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Thesis (Ed.M.)--Boston Universit

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Field science in the Railroad Era: the tools of knowledge empire in the American West, 1869-1916 Pesquisas de campo na era das ferrovias: os instrumentos do império dos conhecimentos no Oeste dos Estados Unidos, 1869-1916

Focusing on the field sciences during the late nineteenth and early twentieth centuries, this paper analyzes how railroads served as tools of knowledge empire in the American West. The political economy of this region, shaped by the rise of Populism and capitalist development with federal and state government support, provided the context for cooperation between field scientists and railroad companies. Early on, the displacement of American Indians and their concentration on reservations was intertwined with the research of the Bureau of Ethnology under John Wesley Powell. Later, railroad companies became important patrons of field research, primarily through their provision of free or reduced-fare passes for travel. This research ranged from state universities undertaking research in horticulture and irrigation engineering to metropolitan natural history museums whose field work in paleontology had cultural or symbolic value.<br>Ao analisar pesquisas de campo realizadas no final do século XIX e início do XX, o artigo mostra como as estradas de ferro foram instrumentos do império dos conhecimentos no Oeste dos Estados Unidos. A economia política da região foi modelada pela ascensão do populismo e pelo desenvolvimento do capitalismo com o apoio dos governos estaduais e federal. Criaram-se assim as condições para a cooperação entre cientistas e companhias ferroviárias. Num primeiro momento, o deslocamento dos índios e sua concentração em reservas estiveram relacionados às pesquisas do Escritório de Etnologia, então dirigido por John Wesley Powell. As companhias ferroviárias tornaram-se importantes patrocinadoras de pesquisas de campo fornecendo passagens gratuitas ou a custos reduzidos para as viagens dos cientistas, desde aqueles ligados a universidades públicas que promoviam estudos sobre horticultura e engenharia da irrigação, até museus metropolitanos de história natural, cujos trabalhos de campo em paleontologia tinham valor simbólico ou cultural