A Non-Linear Offset-Free Model Predictive Control Design Approach

This paper presents a non-linear model predictive control approach for offset-free tracking and the rejection of piece-wise constant disturbances. The approach involves augmenting the system’s state vector with the integral of the tracking error, enabling the design of a non-linear model predictive controller for this augmented system. Nominal closed-loop stability is enforced thanks to a terminal equality constraint and proven by a Lyapunov argument. Compared to the existing offset-free approaches in the literature, our method offers greater simplicity, as it does not rely on linear approximations of the system to control. Furthermore, it eliminates the need to estimate disturbances, a task that is especially challenging with non-linear systems. Comprehensive simulations and experimental tests are conducted according to a non-linear, coupled, two-tank laboratory experiment, demonstrating the robustness and effectiveness of the proposed approach.</p

Supplementary document for Annotation-efficient learning for OCT segmentation - 6409495.pdf

K-fold cross-validation of our result

Model for Estimating Anthropogenic Nutrient diScharges with high Temporal and Spatial resolution dataset (MEANS-ST1.0)

The MEANS-ST1.0 dataset consists of a "Data File" and a "Readme File". The "Data File" serve as the core file, while the "Readme File" provides explanations of abbreviations and units, along with a list of key parameters. Within the data files, we offer three different formats of anthropogenic pollutant discharge datasets. The first format is stored as GeoTIFF files, which can be used in conjunction with GIS software for overall characterization and spatial distribution analysis. The spatial resolution is 1 km, covering three representative years (1980, 2000, and 2020) and providing data on total anthropogenic nitrogen discharges, as well as discharges from five types of anthropogenic pollutant sources: urban residential, rural residential, industry, crop farming and livestock farming. The second format comprises ten NetCDF files, suitable for constructing two-dimensional or multi-dimensional models and conducting data visualization analysis. These files have a spatial resolution of 1 km and contain monthly data for different years (1980, 2000, and 2020) on total TN and TP discharges and five types of anthropogenic pollutant sources. The third format of the dataset is Excel files, supporting the construction of a national integrated model and providing yearly data on anthropogenic pollutant discharges for provincial administrative units, including both total and categorized discharges. The MEANS-ST1.0 dataset incorporates the most comprehensive spatiotemporal dynamic parameters, enabling a fine-grained analysis of the long-term dynamics for China's anthropogenic nutrient discharges from both spatial and temporal perspectives

Correlation of AR-mediated reporter activities between designer yeast and mammalian systems.

(A) Schematic representation of our designer yeast platform compared with the mammalian luciferase reporter system. (B) The list of 56 PCa-associated AR-LBD mutations accumulated in ARDB during a 22-year period (from 1990 to 2012). Top ten frequent mutations were marked in blue. (C), The Correlation analyses were based on fold changes in activation of AR-LBD mutants as normalized to the wild-type AR between the yeast and mammalian reporter systems, using the top ten frequent mutations in (B) against a variety of concentrations of DHT, E2, PROG, and CPA. Pearson’s correlation coefficient (R) and P-values were listed in the figures. Hormone concentrations in the yeast assay were DHT 10−8 M, E2 10−5 M, PROG 10−5 M, and CPA 10−5 M. Hormone concentrations in the human Hep3B reporter assay were DHT 10−9 M, E2 10−7 M, PROG 10−9 M, and CPA 10−7 M.</p

The plots of Fig 1C were created in R using the ‘ggpubr’ package.

The R codes as well as the relevant numerical values were described in this .docx file. (DOCX)</p

Table1_Case Report: Combined transcatheter arterial embolization and aortic stent-graft have better efficacy for bronchial artery aneurysms.docx

Bronchial artery aneurysm (BAA) is a rare and fatal condition that requires immediate treatment. However, conventional surgical and transcatheter arterial embolization treatments are less effective. In the present case, a 76-year-old hypertensive woman was admitted with dizziness and diagnosed with an unruptured bronchial artery aneurysm, which was treated by transcatheter arterial embolization and aortic stent-graft. The patient's clinical status was stable during the 4-year follow-up. Simultaneously, we reviewed 79 research papers, analyzing past BAA cases for their etiology, symptoms, and treatment outcomes. We found that catheter arterial embolization and aortic stent-graft implantation, especially for BAA of short-necked and arterial tortuosity, demonstrate superior efficacy compared to other methods. Therefore, we consider this approach to be the preferred choice in clinical BAA treatment.</p

Parallel alignments of designer yeast versus mammalian reporter assays.

A preliminary dose-dependent test for Fig 1C based on the readouts of ten indicated AR mutants (WT as control) in response to steroidal ligands. The OD600 values of liquid yeast cultures (without the presence of 3-AT) were measured 21 h post-incubation. Bars indicate mean ± s.d. (n = 2). (TIF)</p

Summary of sequenced AR mutations acquired in the secondary mutation library.

Summary of sequenced AR mutations acquired in the secondary mutation library.</p

A dose-dependent assay to determine the appropriate concentrations of tested ligands supplemented in the yeast medium in the presence of 25 mM 3-AT.

Plate pictures were taken 48 h post-incubation. (TIF)</p

Simulation of AR evolution by combining designer yeast with random mutagenesis.

(A) Characterization of the AR-LBD EP-PCR library. (B) Yeast clonal selection against compounds based on solid culture in 96-well plates without the presence of 3-AT. Ligands were 10−8 M DHT, 10−5 M PROG, 10−5 M E2, and 10−5 M CPA. The heatmap represents OD600 values of liquid cultures measured 21 h post-incubation. LBD-WT is indicated by pentacles; the × mark indicates blank wells. (C-D) Functional analysis of 19 identified AR mutations using both liquid (n = 6) and plate yeast assay in the presence of 3-AT against DHT 2 μM, E2 2 μM, PROG 2 μM, and CPA 2 μM. The incubation time was 60 h. Bars indicate mean ± s.d.</p