Commercial Cargo Derivative Study of the Advanced Hybrid Wing Body Configuration with Over-Wing Engine Nacelles

LM has leveraged our partnership with the Air Force Research Laboratory (AFRL) and NASA on the advanced hybrid wing body (HWB) concept to develop a commercial freighter which addresses the NASA Advanced Air Transport Technology (AATT) Project goals for improved efficiency beyond 2025. The current Air Force Research Laboratory (AFRL) Revolutionary Configurations for Energy Efficiency (RCEE) program established the HWB configuration and technologies needed for military transports to achieve aerodynamic and fuel efficiencies well beyond the commercial industry's most modern designs. This study builds upon that effort to develop a baseline commercial cargo aircraft and two HWB derivative commercial cargo aircraft to quanitify the benefit of the HWB and establish a technology roadmap for further development

The 2010 AOP Workshop Summary Report

The rationale behind the current workshop, which was hosted by Biospherical Instruments Inc. (BSI), was to update the community and get community input with respect to the following: topics not addressed during the first workshop, specifically the processing of above-water apparent optical property (AOP data) within the Processing of Radiometric Observations of Seawater using Information Technologies (PROSIT) architecture; PROSIT data processing issues that have developed or tasks that have been completed, since the first workshop; and NASA instrumentation developments, both above- and in-water, that are relevant to both workshops and next generation mission planning. The workshop emphasized presentations on new AOP instrumentation, desired and required features for processing above-water measurements of the AOPs of seawater, working group discussions, and a community update for the in-water data processing already present in PROSIT. The six working groups were organized as follows: a) data ingest and data products; b) required and desired features for optically shallow and optically deep waters; c) contamination rejection (clouds), corrections, and data filtering; d) sun photometry and polarimetry; e) instrumentation networks; and f) hyperspectral versus fixed-wavelength sensors. The instrumentation networks working group was intended to provide more detailed information about desired and required features of autonomous sampling systems. Plenary discussions produced a number of recommendations for evolving and documenting PROSIT

Assessment of cefazolin and cefuroxime tissue penetration by using a continuous intravenous infusion.

A continuous intravenous infusion was used to assess the tissue penetration of cefazolin (14 subjects) and cefuroxime (15 subjects) in orthopedic surgery patients. Subjects were randomly assigned to receive a continuous intravenous infusion of cefazolin (mean, 178.6 mg/h) orcefuroxime (mean, 330.0 mg/h) at a rate estimated to achieve a target steady-state total concentration of 50 micrograms/ml in serum. The infusion was initiated 12 to 14 h before surgery, and blood and muscle tissue samples were collected intraoperatively at the times of incision and wound closure. Although there was a significant difference between the free concentrations ofcefazolin (at incision, 9.3 micrograms/ml; at closure, 9.2 micrograms/ml) and cefuroxime in serum (at incision, 26.9 micrograms/ml; at closure, 31.8 micrograms/ml), there was no difference in the total concentrations in muscle at either surgical incision (cefazolin, 6.1 micrograms/g; cefuroxime, 5.6 micrograms/g) or wound closure (cefazolin, 7.7 micrograms/g; cefuroxime, 7.4 micrograms/g). There was a significant correlation between the pooled free serum and total muscle concentrations for cefazolin (P = 0.001); however, there was no correlation between these variables with the pooledcefuroxime data (P = 0.403). These findings indicate that the free drug concentration in serum alone is not consistently predictive of the total concentration of cephalosporin in muscle

Advances in Measuring the Apparent Optical Properties (AOPs) of Optically Complex Waters

This report documents new technology used to measure the apparent optical properties (AOPs) of optically complex waters. The principal objective is to be prepared for the launch of next-generation ocean color satellites with the most capable commercial off-the-shelf (COTS) instrumentation. An enhanced COTS radiometer was the starting point for designing and testing the new sensors. The follow-on steps were to apply the lessons learned towards a new in-water profiler based on a kite-shaped backplane for mounting the light sensors. The next level of sophistication involved evaluating new radiometers emerging from a development activity based on so-called microradiometers. The exploitation of microradiometers resulted in an in-water profiling system, which includes a sensor networking capability to control ancillary sensors like a shadowband or global positioning system (GPS) device. A principal advantage of microradiometers is their flexibility in producing, interconnecting, and maintaining instruments. The full problem set for collecting sea-truth data--whether in coastal waters or the open ocean-- involves other aspects of data collection that were improved for instruments measuring both AOPs and inherent optical properties (IOPs), if the uncertainty budget is to be minimized. New capabilities associated with deploying solar references were developed as well as a compact solution for recovering in-water instrument systems from small boats

SeaWiFS technical report series. Volume 32: Level-3 SeaWiFS data products. Spatial and temporal binning algorithms

The level-3 data products from the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) are statistical data sets derived from level-2 data. Each data set will be based on a fixed global grid of equal-area bins that are approximately 9 x 9 sq km. Statistics available for each bin include the sum and sum of squares of the natural logarithm of derived level-2 geophysical variables where sums are accumulated over a binning period. Operationally, products with binning periods of 1 day, 8 days, 1 month, and 1 year will be produced and archived. From these accumulated values and for each bin, estimates of the mean, standard deviation, median, and mode may be derived for each geophysical variable. This report contains two major parts: the first (Section 2) is intended as a users' guide for level-3 SeaWiFS data products. It contains an overview of level-0 to level-3 data processing, a discussion of important statistical considerations when using level-3 data, and details of how to use the level-3 data. The second part (Section 3) presents a comparative statistical study of several binning algorithms based on CZCS and moored fluorometer data. The operational binning algorithms were selected based on the results of this study

Optical Sensors for Planetary Radiant Energy (OSPREy): Calibration and Validation of Current and Next-Generation NASA Missions

A principal objective of the Optical Sensors for Planetary Radiance Energy (OSPREy) activity is to establish an above-water radiometer system as a lower-cost alternative to existing in-water systems for the collection of ground-truth observations. The goal is to be able to make high-quality measurements satisfying the accuracy requirements for the vicarious calibration and algorithm validation of next-generation satellites that make ocean color and atmospheric measurements. This means the measurements will have a documented uncertainty satisfying the established performance metrics for producing climate-quality data records. The OSPREy approach is based on enhancing commercial-off-the-shelf fixed-wavelength and hyperspectral sensors to create hybridspectral instruments with an improved accuracy and spectral resolution, as well as a dynamic range permitting sea, Sun, sky, and Moon observations. Greater spectral diversity in the ultraviolet (UV) will be exploited to separate the living and nonliving components of marine ecosystems; UV bands will also be used to flag and improve atmospheric correction algorithms in the presence of absorbing aerosols. The short-wave infrared (SWIR) is expected to improve atmospheric correction, because the ocean is radiometrically blacker at these wavelengths. This report describes the development of the sensors, including unique capabilities like three-axis polarimetry; the documented uncertainty will be presented in a subsequent report

Sedentary behavior and subclinical atherosclerosis in African Americans: cross-sectional analysis of the Jackson heart study

BACKGROUND: Previous studies have reported conflicting results as to whether an association exists between sedentary time and cardiovascular disease (CVD) risk among African Americans. These studies, however, were limited by lack of consideration of sedentary behavior in leisure versus non-leisure settings. To elucidate this relation, we investigated the associations of television (TV) viewing time and occupational sitting with carotid intima-media thickness (CIMT), a subclinical atherosclerosis measure, in a community-based sample of African Americans. METHODS: We studied 3410 participants from the Jackson Heart Study, a single-site, community-based study of African Americans residing in Jackson, MS. CIMT was assessed by ultrasonography and represented mean far-wall thickness across right and left sides of the common carotid artery. TV viewing time, a measure of leisure sedentary behavior, and occupational sitting, a measure of non-leisure sedentary behavior, were assessed by questionnaire. RESULTS: In a multivariable regression model that included physical activity and CVD risk factors, longer TV viewing time (2-4 h/day and >4 h/day) was associated with greater CIMT (adjusted mean ± SE difference from referent [4 h/day; P-trend =0.001). In contrast, more frequent occupational sitting ('sometimes' and 'often/always') was associated with lower CIMT (adjusted mean ± SE difference from referent ['never/seldom']:-0.021 ± 0.009 mm for 'sometimes', and-0.018 ± 0.008 mm for 'often/always'; P-trend = 0.042). CONCLUSIONS: Longer TV viewing time was associated with greater CIMT, while occupational sitting was associated with lower CIMT. These findings suggest the role of sedentary behaviors in the pathogenesis of CVD among African Americans may vary by whether individuals engage in leisure versus non-leisure sedentary behaviors

A history of high-power laser research and development in the United Kingdom

The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years