ЭФФЕКТИВНОСТЬ РАННЕГО НАЧАЛА ПРИМЕНЕНИЯ БИВАЛИРУДИНА ВО ВРЕМЯ ТРАНСПОРТИРОВКИ БОЛЬНОГО В ЛЕЧЕБНОЕ УЧРЕЖДЕНИЕ ДЛЯ ВЫПОЛНЕНИЯ ПЕРВИЧНОГО ЧРЕСКОЖНОГО ВМЕШАТЕЛЬСТВА НА КОРОНАРНОЙ АРТЕРИИ: РЕЗУЛЬТАТЫ РАНДОМИЗИРОВАННОГО ИССЛЕДОВАНИЯ EUROMAX

Steg P.G., van ‘t Hof A., Hamm C.W., et al. Bivalirudin Startedduring Emergency Transportfor Primary PCI // N. Engl. J. Med. – 2013. Oct. 30. [Epub ahead of print].Источник: Steg P.G., van ‘t Hof A., Hamm C.W., et al. Bivalirudin Startedduring Emergency Transportfor Primary PCI // N. Engl. J. Med. – 2013. Oct. 30. [Epub ahead of print]

ЭФФЕКТИВНОСТЬ ПРИМЕНЕНИЯ ТИКАГРЕЛОРА НА ДОГОСПИТАЛЬНОМ ЭТАПЕ ЛЕЧЕНИЯ БОЛЬНЫХ ОСТРЫМ ИНФАРКТОМ МИОКАРДА С ПОДЪЕМОМ СЕГМЕНТА ST: РЕЗУЛЬТАТЫ РАНДОМИЗИРОВАННОГО ИССЛЕДОВАНИЯ ATLANTIC

Montalescot G., van ‘t Hof A.W., Lapostolle F., et al. Prehospital ticagrelor in ST-segment elevation myocardial infarction // N. Engl. J. Med. – 2014. – Vol. 371. – P. 1016–1027.Источник: Montalescot G., van ‘t Hof A.W., Lapostolle F., et al. Prehospital ticagrelor in ST-segment elevation myocardial infarction // N. Engl. J. Med. – 2014. – Vol. 371. – P. 1016–1027

Regsrealistiese evolusionere funksionalisme en ekstra-grondwetlike gronde vir die ontwikkeling van die gemeenregtelike deliktereg: 8 Kritiese ontleding van Heroldt v Wills 2013 2 SA 530 (GSJ)

In Heroldt v Wills is die gemenereg ontwikkel om aan te pas by die veranderende behoeftes van die samelewing. Meer spesifiek het die applikant in hierdie geval daarin geslaag om J interdik te verkry om die respondent te dwing om lasterlike materiaal aangaande die applikant vanaf Facebook te verwyder. In hierdie artikel word die uiteindelike beslissing ondersteun maar twee aspekte van die uitspraak word geproblematiseer. Eerstens problematiseer die skrywer die evolusionêre funksionalistiese benadering (soos wat die Amerikaanse regsrealiste die begrip beskryf) wat die hof hier toepas. Die uitspraak weerspieël J evolusionêre funksionalistiese benadering in die sin dat die hof van mening is dat die reg moet aanpas volgens die funksionele behoeftes van die samelewing om sekerheid en stabiliteit in die gees van tegnologiese veranderings, gemeenregtelike suiwerheid en regsdoeltreffendheid te verseker. Hierdie benadering word in hierdie artikel as problematies beskryf omdat dit die indruk skep dat die gemenereg op J onkontroversiële manier ontwikkel kan word in die rigting van J voorafbepaalde (deterministiese) evolusionêre baan waar politiese spannings tussen verskillende regsbelange geen rol speel nie. Tweedens problematiseer die skrywer die feit dat die Grondwet nie in hierdie uitspraak J substantiewe ideologiese rol in die gemeenregtelike ontwikkeling gespeel het nie. Om met hierdie probleem om te gaan word die vraag gestel of daar wel ekstra-grondwetlike gronde is waarvolgens die gemenereg ontwikkel kan word en, indien daar wel so J grond bestaan, wat die verhouding tussen daardie grond en die Grondwet is of behoort te wees. Hierdie vrae word beantwoord deur J historiografiese studie van die gronde vir die gemeenregtelike ontwikkeling in die Suid-Afrikaanse konteks. Daarna word J kritiese ontleding van Heroldt aangepak waarin daar geargumenteer word dat die beslissing in Heroldt J sterker fokus op die Grondwet moes gehad het sodat J kritiese benadering tot die ontwikkeling van die gemenereg toegepas kon word.http://www.lexisnexis.co.za2016-12-31am2016Private La

Pressure Insoles for Gait and Balance Estimation

Stroke leads to impairment in motor ability, gait, and balance, due to brain tissue damage [1]. Clinical therapy following stroke aims at improving mobility and functional capacity. However, there is lack of objective information about subject’s performance once they are transferred home [2]. A wearable, unobtrusive system is needed to describe and compare clinical capacity and performance in a home setting. ForceShoes™ (Xsens Technologies B.V., The Netherlands) had been developed to provide holistic information about subject’s gait and balance measures, such as Extrapolated Centre of Mass (XCoM) and Dynamic Stability Margin (DSM) [3], [4]. Using these measures, a clear distinction between the capacity and performance of the subject is seen. However, this system is obtrusive and requires a long time to set up. This project addresses the need for a wearable and minimal sensing system with an unobtrusive set up. Pressure insoles are lightweight and inconspicuous, and when coupled with an Inertial Measurement Unit (IMU), several gait and balance measures can be estimated. In this study, a 1-D pressure insole system (medilogic ® insoles, T&T medilogic Medizintechnik GmbH, Germany), coupled with IMUs, is investigated for objective quantification of gait and dynamic balance measures. Although, to obtain such measures, 3D forces and moments are required. Linear regression models were used to model 3D forces/moments from the 1D plantar pressures measured from pressure insoles. The predicted forces and moments were used for estimation of XCoM and DSM. These parameters were compared with the estimations done by the forces and moments from the Force Shoes™. The regression model is tested for different walking speeds. High correlation and low differences between the estimations from predicted and measured values show that pressure insoles can indeed be used as an wearable alternative. The results will also be used in designing a wearable in-shoe system that can be used in daily life monitoring for stroke subjects. The study is a part of project 7 of NeuroCIMT, funded by the Dutch National foundation STW. REFERENCES [1] S. F. Tyson, M. Hanley, J. Chillala, A. Selley, and R. C. Tallis, “Balance disability after stroke.,” Phys. Ther., vol. 86, no. 1, pp. 30–38, 2006. [2] B. Klaassen, B.-J. F. van Beijnum, M. Weusthof, D. Hof, F. B. van Meulen, Ed Droog, H. Luinge, L. Slot, A. Tognetti, F. Lorussi, R. Paradiso, J. Held, A. Luft, J. Reenalda, C. Nikamp, J. H. Buurke, H. J. Hermens, and P. H. Veltink, “A Full Body Sensing System for Monitoring Stroke Patients in a Home Environment,” Commun. Comput. Inf. Sci., vol. 511, pp. 378–393, 2016. [3] F. B. van Meulen, D. Weenk, E. H. F. van Asseldonk, H. M. Schepers, P. H. Veltink, and J. H. Buurke, “Analysis of Balance during Functional Walking in Stroke Survivors,” PLoS One, vol. 11, no. 11, p. e0166789, Nov. 2016. [4] F. B. van Meulen, D. Weenk, J. H. Buurke, B.-J. F. van Beijnum, and P. H. Veltink, “Ambulatory assessment of walking balance after stroke using instrumented shoes,” J. Neuroeng. Rehabil., vol. 13, no. 1, p. 48, 2016. [5] A. L. Hof, M. G. J. Gazendam, and W. E. Sinke, “The condition for dynamic stability,” J. Biomech., vol. 38, no. 1, pp. 1–8, 2005

Data-driven and Model-based Verification: a Bayesian Identification Approach

This work develops a measurement-driven and model-based formal verification approach, applicable to systems with partly unknown dynamics. We provide a principled method, grounded on reachability analysis and on Bayesian inference, to compute the confidence that a physical system driven by external inputs and accessed under noisy measurements, verifies a temporal logic property. A case study is discussed, where we investigate the bounded- and unbounded-time safety of a partly unknown linear time invariant system

Observer-based correct-by-design controller synthesis

Current state-of-the-art correct-by-design controllers are designed for full-state measurable systems. This work first extends the applicability of correct-by-design controllers to partially observable LTI systems. Leveraging 2nd order bounds we give a design method that has a quantifiable robustness to probabilistic disturbances on state transitions and on output measurements. In a case study from smart buildings we evaluate the new output-based correct-by-design controller on a physical system with limited sensor information

Gate Oxide Reliability and Deuterated CMOS Processing

In recent literature, a controversy has arisen over the question whether deuterium improves the stability of the MOS gate dielectric. It appears as if this controversy finds its origin in the different stages (e.g. oxidation or post metal anneal) deuterium is introduced in the CMOS process. This paper investigates this in detail. The obtained results show that the hot carrier degradation only benefits from an isotope effect when deuterium is introduced in the post metal anneal. At the same time, charge to breakdown for high quality oxides does not benefit from an isotope effect, regardless of the processing stage deuterium is introduced, or the gate oxide thickness used. This is verified on two different sets of wafers fabricated in two different laboratories

Prediction error identification of linear dynamic networks with rank-reduced noise

Dynamic networks are interconnected dynamic systems with measured node signals and dynamic modules reflecting the links between the nodes. We address the problem of \red{identifying a dynamic network with known topology, on the basis of measured signals}, for the situation of additive process noise on the node signals that is spatially correlated and that is allowed to have a spectral density that is singular. A prediction error approach is followed in which all node signals in the network are jointly predicted. The resulting joint-direct identification method, generalizes the classical direct method for closed-loop identification to handle situations of mutually correlated noise on inputs and outputs. When applied to general dynamic networks with rank-reduced noise, it appears that the natural identification criterion becomes a weighted LS criterion that is subject to a constraint. This constrained criterion is shown to lead to maximum likelihood estimates of the dynamic network and therefore to minimum variance properties, reaching the Cramer-Rao lower bound in the case of Gaussian noise.Comment: 17 pages, 5 figures, revision submitted for publication in Automatica, 4 April 201