A generic coordination approach applied to a manufacturing environment

This paper describes a generic coordination approach applied to the field of manufacturing engineering. The objective of the coordination mechanism with respect to this application is twofold. Firstly, it is shown that utilising the developed system can result in the efficient organisation of processes leading to a near optimum time taken to manufacture a number of artefacts. Secondly, successful operation of the system in this environment will demonstrate that the approach is generic in nature. The results already achieved using this system within a computational analysis environment supports this hypothesis

An adaptive grid algorithm for one-dimensional nonlinear equations

Richards' equation, which models the flow of liquid through unsaturated porous media, is highly nonlinear and difficult to solve. Step gradients in the field variables require the use of fine grids and small time step sizes. The numerical instabilities caused by the nonlinearities often require the use of iterative methods such as Picard or Newton interation. These difficulties result in large CPU requirements in solving Richards equation. With this in mind, adaptive and multigrid methods are investigated for use with nonlinear equations such as Richards' equation. Attention is focused on one-dimensional transient problems. To investigate the use of multigrid and adaptive grid methods, a series of problems are studied. First, a multigrid program is developed and used to solve an ordinary differential equation, demonstrating the efficiency with which low and high frequency errors are smoothed out. The multigrid algorithm and an adaptive grid algorithm is used to solve one-dimensional transient partial differential equations, such as the diffusive and convective-diffusion equations. The performance of these programs are compared to that of the Gauss-Seidel and tridiagonal methods. The adaptive and multigrid schemes outperformed the Gauss-Seidel algorithm, but were not as fast as the tridiagonal method. The adaptive grid scheme solved the problems slightly faster than the multigrid method. To solve nonlinear problems, Picard iterations are introduced into the adaptive grid and tridiagonal methods. Burgers' equation is used as a test problem for the two algorithms. Both methods obtain solutions of comparable accuracy for similar time increments. For the Burgers' equation, the adaptive grid method finds the solution approximately three times faster than the tridiagonal method. Finally, both schemes are used to solve the water content formulation of the Richards' equation. For this problem, the adaptive grid method obtains a more accurate solution in fewer work units and less computation time than required by the tridiagonal method. The performance of the adaptive grid method tends to degrade as the solution process proceeds in time, but still remains faster than the tridiagonal scheme

A methodology for design coordination in a distributed computing environment

At the conceptual stage of the design process it is increasingly common that analysis tools are involved in the evaluation of a large number of alternative designs. Designers use such analysis tools to assist with large scale concept evaluations and the prediction of good initial designs. Consequently there exists a need to coordinate these analysis tools to enable the early stage of design to be performed in a timely and efficient manner. This paper describes a generic methodology that allows the management and coordination of design analysis tools. A Computer Aided Design tool, namely the Design Coordination System (DCS), has been developed to assist the designer in performing computational analysis in a distributed computing environment. Within the DCS, a collection of design agents act as members of a multi-functional team operating in a cooperative and coordinated manner in order to satisfy the objective of efficiently performing the design analysis

Real-time co-ordinated resource management in a computational enviroment

Design co-ordination is an emerging engineering design management philosophy with its emphasis on timeliness and appropriateness. Furthermore, a key element of design coordination has been identified as resource management, the aim of which is to facilitate the optimised use of resources throughout a dynamic and changeable process. An approach to operational design co-ordination has been developed, which incorporates the appropriate techniques to ensure that the aim of co-ordinated resource management can be fulfilled. This approach has been realised within an agent-based software system, called the Design Coordination System (DCS), such that a computational design analysis can be managed in a coherent and co-ordinated manner. The DCS is applied to a computational analysis for turbine blade design provided by industry. The application of the DCS involves resources, i.e. workstations within a computer network, being utilised to perform the computational analysis involving the use of a suite of software tools to calculate stress and vibration characteristics of turbine blades. Furthermore, the application of the system shows that the utilisation of resources can be optimised throughout the computational design analysis despite the variable nature of the computer network

Non-invasive assessment of pulmonary vascular resistance in pulmonary hypertension: Current knowledge and future direction

Pulmonary Hypertension (PHT) is relatively common, dangerous and under-recognised. Pulmonary hypertension is not a diagnosis in itself; it is caused by a number of differing diseases each with different treatments and prognoses. Therefore, timely and accurate recognition of the underlying cause for PHT is essential for appropriate management. This is especially true for patients with Pulmonary Arterial Hypertension (PAH) in the current era of disease-specific drug therapy. Measurement of Pulmonary Vascular Resistance (PVR) helps separate pre-capillary from post-capillary PHT, and is measured with right heart catheterisation (RHC). Echocardiography has been used to derive a number of non-invasive surrogates for PVR, with varying accuracy. Ultimately, the goal of non-invasive assessment of PVR is to separate PHT due to left heart disease from PHT due to increased PVR, to help streamline investigation and subsequent treatment. In this review, we summarise the physiology and pathophysiology of pulmonary blood flow, the various causes of pulmonary hypertension, and non-invasive surrogates for PVR

A methodology for prospective operational design co-ordination

Engineering companies are continually faced with the challenge of how best to utilise their design team given some design project. Decisions regarding how to distribute the project workload amongst the members of the design team are the responsibility of a project manager who, in order to do this, often relies upon previous experience and/or the support of some planning tool. Furthermore, a project manager rarely has the opportunity to assess the capability of the design team against the current work load in order to determine what, if any, alterations couldbe made to the team to facilitate appropriate reductions in project time and cost.This paper proposes a mathematical-based methodology aimed at identifying shortfalls in design teams, which if remedied would result in a more efficient project in terms of time and cost. The methodology provides a means of identifying those skills within the design team,with respect to the outstanding work load, in which improvements would have the greatest influence on reducing time and cost. In addition, the methodology employs a genetic algorithm for the purpose of scheduling tasks to be undertaken by potential design teams. The methodology is applied to two practical case studies provided by engineering industry.The first case study involves the assessment of a multi-disciplined design team consisting of single-skilled engineers. In contrast, the second case study entails the assessment of multiskilled engineers within a multi-disciplined design team. As a result of applying the methodology to the case studies, potential improvement to the design teams are identified and, subsequently, evaluated by observing their effects

'Special K' and a loss of cell-to-cell adhesion in proximal tubule-derived epithelial cells: modulation of the adherens junction complex by ketamine

Ketamine, a mild hallucinogenic class C drug, is the fastest growing ‘party drug’ used by 16–24 year olds in the UK. As the recreational use of Ketamine increases we are beginning to see the signs of major renal and bladder complications. To date however, we know nothing of a role for Ketamine in modulating both structure and function of the human renal proximal tubule. In the current study we have used an established model cell line for human epithelial cells of the proximal tubule (HK2) to demonstrate that Ketamine evokes early changes in expression of proteins central to the adherens junction complex. Furthermore we use AFM single-cell force spectroscopy to assess if these changes functionally uncouple cells of the proximal tubule ahead of any overt loss in epithelial cell function. Our data suggests that Ketamine (24–48 hrs) produces gross changes in cell morphology and cytoskeletal architecture towards a fibrotic phenotype. These physical changes matched the concentration-dependent (0.1–1 mg/mL) cytotoxic effect of Ketamine and reflect a loss in expression of the key adherens junction proteins epithelial (E)- and neural (N)-cadherin and β-catenin. Down-regulation of protein expression does not involve the pro-fibrotic cytokine TGFβ, nor is it regulated by the usual increase in expression of Slug or Snail, the transcriptional regulators for E-cadherin. However, the loss in E-cadherin can be partially rescued pharmacologically by blocking p38 MAPK using SB203580. These data provide compelling evidence that Ketamine alters epithelial cell-to-cell adhesion and cell-coupling in the proximal kidney via a non-classical pro-fibrotic mechanism and the data provides the first indication that this illicit substance can have major implications on renal function. Understanding Ketamine-induced renal pathology may identify targets for future therapeutic intervention

Real-time co-ordinated scheduling using a genetic algorithm

Real-time co-ordination is an emerging approach to operational engineering management aimed at being more comprehensive and widely applicable than existing approaches. Schedule management is a key characteristic of operational co-ordination related to managing the planning and dynamic assignment of tasks to resources, and the enactment of the resulting schedules, throughout a changeable process. This paper presents the application of an agent-oriented system, called the Design Co-ordination System, to an industrial case study in order to demonstrate the appropriate use of a genetic algorithm for the purpose of real-time scheduling. The application demonstrates that real-time co-ordinated scheduling can provide significant reductions in time to complete the computational design process

A QUALITATIVE STUDY OF LITERACY TUTORING IN VIRTUAL ENVIRONMENTS DURING THE COVID-19 PANDEMIC: INSTRUCTIONAL AND RELATIONAL PRACTICES TO SUPPORT LEARNERS WITH DYSLEXIA

This qualitative collective case study examined the relational and professional practices literacy tutors used to support learners with dyslexia in virtual learning environments during the COVID-19 pandemic. Through individual interviews, literacy tutors who rapidly transitioned to online teaching described their lived experiences during this historic time. Three themes were identified through cross-case analysis: adapting instructional practices to virtual environments, caring for students and parents, and reflecting on professional practice. The results of this study described evidence which suggests implications for future practice, including teacher preparation, virtual tutoring, and reflective teaching