Aberrant overexpression of an epithelial marker, 14-3-3σ, in a subset of hematological malignancies-4

<p><b>Copyright information:</b></p><p>Taken from "Aberrant overexpression of an epithelial marker, 14-3-3σ, in a subset of hematological malignancies"</p><p>http://www.biomedcentral.com/1471-2407/7/217</p><p>BMC Cancer 2007;7():217-217.</p><p>Published online 25 Nov 2007</p><p>PMCID:PMC2222637.</p><p></p>rkat cells (an open square). Dotted line denotes mean plus 2 SDs (2.17) of controls and a mean for each disease or cell line is shown as a horizontal bar. The vertical scales are different between the lower and higher levels. Open circles denote patients with p53 mutations identified by RT-PCR-SSCP analysis. Controls include 5 PBMNC, 3 BMMNC, 2 reactive lymph nodes; CML, 7 patients with blast crisis (BC) and 1 patient with chronic phase (CP) of chronic myeloid leukemia; AML, 12 patients with acute myeloid leukemia; ALL, 16 patients with acute lymphoid leukemia including 3 patients with Burkitt leukemia/lymphoma; ATL, 8 patients with adult T-cell leukemia/lymphoma (1 chronic, 1 acute, and 6 lymphoma variants); CLL, 5 patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and 3 patients with prolymphocytic leukemia; DLBCL, 27 patients with diffuse large B-cell lymphoma; FL, 29 patients with follicular lymphoma; other NHL, 4 patients with T-cell lymphoma, 2 patients with mantle cell lymphoma and 3 patients with unclassified lymphoma; PCD, 12 patients with plasma cell dyscrasias including 1 patient with plasma cell leukemia, 4 patients with Waldenström's macroglobulinemia and 7 patients with multiple myeloma; cell lines include 14 myeloid, 15 T-cell, and 10 B-cell lines (all listed in reference [23]) and an epithelial cell line, HeLa (an open triangle). Asterisks denote statistical significance by Scheffe test after combining CML BC, AML and ALL as a group of acute leukemia and DLBCL, FL and other NHL as a group of NHL: * P < 0.05, ** P < 0.01

Aberrant overexpression of an epithelial marker, 14-3-3σ, in a subset of hematological malignancies-2

<p><b>Copyright information:</b></p><p>Taken from "Aberrant overexpression of an epithelial marker, 14-3-3σ, in a subset of hematological malignancies"</p><p>http://www.biomedcentral.com/1471-2407/7/217</p><p>BMC Cancer 2007;7():217-217.</p><p>Published online 25 Nov 2007</p><p>PMCID:PMC2222637.</p><p></p>ose gel. Representative results are shown. The 14-3-3σ mRNA expression levels determined by real-time RT-PCR are shown below. M and U denotes methylated and unmethylated alleles, respectively. PCL denotes plasma cell leukemia; MM, multiple myeloma; CML-CP, chronic phase of chronic myeloid leukemia; PLL, prolymphocytic leukemia

Aberrant overexpression of an epithelial marker, 14-3-3σ, in a subset of hematological malignancies-3

<p><b>Copyright information:</b></p><p>Taken from "Aberrant overexpression of an epithelial marker, 14-3-3σ, in a subset of hematological malignancies"</p><p>http://www.biomedcentral.com/1471-2407/7/217</p><p>BMC Cancer 2007;7():217-217.</p><p>Published online 25 Nov 2007</p><p>PMCID:PMC2222637.</p><p></p> of cell-cycle inhibitors, expression levels are plotted in scattered plots. Open circles denote patients with p53 mutations identified by RT-PCR-SSCP analysis. Correlation coefficients for p53 wild-type and mutated patients are: 14-3-3σ vs. ARF, -0.074 and -0.129; 14-3-3σ vs. CDKN2A, -0.033 and -0.391; ARF vs. CDKN2A, -0.044 and -0.177, respectively

MOESM1 of Development of a new heat tolerance assay system for rice spikelet sterility

Additional file 1: Fig. S1. Time course of changes in set air temperature (T a : solid line), panicle temperatures 1 (T P1: closed circle) and 2 (T P2: opened circle), and water temperature (T W : closed triangle) in the artificial paddy field for 2 days recorded after inserting the fine thermocouples in two spikelets. Panicle temperatures were measured once the flowers were closed, as T P1 and T P2 started at 1 h after insertion of thermocouples. ‘+TC’ and ‘-TC’ indicate the time at insertion and removal of the sensors, respectively. Black bars indicate night. Note that the temperature of water in the paddy displayed diurnal changes according to the changes in air temperature and half of the lamps were turned off for 1 h at the beginning and end of 13 h of daytime, where T P1 and T P2 started to decline prior to the decline in T a

MOESM2 of Development of a new heat tolerance assay system for rice spikelet sterility

Additional file 2: Fig. S2. The high temperature-induced spikelet sterility assay system before improvement in this study. A. The system had a fixed distance from lamp to panicle. Ten plants were planted in the same pot. B. Spikelet fertility of eight rice cultivars [19] was examined at 36 °C/30 °C for 3 days. Values are the mean ± SE of 3–5 plants

Comparison of overall survival between before and after the disaster.

<p>Survival curves were plotted to compare the mortality of each group using the Kaplan-Meier method. The dotted and solid lines indicate the time-to-events of participants before and after the disaster, respectively. The notches within the line represent the censors. The numbers at risk are illustrated below the chart. Overall survival was significantly worse in the group after the disaster (<i>P</i> = 0.029 by log rank test).</p

The influence of the Great East Japan earthquake on microscopic polyangiitis: A retrospective observational study

<div><p>Background</p><p>Antineutrophil cytoplasmic antibody-associated vasculitis is triggered by environmental factors, including silica dust exposure. Repeated tsunami waves brought a large volume of silica-containing sludge inland after the Great East Japan earthquake in 2011. We aimed to determine if the serious disaster influenced the clinical features of the microscopic polyangiitis.</p><p>Methods</p><p>This is an observational retrospective study conducted in a single institute. A total of 43 patients were included based on the CHCC2012 criteria for microscopic polyangiitis from 2007 to 2015. We used the Poisson regression model to determine the incidence of microscopic polyangiitis within the annual population of the medical district. The participants were selected during a 3-year period from before (N = 13) to after the disaster (N = 20). The differences of parameters and the overall survival between the groups were analyzed.</p><p>Results</p><p>The incidence of microscopic polyangiitis increased after the disaster (λ = 17.4/million/year [95%CI: 7.66–39.6] before the disaster and λ = 33.1/million/year [17.7–61.7] after the disaster, <i>P</i> = 0.044). A high Birmingham Activity Score was associated with a high incidence of microscopic polyangiitis after the disaster. The overall survival of the patients with microscopic polyangiitis declined significantly after the disaster.</p><p>Conclusions</p><p>The Great East Japan earthquake influenced the development of the microscopic polyangiitis in our restricted area. The patients who developed after the disaster had severe symptoms and a high mortality rate.</p></div

Change in the annual incidence of microscopic polyangiitis (MPA) in the Ishinomaki medical area.

<p>The incident cases were divided by the population at risk in the restricted medical area and plotted according to annual intervals. The white and black bars represent the incidence per 1 million people before and after the disaster, respectively. The mean incidence of MPA was 17.4 /million/year [95% Confidence Interval (CI): 7.66 to 39.61] before the disaster and 33.1 /million/year [95% CI: 17.73 to 61.74] after the disaster. The dashed line indicates the mean annual incidence of MPA in Japan. The incidence ratio and <i>P</i>-value were obtained using Poisson regression analysis (<i>P</i> = 0.044).</p

Baseline characteristics of 43 MPA patients in this study.

<p>Baseline characteristics of 43 MPA patients in this study.</p

Comparison of factors before and after the GEJE.

<p>Comparison of factors before and after the GEJE.</p