13 research outputs found
Accurate Force Field Parameters and pH Resolved Surface Models for Hydroxyapatite to Understand Structure, Mechanics, Hydration, and Biological Interfaces
Mineralization of bone and teeth
involves interactions between
biomolecules and hydroxyapatite. Associated complex interfaces and
processes remain difficult to analyze at the 1 to 100 nm scale using
current laboratory techniques, and prior apatite models for atomistic
simulations have been limited in the representation of chemical bonding,
surface chemistry, and interfacial interactions. In this contribution,
an accurate force field along with pH-resolved surface models for
hydroxyapatite is introduced to represent chemical bonding, structural,
surface, interfacial, and mechanical properties in quantitative agreement
with experiment. The accuracy is orders of magnitude higher in comparison
to earlier models and facilitates quantitative monitoring of inorganic-biological
assembly. The force field is integrated into the AMBER, CHARMM, CFF,
CVFF, DREIDING, GROMACS, INTERFACE, OPLS-AA, and PCFF force fields
to enable realistic simulations of apatite-biological systems of any
composition and ionic strength. Specific properties that are reproduced
well in comparison to experiment include lattice constants (<0.5%
deviation), IR spectrum, cleavage energies, immersion energies in
water (<5% deviation), and elastic constants (<10% deviation).
Interactions between mineral, water, and organic compounds are represented
by standard combination rules without additional adjustable parameters
and shown to achieve quantitative precision. Surface models for common
(001), (010), (020), and (101) facets and nanocrystals are introduced
as a function of pH on the basis of extensive experimental data. New
insights into surface and immersion energies, the structure of aqueous
interfaces, density profiles, and superficial dissolution are described.
Most notably, hydroxyapatite-water interfaces exhibit facet-specific
and pH-specific density profiles. Water stabilizes (010) facets better
than (001) facets in a pH range from 10 to 5, consistent with preferred
nanocrystal shape and growth in the (001) direction observed in experiment.
Towards lower pH values, increasing penetration of water into sub-surface
layers is observed, water density profiles flatten, and superficial
dissolution occurs. The force field and surface models can be applied
to elucidate mechanisms of mineralization as well as specific binding
and assembly of peptides, polymer, and drugs. Extensions to substituted
and defective apatites as well as to other calcium phosphate phases
are feasible
Force Field for Tricalcium Silicate and Insight into Nanoscale Properties: Cleavage, Initial Hydration, and Adsorption of Organic Molecules
Improvements
in the sustainability and durability of building materials
depend on understanding interfacial properties of various mineral
phases at the nanometer scale. Tricalcium silicate (C<sub>3</sub>S)
is the major constituent of cement clinker and we present and validate
a force field for atomistic simulations that provides excellent agreement
with available experimental data, including X-ray structures, cleavage
energies, elastic moduli, and IR spectra. Using this model and available
measurements, we quantify key surface and interface properties of
the dry and superficially hydrated mineral. An extensive set of possible
cleavage planes shows cleavage energies in a range of 1300 to 1600
mJ/m<sup>2</sup> that are consistent with the observation of faceted
crystallites with an aspect ratio near one. Using pure and hydroxylated
surface models that represent the first step in the hydration reaction,
we examined the adsorption mechanism of several organic amines and
alcohols at different temperatures. Strong attraction between −20
and −50 kcal/mol is found as a result of complexation of superficial
calcium ions, electrostatic interactions, and hydrogen bonds on the
ionic surface. Agglomeration of cleaved C<sub>3</sub>S surfaces in
the absence of organic molecules was found to recover less than half
the original cleavage energy (∼450 mJ/m<sup>2</sup>) associated
with reduced Coulomb interactions between reconstructed surfaces.
Additional adsorption of organic compounds below monolayer coverage
reduced the attraction between even surfaces to less than 5% of the
original cleavage energy (∼50 mJ/m<sup>2</sup>) related to
their action as spacers between cleaved surfaces and mitigation of
local electric fields. Computed agglomeration energies for a series
of adsorbed organic compounds correlate with the reduction in surface
forces in the form of measured grinding efficiencies. The force field
is extensible to other cement phases and compatible with many platforms
for molecular simulations (PCFF, COMPASS, CHARMM, AMBER, OPLS-AA,
CVFF)
Carbon Nanotube Dispersion in Solvents and Polymer Solutions: Mechanisms, Assembly, and Preferences
Debundling
and dispersion of carbon nanotubes (CNTs) in polymer
solutions play a major role in the preparation of carbon nanofibers
due to early effects on interfacial ordering and mechanical properties.
A roadblock toward ultrastrong fibers is the difficulty to achieve
homogeneous dispersions of CNTs in polyacrylonitrile (PAN) and poly(methyl
methacrylate) (PMMA) precursor solutions in solvents such as dimethyl
sulfoxide (DMSO), <i>N</i>,<i>N</i>-dimethylacetamide
(DMAc), and <i>N</i>,<i>N</i>-dimethylformamide
(DMF). In this contribution, molecular dynamics simulations with accurate
interatomic potentials for graphitic materials that include virtual
π electrons are reported to analyze the interaction of pristine
single wall CNTs with the solvents and polymer solutions at 25 °C.
The results explain the barriers toward dispersion of SWCNTs and quantify
CNT-solvent, polymer-solvent, as well as CNT-polymer interactions
in atomic detail. Debundling of CNTs is overall endothermic and unfavorable
with dispersion energies of +20 to +30 mJ/m<sup>2</sup> in the pure
solvents, + 20 to +40 mJ/m<sup>2</sup> in PAN solutions, and +20 to
+60 mJ/m<sup>2</sup> in PMMA solutions. Differences arise due to molecular
geometry, polar, van der Waals, and CH-π interactions. Among
the pure solvents, DMF restricts CNT dispersion less due to the planar
geometry and stronger van der Waals interactions. PAN and PMMA interact
favorably with the pure solvents with dissolution energies of −0.7
to −1.1 kcal per mole monomer and −1.5 to −2.2
kcal per mole monomer, respectively. Adsorption of PMMA onto CNTs
is stronger than that of PAN in all solvents as the molecular geometry
enables more van der Waals contacts between alkyl groups and the CNT
surface. Polar side groups in both polymers prefer interactions with
the polar solvents. Higher polymer concentrations in solution lead
to polymer aggregation <i>via</i> alkyl groups and reduce
adsorption onto CNTs. PAN and PMMA solutions in DMSO and dilute solutions
in DMF support CNT dispersion more than other combinations whereby
the polymers significantly adsorb onto CNTs in DMSO solution. The
observations by molecular simulations are consistent with available
experimental data and solubility parameters and aid in the design
of carbon nanofibers. The methods can be applied to other multiphase
graphitic materials
Facet Recognition and Molecular Ordering of Ionic Liquids on Metal Surfaces
Ionic liquids are widely used as
solvents and reaction media due
to low volatility, stability up to high temperature, and large dipole
moment. Emergent applications also aim at the anisotropic growth of
metal nanostructures in ionic liquids through facet-selective interactions
although the governing mechanisms remain poorly understood. We employed
a combination of quantum mechanical and classical simulations to analyze
the structure and energetics of the self-assembly of ionic liquids
on metal surfaces from single ion pairs to multilayers, using the
example of 1-ethyl-3-methylimidazolium ethyl sulfate ([EMIM][ES])
on the crystallographic {111}, {100}, and {110} facets of gold. Adsorption
is controlled by the interplay of soft epitaxy, ionic interactions,
induced charges, and steric effects related to the geometry of the
cation and anion. These factors lead to characteristic molecular patterns
on individual surfaces. Binding energies are similar irrespective
of surface coverage and only slightly increase from {111} to {100}
and {110} surfaces due to stronger surface corrugation and higher
induced charge. The results explain specific experimental observations
and aid in understanding particle growth in ionic liquid media. A
mechanistic hypothesis for the formation of anisotropic gold nanorods
in the presence of silver ions is made, in which silver retards the
growth along {100} and {110} facets through underpotential deposition
Thermodynamically Consistent Force Fields for the Assembly of Inorganic, Organic, and Biological Nanostructures: The INTERFACE Force Field
The complexity of the molecular recognition and assembly
of biotic–abiotic interfaces on a scale of 1 to 1000 nm can
be understood more effectively using simulation tools along with laboratory
instrumentation. We discuss the current capabilities and limitations
of atomistic force fields and explain a strategy to obtain dependable
parameters for inorganic compounds that has been developed and tested
over the past decade. Parameter developments include several silicates,
aluminates, metals, oxides, sulfates, and apatites that are summarized
in what we call the INTERFACE force field. The INTERFACE force field
operates as an extension of common harmonic force fields (PCFF, COMPASS,
CHARMM, AMBER, GROMACS, and OPLS-AA) by employing the same functional
form and combination rules to enable simulations of inorganic–organic
and inorganic–biomolecular interfaces. The parametrization
builds on an in-depth understanding of physical–chemical properties
on the atomic scale to assign each parameter, especially atomic charges
and van der Waals constants, as well as on the validation of macroscale
physical–chemical properties for each compound in comparison
to measurements. The approach eliminates large discrepancies between
computed and measured bulk and surface properties of up to 2 orders
of magnitude using other parametrization protocols and increases the
transferability of the parameters by introducing thermodynamic consistency.
As a result, a wide range of properties can be computed in quantitative
agreement with experiment, including densities, surface energies,
solid–water interface tensions, anisotropies of interfacial
energies of different crystal facets, adsorption energies of biomolecules,
and thermal and mechanical properties. Applications include insight
into the assembly of inorganic–organic multiphase materials,
the recognition of inorganic facets by biomolecules, growth and shape
preferences of nanocrystals and nanoparticles, as well as thermal transitions
and nanomechanics. Limitations and opportunities for further development
are also described
Nanoscale Structure–Property Relationships of Polyacrylonitrile/CNT Composites as a Function of Polymer Crystallinity and CNT Diameter
Polyacrylonitrile
(PAN)/carbon nanotube (CNT) composites are used as precursors for
ultrastrong and lightweight carbon fibers. However, insights into
the structure at the nanoscale and the relationships to mechanical
and thermal properties have remained difficult to obtain. In this
study, molecular dynamics simulation with accurate potentials
and available experimental data were used to describe the influence
of different degrees of PAN preorientation and CNT diameter on the
atomic-scale structure and properties of the composites. The inclusion
of CNTs in the polymer matrix is favored for an intermediate degree
of PAN orientation and small CNT diameter whereas high PAN crystallinity
and larger CNT diameter disfavor CNT inclusion. The glass transition
at the CNT/PAN interface involves the release of rotational degrees
of freedom of the polymer backbone and increased mobility of the protruding
nitrile side groups in contact with the carbon nanotubes. The glass-transition
temperature of the composite increases in correlation with the
amount of CNT/polymer interfacial area per unit volume, i.e., in the
presence of CNTs, for higher CNT volume fraction, and inversely
with CNT diameter. The increase in glass-transition temperature upon
CNT addition is larger for PAN of lower crystallinity than for PAN
of higher crystallinity. Interfacial shear strengths of the composites
are higher for CNTs of smaller diameter and for PAN with preorientation,
in correlation with more favorable CNT inclusion energies. The lowest
interfacial shear strength was observed in amorphous PAN for the same
CNT diameter. PAN with ∼75% crystallinity exhibited hexagonal
patterns of nitrile groups near and far from the CNT interface which
could influence carbonization into regular graphitic structures. The
results illustrate the feasibility of near-quantitative insights into
macroscale properties of polymer/CNT composites from simulations of
nanometer-scale composite domains. Guidance is most effective when
key assumptions in experiment and simulation are closely aligned,
such as exfoliation versus bundling of CNTs, size, type, potential
defects of CNTs, and precise measures for polymer crystallinity
Understanding Chemical Bonding in Alloys and the Representation in Atomistic Simulations
Alloys
are widely used in catalysts and structural materials. The
nature of chemical bonding and the origin of alloy formation energies,
defect energies, and interfacial properties have not been well understood
to date but are critical to material performance. In this contribution,
we explain the polar nature of chemical bonding and an implementation
in classical and reactive atomistic simulations to understand such
properties more quantitatively. Electronegativity differences between
metal atoms lead to polar bonding, and exothermic alloy formation
energies are related to charge transfer between the different elements.
These differences can be quantified by atomic charges using pairwise
charge increments, determined by matching the computed alloy
formation energy to experimentally measured alloy formation energies
using pair potentials for the pure metals. The polar character of
alloys is comparable to organic molecules and partially ionic minerals,
for example, AlNi and AlNi<sub>3</sub> alloys assume significant atomic
charges of ±0.40<i>e</i> and +0.60<i>e</i>/–0.20<i>e</i>, respectively. The subsequent analysis
of defect sites and defect energies using force-field-based calculations
shows excellent agreement with calculations using density functional
theory and embedded atom models (EAM). The formation of vacancy and
antisite defects is characterized by a redistribution of charge in
the first shell of neighbor atoms in the classical models whereby
electroneutrality is maintained and charge increments correlate with
differences in electronegativity. The proposed atomic charges represent
internal dipole and multipole moments, consistent with existing definitions
for organic and inorganic compounds and with the extended Born model
(Heinz, H.; Suter, U. W. <i>J. Phys. Chem. B</i> <b>2004,</b> <i>108</i> (47), 18341–18352). The method can be
applied to any alloy and has a reproducibility of ±10%. In contrast,
quantum mechanical charge schemes remain associated with deviations
exceeding ±100%. The atomic charges for alloys provide a simple
initial measure for the internal electronic structure, surface adsorption
of molecules, and reactivity in catalysis and corrosion. The models
are compatible with the Interface force field (IFF), CHARMM, AMBER,
OPLS-AA, PCFF, CVFF, and GROMOS for reliable atomistic simulations
of alloys and their interfaces with minerals and electrolytes from
the nanometer scale to the micrometer scale
A Rational Biomimetic Approach to Structure Defect Generation in Colloidal Nanocrystals
Controlling the morphology of nanocrystals (NCs) is of paramount importance for both fundamental studies and practical applications. The morphology of NCs is determined by the seed structure and the following facet growth. While means for directing facet formation in NC growth have been extensively studied, rational strategies for the production of NCs bearing structure defects in seeds have been much less explored. Here, we report mechanistic investigations of high density twin formation induced by specific peptides in platinum (Pt) NC growth, on the basis of which we derive principles that can serve as guidelines for the rational design of molecular surfactants to introduce high yield twinning in noble metal NC syntheses. Two synergistic factors are identified in producing twinned Pt NCs with the peptide: (1) the altered reduction kinetics and crystal growth pathway as a result of the complex formation between the histidine residue on the peptide and Pt ions, and (2) the preferential stabilization of {111} planes upon the formation of twinned seeds. We further apply the discovered principles to the design of small organic molecules bearing similar binding motifs as ligands/surfactants to create single and multiple twinned Pd and Rh NCs. Our studies demonstrate the rich information derived from biomimetic synthesis and the broad applicability of biomimetic principles to NC synthesis for diverse property tailoring
РП Спецсеминар Совр. проблемы биофизики, биологии и биотех-и 2015 с печатью
Silica
nanostructures find applications in drug delivery, catalysis,
and composites, however, understanding of the surface chemistry, aqueous
interfaces, and biomolecule recognition remain difficult using current
imaging techniques and spectroscopy. A silica force field is introduced
that resolves numerous shortcomings of prior silica force fields over
the last 30 years and reduces uncertainties in computed interfacial
properties relative to experiment from several 100% to less than 5%.
In addition, a silica surface model database is introduced for the
full range of variable surface chemistry and pH (Q<sup>2</sup>, Q<sup>3</sup>, Q<sup>4</sup> environments with adjustable degree of ionization)
that have shown to determine selective molecular recognition. The
force field enables accurate computational predictions of aqueous
interfacial properties of all types of silica, which is substantiated
by extensive comparisons to experimental measurements. The parameters
are integrated into multiple force fields for broad applicability
to biomolecules, polymers, and inorganic materials (AMBER, CHARMM,
COMPASS, CVFF, PCFF, INTERFACE force fields). We also explain mechanistic
details of molecular adsorption of water vapor, as well as significant
variations in the amount and dissociation depth of superficial cations
at silica–water interfaces that correlate with ζ-potential
measurements and create a wide range of aqueous environments for adsorption
and self-assembly of complex molecules. The systematic analysis of
binding conformations and adsorption free energies of distinct peptides
to silica surfaces will be reported separately in a companion paper.
The models aid to understand and design silica nanomaterials in 3D
atomic resolution and are extendable to chemical reactions
Prediction of Specific Biomolecule Adsorption on Silica Surfaces as a Function of pH and Particle Size
Silica
nanostructures are biologically available and find wide
applications for drug delivery, catalysts, separation processes, and
composites. However, specific adsorption of biomolecules on silica
surfaces and control in biomimetic synthesis remain largely unpredictable.
In this contribution, the variability and control of peptide adsorption
on silica nanoparticle surfaces are explained as a function of pH,
particle diameter, and peptide electrostatic charge using molecular
dynamics simulations with the CHARMM-INTERFACE force field. Adsorption
free energies and specific binding residues are analyzed in molecular
detail, providing experimentally elusive, atomic-level information
on the complex dynamics of aqueous electric double layers in contact
with biological molecules. Tunable contributions to adsorption are
described in the context of specific silica surface chemistry, including
ion pairing, hydrogen bonds, hydrophobic interactions, and conformation
effects. Remarkable agreement is found for computed peptide binding
as a function of pH and particle size with respect to experimental
adsorption isotherms and ζ-potentials. Representative surface
models were built using characterization of the silica surfaces by
transmission electron microscopy (TEM), scanning electron microscopy
(SEM), Brunauer–Emmett–Teller (BET), thermalgravimetric
analysis (TGA), ζ-potential, and surface titration measurements.
The results show that the recently introduced interatomic potentials
(Emami et al. <i>Chem. Mater.</i> <b>2014</b>, <i>26</i>, 2647) enable computational screening of a limitless
number of silica interfaces to predict the binding of drugs, cell
receptors, polymers, surfactants, and gases under realistic solution
conditions at the scale of 1 to 100 nm. The highly specific binding
outcomes underline the significance of the surface chemistry, pH,
and topography