Ecological Crisis, or “Intersex Panic,” as Answer of the Real?

Drawing upon Cal’s eventual metamorphosis into “The [white] Man” in Middlesex, and an examination of the Real of ecological crisis, Hsu explores the intersection of environmental racism, climate change denial, and intersex discrimination in order to advocate for a renewed awareness of ecological interdependency and the need for self-determination of people of colour in ecological and environmental justice discourses

A Comparison of Illicit and Licit Substances as Primary Substances of Abuse at Admission to Substance Abuse Treatment Centers in Georgia, 2009-2012

Objectives. We examined the patterns of association that exist between socio-demographic variables and the risk of having an illicit substance as a primary substance of abuse. Methods. A cross-sectional study on secondary data from the Treatment Episode Data Set (TEDS) observed socio-demographic patterns among those over 18 years old admitted for substance abuse treatment in Georgia during 2009-2012. Results. The distribution of licit substance users and illicit substance users was significantly different along all socio-demographic variables. Risk of admission for an illicit substance was highest among those unemployed, living independently, and who did not graduate from high school. Conclusion. The findings of this study show that admission for treatment of an illicit substance are congruent with what was previously known about groups with the highest risk. However other findings about gender differences, age, and independent living promote changes in prevention and directions for further research

Supply chain optimization in a retail environment

Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering; in conjunction with the Leaders for Manufacturing Program at MIT, 2003.Includes bibliographical references (p. 53).by Stephanie K. Hsu.S.M.M.B.A

System FC with Explicit Kind Equality

System FC, the core language of the Glasgow Haskell Compiler, is an explicitly-typed variant of System F with first-class type equality proofs called coercions. This extensible proof system forms the foundation for type system extensions such as type families (type- level functions) and Generalized Algebraic Datatypes (GADTs). Such features, in conjunction with kind polymorphism and datatype promotion, support expressive compile-time reasoning. However, the core language lacks explicit kind equality proofs. As a result, type-level computation does not have access to kind- level functions or promoted GADTs, the type-level analogues to expression-level features that have been so useful. In this paper, we eliminate such discrepancies by introducing kind equalities to System FC. Our approach is based on dependent type systems with heterogeneous equality and the “Type-in-Type” axiom, yet it preserves the metatheoretic properties of FC. In particular, type checking is simple, decidable and syntax directed. We prove the preservation and progress theorems for the extended language

System FC with Explicit Kind Equality (extended version)

System FC, the core language of the Glasgow Haskell Compiler, is an explicitly-typed variant of System F with first-class type equality proofs called coercions. This extensible proof system forms the foundation for type system extensions such as type families (type- level functions) and Generalized Algebraic Datatypes (GADTs). Such features, in conjunction with kind polymorphism and datatype promotion, support expressive compile-time reasoning. However, the core language lacks explicit kind equality proofs. As a result, type-level computation does not have access to kind- level functions or promoted GADTs, the type-level analogues to expression-level features that have been so useful. In this paper, we eliminate such discrepancies by introducing kind equalities to System FC. Our approach is based on dependent type systems with heterogeneous equality and the “Type-in-Type” axiom, yet it preserves the metatheoretic properties of FC. In particular, type checking is simple, decidable and syntax directed. We prove the preservation and progress theorems for the extended language

Association of professional identity, gender, team understanding, anxiety and workplace learning alignment with burnout in junior doctors: a longitudinal cohort study

Objectives To examine how burnout across medical student to junior doctor transition relates to: measures of professional identity, team understanding, anxiety, gender, age and workplace learning (assistantship) alignment to first post. Design A longitudinal 1-year cohort design. Two groups of final-year medical students: (1) those undertaking end-of-year assistantships aligned in location and specialty with their first post and (2) those undertaking assistantships non-aligned. An online questionnaire included: Professional Identity Scale, Team Understanding Scale, modified Hamilton Anxiety Rating Scale and modified Copenhagen Burnout Inventory. Data were collected on four occasions: (T1) prior to graduation; (T2) 1 month post-transition; (T3) 6 months post-transition and (T4) 10 months post-transition. Questionnaires were analysed individually and using linear mixed-effect models. Setting Medical schools and postgraduate training in one UK country. Participants All aligned assistantship (n=182) and non-aligned assistantship students (n=319) were contacted; n=281 (56%) responded: 68% (n=183) females, 73% (n=206) 22–30 years, 46% aligned (n=129). Completion rates: aligned 72% (93/129) and non-aligned 64% (98/152). Results Analyses of individual scales revealed that self-reported anxiety, professional identity and patient-related burnout were stable, while team understanding, personal and work-related burnout increased, all irrespective of alignment. Three linear mixed-effect models (personal, patient-related and work-related burnout as outcome measures; age and gender as confounding variables) found that males self-reported significantly lower personal, but higher patient-related burnout, than females. Age and team understanding had no effect. Anxiety was significantly positively related and professional identity was significantly negatively related to burnout. Participants experiencing non-aligned assistantships reported higher personal and work-related burnout over time. Conclusions Implications for practice include medical schools’ consideration of an end-of-year workplace alignment with first-post before graduation or an extended shadowing period immediately postgraduation. How best to support undergraduate students’ early professional identity development should be examined. Support systems should be in place across the transition for individuals with a predisposition for anxiety

Revealing the production of performance in the Hawaiian Islands

Thesis (M. Arch.)--Massachusetts Institute of Technology, Dept. of Architecture, 2008.Includes bibliographical references (p. 91).Harbors throughout the Hawaiian Islands serve as the dating a growing commercial cruise ship industry, foreign activity. They are also increasingly sites of controversy structures restrict local access and use of harbor areas man scale. This thesis proposes a platform for performance that ... floating and traveling between the four major Hawaiian Islands within multiple sites, accommodating public frames industrial harbor activity rather than staging no Hawaii's (neo)-colonial grand narrative as a sexualized as an instrument to reflect the relationship between pr den mechanics of calculated and market-oriented production and the outward appearance of contrived reality. Relationships between audience, stage, and performer shift to reveal the production of the performance, and reinsert the audience as a part of the theatrical experience. The architecture is a stage set for the performance that is not limited to a fixed stage but happens throughout the venue as localized spectacle.by Stephanie Hsu.M.Arch

Alpha-crystallin mutations alter lens metabolites in mouse models of human cataracts

Cataracts are a major cause of blindness worldwide and commonly occur in individuals over 70 years old. Cataracts can also appear earlier in life due to genetic mutations. The lens proteins, αA- and αB-crystallins, are chaperone proteins that have important roles maintaining protein solubility to prevent cataract formation. Mutations in the CRYAA and CRYAB crystallin genes are associated with autosomal dominant early onset human cataracts. Although studies about the proteomic and genomic changes that occur in cataracts have been reported, metabolomics studies are very limited. Here, we directly investigated cataract metabolism using gas-chromatography-mass spectrometry (GC-MS) to analyze the metabolites in adult Cryaa-R49C and Cryab-R120G knock-in mouse lenses. The most abundant metabolites were myo-inositol, L-(+)-lactic acid, cholesterol, phosphate, glycerol phosphate, palmitic and 9-octadecenoic acids, α-D-mannopyranose, and β-D-glucopyranose. Cryaa-R49C knock-in mouse lenses had a significant decrease in the number of sugars and minor sterols, which occurred in concert with an increase in lactic acid. Cholesterol composition was unchanged. In contrast, Cryab-R120G knock-in lenses exhibited increased total amino acid content including valine, alanine, serine, leucine, isoleucine, glycine, and aspartic acid. Minor sterols, including cholest-7-en-3-ol and glycerol phosphate were decreased. These studies indicate that lenses from Cryaa-R49C and Cryab-R120G knock-in mice, which are models for human cataracts, have unique amino acid and metabolite profiles

Examining the Course of Transitions from Hospital to Home-based Palliative Care: A Mixed Methods Study

Background: Hospital-to-home transitions in palliative care are fraught with challenges. To assess transitions researchers have used patient reported outcome measures and qualitative data to give unique insights into a phenomenon. Few measures examine care setting transitions in palliative care, yet domains identified in other populations are likely relevant for patients receiving palliative care. Aim: Gain insight into how patients experience three domains, discharge readiness, transition quality, and discharge-coping, during hospital-to-home transitions. Design: Longitudinal, convergent parallel mixed methods study design with two data collection visits: in-hospital before and 3–4 weeks after discharge. Participants completed scales assessing discharge readiness, transition quality, and post discharge-coping. A qualitative interview was conducted at both visits. Data were analyzed separately and integrated using a merged transformative methodology, allowing us to compare and contrast the data. Setting and participants: Study was set in two tertiary hospitals in Toronto, Canada. Adult inpatients (n = 25) and their caregivers (n = 14) were eligible if they received a palliative care consultation and transitioned to home-based palliative care. Results: Results were organized aligning with the scales; finding low discharge readiness (5.8; IQR: 1.9), moderate transition quality (66.7; IQR: 33.33), and poor discharge-coping (5.0; IQR: 2.6), respectively. Positive transitions involved feeling well supported, managing medications, feeling well, and having healthcare needs met. Challenges in transitions were feeling unwell, confusion over medications, unclear healthcare responsibilities, and emotional distress. Conclusions: We identified aspects of these three domains that may be targeted to improve transitions through intervention development. Identified discrepancies between the data types should be considered for future research exploration