La formación docente en momentos de cambios: ¿Qué nos dicen los profesores principiantes universiatrios?

Este estudio cualitativo con una metodología de estudios de casos múltiple examina la opinión de los profesores principiantes de la Universidad de Barcelona sobre las consecuencias del proceso de implementación del Espacio Europeo de Educación Superior (EEES). Indaga sobre la valoración que realiza el profesorado sobre la formación recibida en el postgrado de 'Iniciación a la docencia universitaria' y sobre los aprendizajes que les generó la experiencia formativa. La muestra de la investigación ha estado constituida por diez profesores principiantes de diferentes ámbitos de conocimiento de la Universidad de Barcelona y los datos proceden de la realización de entrevistas en profundidad. Entre los hallazgos más importantes, cabe destacar su percepción sobre la implementación del EEES y las propuestas que dan sobre los cambios que debería realizar la Universidad para una verdadera reforma de la formación de los docente

Representative electropherograms of <i>TP53</i> mutated GIST samples.

<p><i>TP53</i> mutations were detected by Sanger sequencing. Representative electropherograms are shown for each <i>TP53</i> mutated sample (A-I) in the same order as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0193048#pone.0193048.t001" target="_blank">Table 1</a>. Six mutations resulted in a non-functional p53 (A-D, F, I), two mutations resulted in a partially functional p53 (G-H) and one mutation could be detected without influence on the p53 function (E).</p

Model of cell cycle regulators and apoptosis modulators that are associated with impaired p53 (TP53) function in GIST.

<p>Constitutive activated KIT or PDGFRA promotes proliferation and can be inhibited by imatinib. Impaired p53 function leads as well to a higher proliferation and inhibits apoptosis by modulation of cell cycle regulators. The analyzed proteins are displayed as circles with a bold boarder. Filled green circles indicate that this protein is associated with a favorable recurrence free survival in our study, filled red circles indicate that these regulators are associated with an unfavorable recurrence free survival.</p

Representative immunohistochemical stainings of CDK4, MDM2,p53, p21 and p16 expression.

<p>The expression of different proteins was evaluated by immunohistochemistry. In (A), (C), (E), (G) and (I) the representative high expression pattern of CDK4, MDM2 and p53 (TP53) in different GISTs are shown in contrast to the non/low expression patterns (B), (D), (F), (H) and (J) (100x).</p

Clinical and histopathological findings of GIST with TP53 mutations.

<p>Clinical and histopathological findings of GIST with TP53 mutations.</p

Recurrence free survival of patients with CDK4, MDM2 and p53 expression or <i>TP53</i> mutated tumors.

<p>Kaplan-Meier survival curve showing analysis of recurrence free survival in patients from the SSGXVIII study. A high expression of CDK4 is positively correlated with recurrence free survival (red line, p = 0.01) in contrast to a high expression of MDM2 and p53 (TP53, red line, p = 0.06 and p = 0.01, respectively, log-rank test). <i>TP53</i> mutations tend to correlate to a worse recurrence free survival but did not reach significant levels due to a small number of mutated tumors (p = 0.24, log-rank test).</p

Main immunohistochemical findings of this study.

<p>Main immunohistochemical findings of this study.</p

Association of expression of 8 proteins in primary GIST with recurrence-free survival in the SSGXVIII trial.

<p>Association of expression of 8 proteins in primary GIST with recurrence-free survival in the SSGXVIII trial.</p