Hydroxyapatite deposition disease of the wrist with intraosseous migration to the lunate bone

Hydroxyapatite deposition disease (HADD) is a mostly uniarticular, self-limiting condition caused by deposition of hydroxyapatite (HA) crystals in tendons or in the peritendinous soft tissues. Commonly, the glenohumeral joint is affected. More rarely, the HA depot can be cause of a carpal tunnel syndrome due to an acute inflammatory reaction and space-occupying soft tissue oedema. We report a case of acute HA depot located at the volar site of the right wrist with affection of the deep flexor tendons and intraosseous migration into the lunate bone in a 50-year-old female. There are two main goals of this case report: First, to remind the diagnosis of HADD as a cause of wrist pain and also of carpal tunnel syndrome, as this entity being often misdiagnosed clinically, and second, to report a rare case of intraosseous migration of HA crystals into the lunate bone

Quick-Look Pipeline Light Curves for 5.7 Million Stars Observed Over the Second Year of TESS' First Extended Mission

We present High-Level Science Products (HLSPs) containing light curves from MIT's Quick-Look Pipeline (QLP) from the second year of TESS' first Extended Mission (Sectors 40 - 55; 2021 July - 2022 September). In total, 12.2 million per-sector light curves for 5.7 million unique stars were extracted from 10-minute cadence Full-Frame Images (FFIs) and are made available to the community. As in previous deliveries, QLP HLSPs include both raw and detrended flux time series for all observed stars brighter than TESS magnitude T = 13.5 mag. Starting in Sector 41, QLP also produces light curves for select fainter M dwarfs. QLP has provided the community with one of the largest sources of FFI-extracted light curves to date since the start of the TESS mission.Comment: 3 pages, 1 figur

INTEGRAL and Swift/XRT observations of the source PKS 0208-512

The active galaxy PKS 0208-512, detected at lower energies by COMPTEL, has been claimed to be a MeV blazar from EGRET. We report on the most recent INTEGRAL observations of the blazar PKS 0208-512, which are supplemented by Swift ToO observations. The high energy X-ray and gamma-ray emission of PKS 0208-512 during August - December 2008 has been studied using 682 ks of INTEGRAL guest observer time and ~ 56 ks of Swift/XRT observations. These data were collected during the decay of a gamma-ray flare observed by Fermi/LAT. At X-ray energies (0.2 - 10 keV) PKS 0208-512 is significantly detected by Swift/XRT, showing a power-law spectrum with a photon index of ~ 1.64. Its X-ray luminosity varied by roughly 30% during one month. At hard X-/soft gamma-ray energies PKS 0208-512 shows a marginally significant (~ 3.2 sigma) emission in the 0.5-1 MeV band when combining all INTEGRAL/SPI data. Non-detections at energies below and above this band by INTEGRAL/SPI may indicate intrinsic excess emission. If this possible excess is produced by the blazar, one possible explanation could be that its jet consists of an abundant electron-positron plasma, which may lead to the emission of an annihilation radiation feature. Assuming this scenario, we estimate physical parameters of the jet of PKS 0208-512.Comment: accepted for publication in A&

Efficacy of Chondroprotective Food Supplements Based on Collagen Hydrolysate and Compounds Isolated from Marine Organisms †

Osteoarthritis belongs to the most common joint diseases in humans and animals and shows increased incidence in older patients. The bioactivities of collagen hydrolysates, sulfated glucosamine and a special fatty acid enriched dog-food were tested in a dog patient study of 52 dogs as potential therapeutic treatment options in early osteoarthritis. Biophysical, biochemical, cell biological and molecular modeling methods support that these well-defined substances may act as effective nutraceuticals. Importantly, the applied collagen hydrolysates as well as sulfated glucosamine residues from marine organisms were strongly supported by both an animal model and molecular modeling of intermolecular interactions. Molecular modeling of predicted interaction dynamics was evaluated for the receptor proteins MMP-3 and ADAMTS-5. These proteins play a prominent role in the maintenance of cartilage health as well as innate and adapted immunity. Nutraceutical data were generated in a veterinary clinical study focusing on mobility and agility. Specifically, key clinical parameter (MMP-3 and TIMP-1) were obtained from blood probes of German shepherd dogs with early osteoarthritis symptoms fed with collagen hydrolysates. Collagen hydrolysate, a chondroprotective food supplement was examined by high resolution NMR experiments. Molecular modeling simulations were used to further characterize the interaction potency of collagen fragments and glucosamines with protein receptor structures. Potential beneficial effects of collagen hydrolysates, sulfated glycans (i.e., sulfated glucosamine from crabs and mussels) and lipids, especially, eicosapentaenoic acid (extracted from fish oil) on biochemical and physiological processes are discussed here in the context of human and veterinary medicine