aperiodic sequences. A typical phase diagram of a fairly long amphiphilic heteropolymer chain is found to contain phases of the extended coil, the homogeneous globule, the micro-phase separated globule, and a large number of frustrated states, which result in conformational phases of the random coil and the frozen globule. We have also found that for a certain class of sequences the frustrated phases are suppressed. The kinetics of folding from the extended coil to the globule proceeds through non-equilibrium states possessing locally compacted, but partially misfolded and frustrated, structure. This results in a rather complicated multistep kinetic process typical of glassy systems.Comment: 15 pages, RevTeX, 20 ps figures, accepted for publication in Phys. Rev.

Comparative Absorption and Emission Abundance Analyses of Nebulae: Ion Emission Densities for IC 418

Recent analyses of nebular spectra have resulted in discrepant abundances from CNO forbidden and recombination lines. We consider independent methods of determining ion abundances for emission nebulae, comparing ion emission measures with column densities derived from resonance absorption lines viewed against the central star continuum. Separate analyses of the nebular emission lines and the stellar UV absorption lines yield independent abundances for ions, and their ratio can be expressed in terms of a parameter n_e_{em}, the ``emission density'' for each ion. Adequate data for this technique are still scarce, but separate analyses of spectra of the planetary nebula and central star of IC 418 do show discrepant abundances for several ions, especially Fe II. The discrepancies are probably due to the presence of absorbing gas which does not emit and/or to uncertain atomic data and excitation processes, and they demonstrate the importance of applying the technique of combining emission- and absorption-line data in deriving abundances for nebulae.Comment: 25 pages, 3 figures, accepted for publication in PAS

Poor correlation between large-scale environmental flow violations and freshwater biodiversity: implications for water resource management and the freshwater planetary boundary

The freshwater ecosystems around the world are degrading, such that maintaining environmental flow1 (EF) in river networks is critical to their preservation. The relationship between streamflow alterations (subsequent EF violations2) and the freshwater biodiversity response is well established at the scale of stream reaches or small basins (∼&lt;100 km2). However, it is unclear if this relationship is robust at larger scales, even though there are large-scale initiatives to legalize the EF requirement. Moreover, EFs have been used in assessing a planetary boundary3 for freshwater. Therefore, this study intends to conduct an exploratory evaluation of the relationship between EF violation and freshwater biodiversity at globally aggregated scales and for freshwater ecoregions. Four EF violation indices (severity, frequency, probability of shifting to a violated state, and probability of staying violated) and seven independent freshwater biodiversity indicators (calculated from observed biota data) were used for correlation analysis. No statistically significant negative relationship between EF violation and freshwater biodiversity was found at global or ecoregion scales. These findings imply the need for a holistic bio-geo-hydro-physical approach in determining the environmental flows. While our results thus suggest that streamflow and EF may not be the only determinant of freshwater biodiversity at large scales, they do not preclude the existence of relationships at smaller scales or with more holistic EF methods (e.g., including water temperature, water quality, intermittency, connectivity, etc.) or with other biodiversity data or metrics.</p

Suppression of Phase Separation in LiFePO4 Nanoparticles During Battery Discharge

Using a novel electrochemical phase-field model, we question the common belief that LixFePO4 nanoparticles separate into Li-rich and Li-poor phases during battery discharge. For small currents, spinodal decomposition or nucleation leads to moving phase boundaries. Above a critical current density (in the Tafel regime), the spinodal disappears, and particles fill homogeneously, which may explain the superior rate capability and long cycle life of nano-LiFePO4 cathodes.Comment: 27 pages, 8 figure

Modern microwave methods in solid state inorganic materials chemistry: from fundamentals to manufacturing

No abstract available