Residential development proposal for a site in Brighton, Massachusetts

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Architecture, and Dept. of Urban Studies and Planning, 1986.MICROFICHE COPY AVAILABLE IN ARCHIVES AN ROTCH.Bibliography: leaves 83-84.by Andrew W. Gutowski and Maria D. Hill.M.S

Maths anxiety in primary and secondary school students: Gender differences, developmental changes and anxiety specificity

Maths anxiety (MA) is a debilitating negative emotional reaction towardsmathematics.However,MA research in primary and early secondary school is surprisingly sparse and inconsistent. Here we tested primary and secondary students' maths and reading performance and their maths and general anxiety (GA). We examined gender differences, developmental changes regarding the MA/maths performance link and investigated whether MA is linked to other academic domains (reading) and/or to other anxiety-types (GA). Results revealed that girls exhibited higherMA than boys at both educational levels.Whilst there was a reliable negative correlation between MA and secondary students' arithmetic performance, no such relationship was revealed in primary students. Finally, MA was moderately correlated with GA and, when GA was partialled out, MA remained significantly correlated with secondary students' arithmetic performance. MA was not related to reading performance when GA was controlled. It was concluded that the negative MA/maths performance link surfaces later in the educational timeline and MA appears to be both exclusively related to maths and independent of GA

Chronic Kidney Disease Increases Cerebral Microbleeds in Mouse and Man.

Brain microbleeds are increased in chronic kidney disease (CKD) and their presence increases risk of cognitive decline and stroke. We examined the interaction between CKD and brain microhemorrhages (the neuropathological substrate of microbleeds) in mouse and cell culture models and studied progression of microbleed burden on serial brain imaging from humans. Mouse studies: Two CKD models were investigated: adenine-induced tubulointerstitial nephritis and surgical 5/6 nephrectomy. Cell culture studies: bEnd.3 mouse brain endothelial cells were grown to confluence, and monolayer integrity was measured after exposure to 5-15% human uremic serum or increasing concentrations of urea. Human studies: Progression of brain microbleeds was evaluated on serial MRI from control, pre-dialysis CKD, and dialysis patients. Microhemorrhages were increased 2-2.5-fold in mice with CKD independent of higher blood pressure in the 5/6 nephrectomy model. IgG staining was increased in CKD animals, consistent with increased blood-brain barrier permeability. Incubation of bEnd.3 cells with uremic serum or elevated urea produced a dose-dependent drop in trans-endothelial electrical resistance. Elevated urea induced actin cytoskeleton derangements and decreased claudin-5 expression. In human subjects, prevalence of microbleeds was 50% in both CKD cohorts compared with 10% in age-matched controls. More patients in the dialysis cohort had increased microbleeds on follow-up MRI after 1.5 years. CKD disrupts the blood-brain barrier and increases brain microhemorrhages in mice and microbleeds in humans. Elevated urea alters the actin cytoskeleton and tight junction proteins in cultured endothelial cells, suggesting that these mechanisms explain (at least in part) the microhemorrhages and microbleeds observed in the animal and human studies

Apparent effect of range size and fruit colour on palm diversification may be spurious

Aim Fruit selection by animal dispersers with different mobility directly impacts plant geographical range size, which, in turn, may impact plant diversification. Here, we examine the interaction between fruit colour, range size and diversification rate in palms by testing two hypotheses: (1) species with fruit colours attractive to birds have larger range sizes due to high dispersal ability and (2) disperser mobility affects whether small or large range size has higher diversification, and intermediate range size is expected to lead to the highest diversification rate regardless of disperser.Location Global.Time Period Contemporary (or present).Major Taxa Studied Palms (Arecaceae).Methods Palm species were grouped based on likely animal disperser group for given fruit colours. Range sizes were estimated by constructing alpha convex hull polygons from distribution data. We examined disperser group, range size or an interaction of both as possible drivers of change in diversification rate over time in a likelihood dynamic model (Several Examined State-dependent Speciation and Extinction [SecSSE]). Models were fitted, rate estimates were retrieved and likelihoods were compared to those of appropriate null models.Results Species with fruit colours associated with mammal dispersal had larger ranges than those with colours associated with bird dispersal. The best fitting SecSSE models indicated that the examined traits were not the primary driver of the heterogeneity in diversification rates in the model. Extinction rate complexity had a marked impact on model performance and on diversification rates.Main Conclusions Two traits related to dispersal mobility, range size and fruit colour, were not identified as the main drivers of diversification in palms. Increased model extinction rate complexity led to better performing models, which indicates that net diversification should be estimated rather than speciation alone. However, increased complexity may lead to incorrect SecSSE model conclusions without careful consideration. Finally, we find palms with more mobile dispersers do not have larger range sizes, meaning other factors are more important determinants of range size

Characterization of HIV-1 RNA forms in the plasma of patients undergoing successful HAART

An assay to characterize plasma human immunodeficiency virus 1 (HIV-1) sequences for patients with low viral loads was developed by combining the selective binding of anti-CD44 MicroBeads with a nested RT-PCR targeting the env C2V4 region. Sequences were obtained from 10 of 20 HIV+ patients who had viral loads below 48 copies/ml. Sequences derived from plasma were compared to those from CD14+ CD16 +monocytes and CD4+ T cells. The plasma sequences were most closely related to those amplified from monocytes, suggesting that during successful antiretroviral therapy, the predominant plasma virus originates from myeloid cells. By characterizing HIV-1 RNA sequences from 8 ml of plasma while avoiding multiple steps, which can lead to contamination and deterioration, this method can help elucidate the viral forms in patients with therapeutically suppressed HIV-1. Understanding the source of residual viremia is crucial in developing approaches for viral eradication

Apparent effect of range size and fruit colour on palm diversification may be spurious

ACKNOWLEDGEMENTS This work was supported by the Biodiversity and Ecosystem Services in a Changing Climate Strategic Research Area at the University of Gothenburg. C.C.S. was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil and the São Paulo Research Foundation (FAPESP; 2020-09164-0). S.F. was supported by the Swedish Research Council (2017-03862); C.D.B. and M.F.T.J. were supported by the Swedish Research Council (2017-04980). The computation was enabled by resources provided by the National Academic Infrastructure for Supercomputing in Sweden (NAISS) and the Swedish National Infrastructure for Computing (SNIC) at PDC and HPC2N, respectively, partially funded by the Swedish Research Council through grant agreements no. 2022-06725 and no. 2018-05973. There were no permits required for this work. Research Funding Biodiversity and Ecosystem Services in a Changing Climate Strategic Research Area Coordenação de Aperfeiçoamento de Pessoal de Nível Superior VetenskapsrådetPeer reviewedPublisher PD

Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system.

Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes. We established a population-based surveillance system to document the direct and indirect impact of PCVs on the incidence of invasive pneumococcal disease (IPD) and radiological pneumonia in those aged 2 months and older in The Gambia, and to monitor changes in serotype-specific IPD. Here we describe how this surveillance system was set up and is being operated as a partnership between the Medical Research Council Unit and the Gambian Government. This surveillance system is expected to provide crucial information for immunisation policy and serves as a potential model for those introducing routine PCV vaccination in diverse settings