7 research outputs found
Bases anatomiques et physiologiques du traitement pariétal des péritonites graves et des éviscérations
No full textData-driven interdisciplinary mathematical modelling quantitatively unveils competition dynamics of co-circulating influenza strains
No full textEvaluating the Feasibility and Participants’ Representativeness of an Online Nationwide Surveillance System for Influenza in France
No full textB-cell responses to vaccination at the extremes of age
No full textInfants and the elderly share a high vulnerability to infections and therefore have specific immunization requirements. Inducing potent and sustained B-cell responses is as challenging in infants as it is in older subjects. Several mechanisms to explain the decreased B-cell responses at the extremes of age apply to both infants and the elderly. These include intrinsic B-cell limitations as well as numerous microenvironmental factors in lymphoid organs and the bone marrow. This Review describes the mechanisms that shape B-cell responses at the extremes of age and how they could be taken into account to design more effective immunization strategies for these high-risk age groups
