The Impact of Disease Registries on Advancing Knowledge and Understanding of Dementia Globally

To help address the increasing challenges related to the provision of dementia care, dementia registries have emerged around the world as important tools to gain insights and a better understanding of the disease process. Dementia registries provide a valuable source of standardized data collected from a large number of patients. This review explores the published research relating to different dementia registries around the world and discusses how these registries have improved our knowledge and understanding of the incidence, prevalence, risk factors, mortality, diagnosis, and management of dementia. A number of the best-known dementia registries with high research output including SveDem, NACC, ReDeGi, CREDOS and PRODEM were selected to study the publication output based on their data, investigate the key findings of these registry-based studies. Registries data contributed to understanding many aspects of the disease including disease prevalence in specific areas, patient characteristics and how they differ in populations, mortality risks, as well as the disease risk factors. Registries data impacted the quality of patients’ lives through determining the best treatment strategy for a patient based on previous patient outcomes. In conclusion, registries have significantly advanced scientific knowledge and understanding of dementia and impacted policy, clinical practice care delivery

Physico-chemical and mechanical characteristics and durability of calcium aluminate blended cement.

abstract: In this investigation, the hydration characteristics and microstructure of calcium aluminate cement (CAC) contg. different proportions of high slag (HSC) and sulfate resisting cements (SRC) were studied. The blends were made from CAC with the partial replacement of HSC or SRC of 5, 10, 15, 20 and 25 mass%. 10 Mass% of silica fume (SF) was added to all mixes contg. SRC to act as a pozzolanic material to react with the liberated Ca(OH)2 formed during the hydration of the SRC forming addnl. C-S-H and stratlingite (C2ASH8). The prepd. specimens were tested for their compressive strength, hydration characteristics and examd. by XRD, DTA, FT-IR spectroscopy and SEM. The effect of HSC added to the CAC on the resistivity against some aggressive media such as 5% NaCl or 5% MgSO4 was also investigated. The results of compressive strength of pastes made of mix compns. contg. HSC show its max. at M.20 (20 mass% HSC). With an increase of HSC content up to 25 mass%, the strength decreased. On the other hand, the strength values of the pastes cured for 1 and 3 days decreased sharply with the percent content of SRC, but, it increases for paste contg. 5 mass% cured for 7 and 28 days. The compressive strength values of specimens immersed in 5 mass% NaCl or 5 mass% MgSO4 increases up to M.20 (20 mass% HSC) at all curing ages up to 120 days. The increase of the BFSC content up to 25 mass% (M.25) was accompanied by a corresponding strength redn. [on SciFinder(R)] Cited Reference: Citations: 1) Midgley, H; Mag Concr Res 1975, 27, 59|2) Edmonds, R; Cem Concr Res 1989, 19, 779|3) Majumdar, A; Eur Pat Appl, No 88309527.5 1989, 9|4) Jefferis, S; Calcium Alumina Cement 1990, 363|5) Majumdar, A; EP 0/312/323 1989|6) Fu, Y; US Patent Application, No 08/377/109 1995|7) Ding, J; MASC Thesis, Department of Civil Engineering, University of Ottawa 1995|8) Radwan, M; Ind Ceram 2001, 21, 3|9) Ping, J; J Mater Sci 1997, 32, 3875|10) Midgley, H; Trans Brit Ceram Soc 1967, 66, 161|11) Midgley, H; Cem Concr Res 1978, 8, 169|12) Bentsen, S; Calcium Aluminate Cement 1990, 294|13) ASTM Standards Cement 1979(C204 - 79)|14) Anon; Bestimmung der Rohdichte 1985(DIN 51 064)|15) Anon; Bestimmung der Offenen Porositat 1985(DIN 51 056)|16) Hennin, O; Wiss Z, Hochsch Archit Banwes Weimar 1972, 19|17) Fentiman, C; Calcium Aluminate Cements 1990|18) Taylor, H; Cement Chemistry 1990|19) Ding, J; Cem Concr Res 1995, 25(6), 1311|20) Fu, Y; ACI Materi J 1997, 94, 54

Maximizing the utilization of solar energy in drying of potato

This study was proceeded to adjudge a maximizing the utilization of solar Energy in the drying of potato, Experimental work was proceeded under different levels of temperature and thickness of Potato slices “2-3mm” at constant air velocity of 0.78 m/min. The experimental measurements included moisture content Potato slices, air temperature, air relative humidity, solar drying efficiency and changes of the drying rate Potato Measuring the utilization rate of solar energy, with mirrors or without mirrors. The moisture content of potato decreased from 80.9 to 5.55 kg/kg for potato slices treated using mirrors, this decrease in moisture content was greater than when the slides were not treated and without mirrors

Design of Targeted Flurbiprofen Biomimetic Nanoparticles for Management of Arthritis: In Vitro and In Vivo Appraisal

Flurbiprofen (FLUR) is a potent non-steroidal anti-inflammatory drug used for the management of arthritis. Unfortunately, its therapeutic effect is limited by its rapid clearance from the joints following intra-articular injection. To improve its therapeutic efficacy, hyaluronic acid-coated bovine serum albumin nanoparticles (HA-BSA NPs) were formulated and loaded with FLUR to achieve active drug targeting. NPs were prepared by a modified nano-emulsification technique and their HA coating was proven via turbidimetric assay. Physicochemical characterization of the selected HA-BSA NPs revealed entrapment efficiency of 90.12 ± 1.06%, particle size of 257.12 ± 2.54 nm, PDI of 0.25 ± 0.01, and zeta potential of −48 ± 3 mv. The selected formulation showed in-vitro extended-release profile up to 6 days. In-vivo studies on adjuvant-induced arthritis rat model exhibited a significant reduction in joint swelling after intra-articular administration of FLUR-loaded HA-BSA NPs. Additionally, there was a significant reduction in CRP level in blood as well as TNF-α, and IL-6 levels in serum and joint tissues. Immunohistochemical study indicated a significant decrease in iNOS level in joint tissues. Histopathological analysis confirmed the safety of FLUR-loaded HA-BSA NPs. Thus, our results reveal that FLUR loaded HA-BSA NPs have a promising therapeutic effect in the management of arthritis