Longitudinal trends in prostate cancer incidence, mortality, and survival of patients from two Shanghai city districts: a retrospective population-based cohort study, 2000-2009.

BackgroundProstate cancer is the fifth most common cancer affecting men of all ages in China, but robust surveillance data on its occurrence and outcome is lacking. The specific objective of this retrospective study was to analyze the longitudinal trends of prostate cancer incidence, mortality, and survival in Shanghai from 2000 to 2009.MethodsA retrospective population-based cohort study was performed using data from a central district (Putuo) and a suburban district (Jiading) of Shanghai. Records of all prostate cancer cases reported to the Shanghai Cancer Registry from 2000 to 2009 for the two districts were reviewed. Prostate cancer outcomes were ascertained by matching cases with individual mortality data (up to 2010) from the National Death Register. The Cox proportional hazards model was used to analyze factors associated with prostate cancer survival.ResultsA total of 1022 prostate cancer cases were diagnosed from 2000 to 2009. The average age of patients was 75 years. A rapid increase in incidence occurred during the study period. Compared with the year 2000, 2009 incidence was 3.28 times higher in Putuo and 5.33 times higher in Jiading. Prostate cancer mortality declined from 4.45 per 105 individuals per year in 2000 to 1.94 per 105 in 2009 in Putuo and from 5.45 per 105 to 3.5 per 105 in Jiading during the same period. One-year and 5-year prostate cancer survival rates were 95% and 56% in Putuo, and 88% and 51% in Jiading, respectively. Staging of disease, Karnofsky Performance Scale Index, and selection of chemotherapy were three independent factors influencing the survival of prostate cancer patients.ConclusionsThe prostate cancer incidence increased rapidly from 2000 to 2009, and prostate cancer survival rates decreased in urban and suburban Chinese populations. Early detection and prompt prostate cancer treatment is important for improving health and for increasing survival rates of the Shanghai male population

ZOOpt: Toolbox for Derivative-Free Optimization

Recent advances of derivative-free optimization allow efficient approximating the global optimal solutions of sophisticated functions, such as functions with many local optima, non-differentiable and non-continuous functions. This article describes the ZOOpt (https://github.com/eyounx/ZOOpt) toolbox that provides efficient derivative-free solvers and are designed easy to use. ZOOpt provides a Python package for single-thread optimization, and a light-weighted distributed version with the help of the Julia language for Python described functions. ZOOpt toolbox particularly focuses on optimization problems in machine learning, addressing high-dimensional, noisy, and large-scale problems. The toolbox is being maintained toward ready-to-use tool in real-world machine learning tasks

Deformable Convolutional Networks

Convolutional neural networks (CNNs) are inherently limited to model geometric transformations due to the fixed geometric structures in its building modules. In this work, we introduce two new modules to enhance the transformation modeling capacity of CNNs, namely, deformable convolution and deformable RoI pooling. Both are based on the idea of augmenting the spatial sampling locations in the modules with additional offsets and learning the offsets from target tasks, without additional supervision. The new modules can readily replace their plain counterparts in existing CNNs and can be easily trained end-to-end by standard back-propagation, giving rise to deformable convolutional networks. Extensive experiments validate the effectiveness of our approach on sophisticated vision tasks of object detection and semantic segmentation. The code would be released

Hyperbolic Circle Packings and Total Geodesic Curvatures on Surfaces with Boundary

This paper investigates a generalized hyperbolic circle packing (including circles, horocycles or hypercycles) with respect to the total geodesic curvatures on the surface with boundary. We mainly focus on the existence and rigidity of circle packing whose contact graph is the $1$-skeleton of a finite polygonal cellular decomposition, which is analogous to the construction of Bobenko and Springborn [4]. Motivated by Colin de Verdi\`ere's method [6], we introduce the variational principle for generalized hyperbolic circle packings on polygons. By analyzing limit behaviours of generalized circle packings on polygons, we give an existence and rigidity for the generalized hyperbolic circle packing with conical singularities regarding the total geodesic curvature on each vertex of the contact graph. As a consequence, we introduce the combinatoral Ricci flow to find a desired circle packing with a prescribed total geodesic curvature on each vertex of the contact graph.Comment: 26 pages, 7 figure

Fractional quantum Hall interface induced by geometric singularity

The geometric response of quantum Hall liquids is an important aspect to understand their topological characteristics in addition to the electromagnetic response. According to the Wen-Zee theory, the topological spin is coupled to the curvature of the space in which the electrons reside. The presence of conical geometry provides a local isolated geometric singularity, making it suitable for exploring the geometric response. In the context of two-dimensional electrons in a perpendicular magnetic field, each Landau orbit occupies the same area. The cone geometry naturally provides a structure in which the distances between two adjacent orbits gradually change and can be easily adjusted by altering the tip angle. The presence of a cone tip introduces a geometric singularity that affects the electron density and interacts with the motion of electrons, which has been extensively studied. Furthermore, this type of geometry can automatically create a smooth interface or crossover between the crystalline charge-density-wave state and the liquid-like fractional quantum Hall state. In this work, the properties of this interface are studied from multiple perspectives, shedding light on the behavior of quantum Hall liquids in such geometric configurations

Daisy: Data analysis integrated software system for X-ray experiments

Daisy (Data Analysis Integrated Software System) has been designed for the analysis and visualization of the X-ray experiments. To address an extensive range of Chinese radiation facilities community's requirements from purely algorithmic problems to scientific computing infrastructure, Daisy sets up a cloud-native platform to support on-site data analysis services with fast feedback and interaction. The plugs-in based application is convenient to process the expected high throughput data flow in parallel at next-generation facilities such as the High Energy Photon Source (HEPS). The objectives, functionality and architecture of Daisy are described in this article