Establishment and development of Tabebuia rosea (Bignoniaceae) seedlings in a semideciduous tropical forest under management, Pacific coast of Mexico [Establecimiento y desarrollo de plántulas de Tabebuia rosea (Bignoniaceae) en una selva subcaducifolia manejada de la costa Pacáfica de México]

We evaluated the effect of soil "scarification" and vegetation clearing treatments on the natural regeneration and initial development of Tabebuia rosea (Bertold) DC. seedlings in a moderate sized semideciduous tropical forest subjected to wood harvesting on the coast of Jalisco, Mexico. The treatments were applied under "seed" trees, and the number of germinated seedlings and their development were evaluated for nine months. Soil "scarification" promoted seed germination and initial seedling development, while the control of the competing vegetation increased the seedling growth and reduced their mortality. These results should be taken into account for the natural regeneration of this species, after clearing, to improve wood production, and should be incorporated into the silvicultural techniques currently developed in the region

Establishment and development of Tabebuia rosea (Bignoniaceae) seedlings in a semideciduous tropical forest under management, Pacific coast of Mexico [Establecimiento y desarrollo de plántulas de Tabebuia rosea (Bignoniaceae) en una selva subcaducifolia manejada de la costa Pacífica de México]

We evaluated the effect of soil "scarification" and vegetation clearing treatments on the natural regeneration and initial development of Tabebuia rosea (Bertold) DC. seedlings in a moderate sized semideciduous tropical forest subjected to wood harvesting on the coast of Jalisco, Mexico. The treatments were applied under "seed" trees, and the number of germinated seedlings and their development were evaluated for nine months. Soil "scarification" promoted seed germination and initial seedling development, while the control of the competing vegetation increased the seedling growth and reduced their mortality. These results should be taken into account for the natural regeneration of this species, after clearing, to improve wood production, and should be incorporated into the silvicultural techniques currently developed in the region

Study protocol for a randomized clinical trial to assess 7 versus 14-days of treatment for Pseudomonas aeruginosa bloodstream infections (SHORTEN-2 trial)

Background Research priorities in Antimicrobial Stewardship (AMS) have rapidly evolved in the last decade. The need for a more efficient use of antimicrobials have fueled plenty of studies to define the optimal duration for antibiotic treatments, and yet, there still are large areas of uncertainty in common clinical scenarios. Pseudomonas aeruginosa has been pointed as a priority for clinical research, but it has been unattended by most randomized trials tackling the effectiveness of short treatments. The study protocol of the SHORTEN-2 trial is presented as a practical example of new ways to approach common obstacles for clinical research in AMS. Objective To determine whether a 7-day course of antibiotics is superior to 14-day schemes for treating bloodstream infections by P. aeruginosa (BSI-PA). Methods A superiority, open-label, randomized controlled trial will be performed across 30 Spanish hospitals. Adult patients with uncomplicated BSI-PA will be randomized to receive a 7 versus 14-day course of any active antibiotic. The primary endpoint will be the probability for the 7-day group of achieving better outcomes than the control group, assessing altogether clinical effectiveness, severe adverse events, and antibiotic exposure through a DOOR/RADAR analysis. Main secondary endpoints include treatment failure, BSI-PA relapses, and mortality. A superiority design was set for the primary endpoint and non-inferiority for treatment failure, resulting in a sample size of 304 patients. Conclusions SHORTEN-2 trial aligns with some of the priorities for clinical research in AMS. The implementation of several methodological innovations allowed overcoming common obstacles, like feasible sample sizes or measuring the clinical impact and unintended effects