Influence of the Bowtie Shaped Dimples on the Performance of Sliding Surfaces under Hydrodynamic Lubrication

It covers the tribological behaviour of sliding surfaces, one of which has bowtie-shaped micro-dimples. Against the other fixed, textured wall, one wall is smooth and moving at a constant speed. For the formation of hydrodynamic pressure and tribological behaviour, the effects of bowtie-shaped dimples and orientated bowtie-shaped dimples have been compared with circular-shaped dimples. Additionally, the impact of sliding speed, dimple area density, and dimple depth on tribological behaviour was examined. The findings show that compared to a circular-shaped dimple, an atypical bowtie-shaped and orientated bowtie-shaped dimple generates a higher net hydrodynamic pressure in the fluid domain and offers improved stability between the sliding surfaces. It has been demonstrated that geometrical factors like dimple depth and area density as well as operational factors like sliding speed have a substantial impact on the hydrodynamic average pressure and tribological behaviour of sliding surfaces. The experimental results support the conclusions from the analysis and CFD

Design & Modeling of Special Purpose Equipment for Shell-diaphragm Welding in Conveyor Pulley

AbstractAt the present time in many material handling industries, need and capacity of conveying equipments are increasing rapidly. Conveyor pulleys have been recognized as a most necessary component of the conveyor system. As a result of these demand of conveyor pulley increasing day by day. Various types of pulleys are used for conveying systems. Here a focus is on the high tension pulleys where the use of custom made engineered welded steel pulley is dictated due to its higher capacity and ease of manufacturing. Requirement of various sizes conveyor pulleys are there as a result of various size of conveying systems are to be designed. It is now compulsory for the conveyor pulley manufacturer to increase the production rate. To be specific industries want a special purpose machine which in turn useful according to various diameter and various length of pulleys. Even they have to supply it on time with less cost to fulfill the customer needs. So an attempt is made to design special purpose equipments for Shell-Diaphragm Welding in Conveyor Pulley which is useful to increase the productivity and quality of the product

Study Of Phenothiazine On p53 Core Domain Mutant Y220C: Finding The Anti-tumor Activity Of Phenothiazine

The tumor suppressor protein p53 is a transcription factor that plays a key role in the prevention of cancer development. The p53 cancer mutation Y220C induces formation of a cavity on the protein's surface that can accommodate stabilizing small molecules. We have attempted with the help of virtual screening and molecular docking approach using Lamarckian Genetic Algorithm to elucidate the extent of specificity of p53 cancer mutation Y220C towards different class of Phenothiazines (an anti-cancer agent). 

The 393 residue p53 tumor suppressor protein exists in a dynamic equilibrium to form homotetramers. Each chain comprises several functional domains. The N terminal part of the protein consists of the trans-activation domain (residues 1–63) followed by a proline rich region (64– 92). The central (core) domain (p53 core domain) is responsible for binding. The C terminal part of p53 contains the tetramerization domain (residues 326–355) and the negative regulatory domain at the extreme C terminus (363–393), which contains phosphorylation and acetylation sites and regulates the DNA binding activity of p53.

The docking result of the study of 2,000 Phenothiazines demonstrated that the binding energies were in the range of -10.54 kcal/mol to -1.14 kcal/mol, with 8 molecules showing hydrogen bonds with the active site residues (Lys 164). All the selected 2000 inhibitors were selected on the basis of the structural specificity to the enzyme towards its substrate and inhibitors. Our research provides a blueprint for the design of more potent and specific drugs that rescue p53-Y220C

ASSOCIATION OF SUBCLINICAL HYPOTHYROIDISM WITH METABOLIC SYNDROME: A CROSSSECTIONAL STUDY FROM WESTERN INDIA

ABSTRACTObjective: Metabolic syndrome (MetS) and subclinical hypothyroidism (SCH) both are known to have adverse cardiovascular outcomes. Availablestudies have shown variable results on the association of SCH with MetS as well as individual components of MetS. We aimed to study the associationof SCH with MetS and its individual components of MetS.Methods: This cross-sectional study was carried out in individuals volunteered for health checkup at tertiary care teaching hospital in Western India.About 60 cases with MetS and 120 controls without having MetS were recruited. Demographic data such as history of diabetes mellitus, hypertension,dyslipidemia, blood pressure (BP), waist circumference and serum T3, serum T4, thyroid stimulating hormone, fasting blood sugar, fasting lipidprofile, and hemoglobin A1c were collected and statistically analyzed. Statistical analysis was done by using SPSS sav software packages. Chi-squaretest was used for the comparison of qualitative data.Results: SCH was present in 52 (28.9%) among 180 study participants. SCH was present in 35 (58.33%) participants having MetS and in 17 (14.16%)of controls. There was a strong association between SCH and MetS (p<0.001). Significant association of SCH with diastolic BP (p=0.017) and withcentral obesity (p=0.004) was observed but not with high-density lipoprotein, triglyceride, hyperglycemia, systolic BP, total cholesterol, and lowdensitylipoprotein.Conclusion: We observed a strong association of SCH with MetS. We also observed significant association of SCH with diastolic BP and with obesity.The finding of this study indicates the need to screen individuals with MetS for SCH.Keywords: Central obesity, Diastolic blood pressure, Hypertriglyceridemia, Hypertension, Cardiovascular morbidity, Inflammation, Insulin resistance,Low-density lipoprotein, High-density lipoprotein.Â

Rare mutations and potentially damaging missense variants in genes encoding fibrillar collagens and proteins involved in their production are candidates for risk for preterm premature rupture of membranes

Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm birth with ~ 40% of preterm births being associated with PPROM and occurs in 1% - 2% of all pregnancies. We hypothesized that multiple rare variants in fetal genes involved in extracellular matrix synthesis would associate with PPROM, based on the assumption that impaired elaboration of matrix proteins would reduce fetal membrane tensile strength, predisposing to unscheduled rupture. We performed whole exome sequencing (WES) on neonatal DNA derived from pregnancies complicated by PPROM (49 cases) and healthy term deliveries (20 controls) to identify candidate mutations/variants. Genotyping for selected variants from the WES study was carried out on an additional 188 PPROM cases and 175 controls. All mothers were self-reported African Americans, and a panel of ancestry informative markers was used to control for genetic ancestry in all genetic association tests. In support of the primary hypothesis, a statistically significant genetic burden (all samples combined, SKAT-O p-value = 0.0225) of damaging/potentially damaging rare variants was identified in the genes of interest—fibrillar collagen genes, which contribute to fetal membrane strength and integrity. These findings suggest that the fetal contribution to PPROM is polygenic, and driven by an increased burden of rare variants that may also contribute to the disparities in rates of preterm birth among African Americans

Arthroscopic treatment of displaced tibial eminence fractures using wire loop technique

Background: Several techniques of arthroscopic treatment of tibial spine avulsion fractures have been described in the literature. We conducted a study to analyze the results of arthroscopic assisted wire loop technique for treatment of tibial spine avulsion in adults and pediatric patients.Methods: From June 2011 to December 2016, 52 patients with tibial spine fractures were surgically treated with arthroscopic reduction and wire loop fixation. Forty-four patients were adults and eight were in their pediatric age group. The age group ranged from 9 years to 52 years with the mean age of 26.2 years. 28 patients were type 2 and 24 were of type 3 fracture as classified by Myeres and Mckeever’s classification. The final analysis was done using clinical tests, radiological evaluation and International Knee Documentation Committee (IKDC) and Lysholm score.Results: At final follow-up, the mean IKDC and Lysholm knee scores were, 92 and 93 respectively. All patients had a complete functional recovery and were able to return to work and to resume their activities.Conclusions: Arthroscopic wire loop fixation is an excellent method for tibial eminence fracture in adults and children which gives excellent results in form of control tension on ACL on each side of avulsed fragment and also gives adequate mechanical strength for early rehabilitation

Argos, a replicable genome information system for FlyBase, euGenes and other databases.

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