11 research outputs found
Mitochondrial function as a determinant of life span
Average human life expectancy has progressively increased over many decades largely due to improvements in nutrition, vaccination, antimicrobial agents, and effective treatment/prevention of cardiovascular disease, cancer, etc. Maximal life span, in contrast, has changed very little. Caloric restriction (CR) increases maximal life span in many species, in concert with improvements in mitochondrial function. These effects have yet to be demonstrated in humans, and the duration and level of CR required to extend life span in animals is not realistic in humans. Physical activity (voluntary exercise) continues to hold much promise for increasing healthy life expectancy in humans, but remains to show any impact to increase maximal life span. However, longevity in Caenorhabditis elegans is related to activity levels, possibly through maintenance of mitochondrial function throughout the life span. In humans, we reported a progressive decline in muscle mitochondrial DNA abundance and protein synthesis with age. Other investigators also noted age-related declines in muscle mitochondrial function, which are related to peak oxygen uptake. Long-term aerobic exercise largely prevented age-related declines in mitochondrial DNA abundance and function in humans and may increase spontaneous activity levels in mice. Notwithstanding, the impact of aerobic exercise and activity levels on maximal life span is uncertain. It is proposed that age-related declines in mitochondrial content and function not only affect physical function, but also play a major role in regulation of life span. Regular aerobic exercise and prevention of adiposity by healthy diet may increase healthy life expectancy and prolong life span through beneficial effects at the level of the mitochondrion
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Higher Fusion Power Gain with Current and Pressure Profile Control in Strongly Shaped DIII-D Tokamak Plasmas.
Fusion power has been increased by a factor of 3 in DIII-D by tailoring the pressure profile to avoid the kink instability in H-mode plasmas. The resulting plasmas are found to have neoclassical ion confinement. This reduction in transport losses in beam-heated plasmas with negative central shear is correlated with a dramatic reduction in density fluctuations. Improved magnetohydrodynamic stability is achieved by controlling the plasma pressure profile width. In deuterium plasmas the highest gain Q (the ratio of fusion power to input power), was 0.0015, corresponding to an equivalent Q of 0.32 in a deuterium-tritium plasma. © 1996 The American Physical Society
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Higher fusion power gain with profile control in DIII-D tokamak plasmas
Strong shaping, favourable for stability and improved energy confinement, together with a significant expansion of the central region of improved confinement in negative central magnetic shear target plasmas, increased the maximum fusion power produced in DIII-D by a factor of 3. Using deuterium plasmas, the highest fusion power gain, the ratio of fusion power to input power, Q, was 0.0015, corresponding to an equivalent Q of 0.32 in a deuterium-tritium plasma, which is similar to values achieved in tokamaks of larger size and magnetic field. A simple transformation relating Q to the stability parameters is presented
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Higher fusion power gain with profile control in DIII-D tokamak plasmas
Strong shaping, favourable for stability and improved energy confinement, together with a significant expansion of the central region of improved confinement in negative central magnetic shear target plasmas, increased the maximum fusion power produced in DIII-D by a factor of 3. Using deuterium plasmas, the highest fusion power gain, the ratio of fusion power to input power, Q, was 0.0015, corresponding to an equivalent Q of 0.32 in a deuterium-tritium plasma, which is similar to values achieved in tokamaks of larger size and magnetic field. A simple transformation relating Q to the stability parameters is presented
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Local analysis of confinement and transport in neutral beam heated DIII-D discharges with negative magnetic shear
Chemical Composition of Polymer Surfaces Imaged by Atomic Force Microscopyand Complementary Approaches
Unfortunately, the editor of this article Hans-Henning Kausch was published as author in the XML-version