5,227 research outputs found
The empirical process of some long-range dependent sequences with an application to U-statistics
Let (Xj)∞ j = 1 be a stationary, mean-zero Gaussian process with covariances r(k) = EXk + 1 X1 satisfying r(0) = 1 and r(k) = k-DL(k) where D is small and L is slowly varying at infinity. Consider the two-parameter empirical process for G(Xj), where G is any measurable function. Noncentral limit theorems are obtained for FN(x, t) and they are used to derive the asymptotic behavior of some suitably normalized von Mises statistics and U-statistics based on the G(Xj)'s. The limiting processes are structurally different from those encountered in the i.i.d. case
Quick attach and release fluid coupling assembly is self-aligning, self-sealing
Fluid coupling assembly that is self-aligning, self-sealing and contains a bellow ball and socket coupling for quick attach and release is highly reliable and can handle cryogenic fluids where icing is encountered. The fluid coupling assembly is used in many fluid systems but is particularly applicable to cryogenic systems
Power of Change-Point Tests for Long-Range Dependent Data
We investigate the power of the CUSUM test and the Wilcoxon change-point test
for a shift in the mean of a process with long-range dependent noise. We derive
analytiv formulas for the power of these tests under local alternatives. These
results enable us to calculate the asymptotic relative efficiency (ARE) of the
CUSUM test and the Wilcoxon change point test. We obtain the surprising result
that for Gaussian data, the ARE of these two tests equals 1, in contrast to the
case of i.i.d. noise when the ARE is known to be
Power of change-point tests for long-range dependent data
We investigate the power of the CUSUM test and the Wilcoxon change-point tests for a shift in the mean of a process with long-range dependent noise. We derive analytic formulas for the power of these tests under local alternatives. These results enable us to calculate the asymptotic relative efficiency (ARE) of the CUSUM test and the Wilcoxon change point test. We obtain the surprising result that for Gaussian data, the ARE of these two tests equals 1, in contrast to the case of i.i.d. noise when the ARE is known to be 3/Ï€.Herold Dehling and Aeneas Rooch were supported in part by the German Research Foundation (DFG) through the Collaborative Research Center SFB 823 Statistical Modelling of Nonlinear Dynamic Processes. Murad S. Taqqu was supported in part by NSF grant DMS-1309009 at Boston University. (SFB 823 - German Research Foundation (DFG); DMS-1309009 - NSF at Boston University)Published versio
Comment on "Large energy gaps in CaC6 from tunneling spectroscopy: possible evidence of strong-coupling superconductivity"
Comment on "Large energy gaps in CaC6 from tunneling spectroscopy: possible
evidence of strong-coupling superconductivity
Decoupling of Mechanical Structures with Piezoceramic Stacks
A review of the development and realisation of an adaptive interface for decoupling of two mechanical systems is presented. An approach is utilized to design an adaptronical system by means of rapid-prototyping on the basis of a simulation. The method includes the calculation of the dynamic behaviour of the mechanical structure with the help of FEM. The FE-model of the mechanical structure is reduced and embedded as modal state-space-model with the numerical simulation software MATLAB/ Simulink. Actuators and sensors are integrated into the mechanical structure. Based on the resulting dynamical behaviour of the mechanical structure an adaptive control algorithm for the decoupling of structural vibrations is developed. Experimental tests are performed to confirm and to update the simulations. The hardware-in-the-loop-simulation is performed with the commercial rapid-prototyping dSpace-system. This procedure allows the development and the evaluation of more complex adaptive mechanical structures
Clinical and functional characterisation of a novel TNFRSF1A c.605T > A/V173D cleavage site mutation associated with tumour necrosis factor receptor-associated periodic fever syndrome (TRAPS), cardiovascular complications and excellent response to etanercept treatment.
Objectives: To study the clinical outcome, treatment
response, T-cell subsets and functional consequences of a
novel tumour necrosis factor (TNF) receptor type 1
(TNFRSF1A) mutation affecting the receptor
cleavage site.
Methods: Patients with symptoms suggestive of tumour
necrosis factor receptor-associated periodic syndrome
(TRAPS) and 22 healthy controls (HC) were screened for
mutations in the TNFRSF1A gene. Soluble TNFRSF1A and
inflammatory cytokines were measured by ELISAs.
TNFRSF1A shedding was examined by stimulation of
peripheral blood mononuclear cells (PBMCs) with phorbol
12-myristate 13-acetate followed by flow cytometric
analysis (FACS). Apoptosis of PBMCs was studied by
stimulation with TNFa in the presence of cycloheximide
and annexin V staining. T cell phenotypes were monitored
by FACS.
Results: TNFRSF1A sequencing disclosed a novel V173D/
p.Val202Asp substitution encoded by exon 6 in one
family, the c.194–14G.A splice variant in another and
the R92Q/p.Arg121Gln substitution in two families.
Cardiovascular complications (lethal heart attack and
peripheral arterial thrombosis) developed in two V173D
patients. Subsequent etanercept treatment of the V173D
carriers was highly effective over an 18-month follow-up
period. Serum TNFRSF1A levels did not differ between
TRAPS patients and HC, while TNFRSF1A cleavage from
monocytes was significantly reduced in V173D and R92Q
patients. TNFa-induced apoptosis of PBMCs and T-cell
senescence were comparable between V173D patients
and HC.
Conclusions: The TNFRSF1A V173D cleavage site
mutation may be associated with an increased risk for
cardiovascular complications and shows a strong
response to etanercept. T-cell senescence does not seem
to have a pathogenetic role in affected patients
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