Hemodynamics in Ruptured Intracranial Aneurysms

Incidental detection of unruptured intracranial aneurysms (UIA) has increased in the recent years. There is a need in the clinical community to identify those that are prone to rupture and would require preventive treatment. Hemodynamics in cerebral blood vessels plays a key role in the lifetime cycle of intracranial aneurysms (IA). Understanding their initiation, growth, and rupture or stabilization may identify those hemodynamic features that lead to aneurysm instability and rupture. Modeling hemodynamics using computational fluid dynamics (CFD) could aid in understanding the processes in the development of IA. The neurosurgical approach during operation of IA allows direct visualization of the aneurysm sac and its sampling in many cases. Detailed analysis of the quality of the aneurysm wall under the microscope, together with histological assessment of the aneurysm wall and CFD modeling, can help in building complex knowledge on the relationship between the biology of the wall and hemodynamics. Detailed CFD analysis of the rupture point can further strengthen the association between hemodynamics and rupture. In this chapter we summarize current knowledge on CFD and intracranial aneurysms

Characterization of solid-fluid mixtures

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Includes bibliographical references (leaves 59-65).Issued also on microfiche from Lange Micrographics.In this work we develop and investigate a mathematical model for the description of the mechanical behavior of soft, hydrated tissues with significant perfusion. We set up and derive the mathematical description and balance laws using the continuum mixture theory as the theoretical framework. The constitutive relations suitable to describe perfumed soft tissue and appropriate bounder conditions are discussed in terms of its possible determination from experimental data. We solve illustrative steady, one and two dimensional problems of disunion through snidely deformed slab, and develop and implement appropriate numerical schemes. The main focus is on developing an algorithm based on finite elements for finding approximate solution to the continuous, nonlinear, steady, two dimensional problem

Flux analysis by modified osmotic-pressure model for laminar ultrafiltration of macromolecular solutions

[[abstract]]A method for predicting permeate fluxes in laminar ultrafiltration of macromolecular solutions was proposed. The method is based on a modified osmotic pressure model with the mass transfer coefficient estimated from the Leveque solution and the diffusion coefficient evaluated at the mean concentration of the concentration polarization layer. The validity of the method was tested by comparing predictions with experiments.[[notice]]補正完畢[[journaltype]]國外[[countrycodes]]GB

Tidal dissipation in Enceladus' uneven, fractured ice shell

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Long-term stability of Enceladus’ uneven ice shell

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A benchmark problem to evaluate implementational issues for three-dimensional flows of incompressible fluids subject to slip boundary conditions

International audienceWe consider flows of an incompressible Navier-Stokes fluid in a tubular domain with Navier's slip boundary condition imposed on the impermeable wall. We focus on several implementational issues associated with this type of boundary conditions within the framework of the standard Taylor-Hood mixed finite element method and present the computational results for flows in a tubular domain of finite length with one inlet and one outlet. In particular, we present the details regarding variants of the Nitsche method concerning the incorporation of the impermeability condition on the wall. We also find that the manner in which the normal to the boundary is numerically implemented influences the nature of the computational results. As a benchmark, we set up steady flows in a tube of finite length and compare the computational results with the analytical solutions. Finally, we identify various quantities of interest, such as the dissipation, wall shear stress, vorticity, pressure drop, and provide their precise mathematical definitions. We document how well these quantities are computationally approximated in the case of the benchmark. Although the geometry of the benchmark is simple, the correct computational results require careful selection of numerical methods and surprisingly non-trivial computational resources. Our goal is to test, using the setting with a known analytical solution, a robust computational tool that would be suitable for computations on real complex geometries that have relevance to problems in engineering and medicine. The model parameters in our computations are chosen based on flows in large arteries

Runaway electron diagnostics for the COMPASS tokamak using EC emission

An electron cyclotron emission (ECE) diagnostic of suprathermal electrons was utilised for runaway electron (RE) experiments purposes in the COMPASS tokamak. Our vertical ECE (V-ECE) system consists of a 16-channel heterodyne radiometer and an E-band horn antenna with a 76.5-88 GHz frequency range front-end. Simulations used for the design of the diagnostic showed a possibility of detecting the emission of low-energy (50-140 keV) runaway electrons. We realized measurements with both extraordinary (X-) and ordinary (O-) mode linear polarizations. The amplitudes of the X-mode and O-mode signals are similar, which can be explained by depolarised reflected radiation. V-ECE measurements in low-density flattop discharges and in discharges with massive gas injections of high-Z elements show correlations with other RE diagnostics. Our results are in the agreement with the principles of the primary runaway generation mechanisms