Daily activities and survival at older ages

This study tested the hypothesis that time spent on regenerative (e.g., resting), productive (e.g., housework), and consumptive activities (e.g., meeting friends) is associated with survival in persons aged 70 and older. An observational study with semi-annual mortality follow-ups was carried out in the former West Berlin, Germany. The sample was stratified by age and sex and consisted of 473 persons aged 70 to 103 years. Study participants lived in the community as well as in institutions. Activity measures were assessed in 1990-1993 by structured interviews in the participants´ homes. Cox regression was used to model survival from time of interview. The main outcome measure was survival on 3 February 2000. Consumptive activities were related to survival (relative risk = 0.76, 95% confidence interval 0.58 to 1.00) after several confounding factors were controlled for. There were indications that the greatest survival benefit is achieved with a medium amount of time devoted to consumptive activities. Our results support the idea that daily activities are linked to survival via a psychosocial pathway, which might involve perceived quality of life. Consumptive activities (e.g., meeting friends, reading a novel) may contribute considerably to maintaining health and achieving longevity, because they are performed on a daily basis and their effects may accumulate over the life course.

Month of birth influences survival up to age 105+: first results from the age validation study of German semi-supercentenarians

Using data from Germany, we examine if month of birth influences survival up to age 105. Since age reporting at the highest ages is notoriously unreliable we draw on age-validated information from a huge age validation project of 1487 alleged German semi-supercentenarians aged 105+. We use month of birth as an exogenous indicator for seasonal changes in the environment around the time of birth. We find that the seasonal distribution of birth dates changes with age. For 925 age-validated semi-supercentenarians the seasonality is more pronounced than at the time of their births (1880-1900). Among the December-born the relative risk of survival from birth to age 105+ is 16 per cent higher than the average, among the June-born, 23 per cent lower. The month-of-birth pattern in the survival risks of the German semi-supercentenarians resembles closely the month-of-birth pattern in remaining life expectancy at age 50 in Denmark.

Auf der schiefen Bahn: Die deutsche Lohnpolitik verschärft die Krise

Die Wachstumsschwäche der deutschen Wirtschaft fordert Erklärungsansätze heraus. Während viele Ökonomen die Ursachen für die deutsche Wachstums- und Beschäftigungskrise bei den Angebotsbedingungen sehen, plädieren Dr. Heiner Flassbeck und Remi Maier-Rigaud dafür, der Nachfrageseite und der Lohnpolitik mehr Beachtung zu schenken. --

Exceptional Lifespans

How long can humans live? This open access book documents, verifies and brings to life the advance of the frontier of human survival. It carefully validates data on supercentenarians, aged 110+, and semi-supercentenarians, aged 105-109, stored in the International Database on Longevity (IDL). The chapters in this book contribute substantial advances in rigorously checked facts about exceptional lifespans and in the application of state-of-the-art analytical strategies to understand trends and patterns in these rare lifespans. The book includes detailed accounts of extreme long-livers and how their long lifespans were documented, as well as reports on the causes of death at the oldest ages. Its key finding, based on the analysis of 1,219 validated supercentenarians, is that the annual probability of death is constant at 50% after age 110. In contrast to previous assertions about a ceiling on the human lifespan, evidence presented in this book suggests that lifespan records in specific countries and globally will be broken again and again as more people survive to become supercentenarians.

implications for joint remodeling in AS

Introduction In ankylosing spondylitis (AS), joint remodeling leading to joint ankylosis involves cartilage fusion. Here, we analyzed whether chondrocyte hypertrophy is involved in cartilage fusion and subsequent joint remodeling in AS. Methods We assessed the expression of chondrocyte hypertrophy markers runt-related transcription factor 2 (Runx2), type X collagen (COL10), matrix metalloproteinase 13 (MMP13), osteocalcin and beta-catenin and the expression of positive bone morphogenic proteins (BMPs) and negative regulators (dickkopf-1 (DKK-1)), sclerostin, (wingless inhibitory factor 1 (wif-1)) of chondrocyte hypertrophy in the cartilage of facet joints from patients with AS or osteoarthritis (OA) and from autopsy controls (CO) by immunohistochemistry. Sex determining region Y (SRY)-box 9 (Sox9) and type II collagen (COL2) expression was assessed as indicators of chondrocyte integrity and function. Results The percentage of hypertrophic chondrocytes expressing Runx2, COL10, MMP13, osteocalcin or beta-catenin was significantly increased in OA but not in AS joints compared to CO joints. Frequencies of sclerostin-positive and DKK-1-positive chondrocytes were similar in AS and CO. In contrast, wif-1- but also BMP-2- and BMP-7-expressing and Sox9-expressing chondrocytes were drastically reduced in AS joints compared to CO as well as OA joints whereas the percentage of COL2-expressing chondrocytes was significantly higher in AS joints compared to CO joints. Conclusions We found no evidence for chondrocyte hypertrophy within hyaline cartilage of AS joints even in the presence of reduced expression of the wnt inhibitor wif-1 suggesting that chondrocyte hypertrophy is not a predominant pathway involved in joint fusion and remodeling in AS. In contrast, the reduced expression of Sox9, BMP-2 and BMP-7 concomitantly with induced COL2 expression rather point to disturbed cartilage homeostasis promoting cartilage degeneration in AS