3 research outputs found
Synthesis of 2‑Aminobenzoxazoles and 3‑Aminobenzoxazines via Palladium-Catalyzed Aerobic Oxidation of <i>o</i>‑Aminophenols with Isocyanides
A Pd-catalyzed
aerobic oxidation of <i>o</i>-aminophenols and isocyanides
for the synthesis of 2-aminobenzoxazoles and 3-aminobenzoxazines has
been achieved in an air atmosphere. The procedure constructs 2-aminobenzoxazoles
and 3-aminobenzoxazines with moderate to excellent yields and a broad
substrate scope. Apart from experimental simplicity, this methodology
has the advantages of mild reaction conditions and easily accessible
starting materials. Furthermore, the utility of this method has also
been successfully applied to the synthesis of other types of useful
nitrogen heterocycles
Palladium-Catalyzed Intermolecular Aerobic Oxidative Cyclization of 2‑Ethynylanilines with Isocyanides: Regioselective Synthesis of 4‑Halo-2-aminoquinolines
A robust
and regioselective palladium-catalyzed intermolecular aerobic oxidative
cyclization of 2-ethynylanilines with isocyanides to the synthesis
of 4-halo-2-aminoquinolines is reported herein. The procedure constructs
various 4-halo-2-aminoquinolines with moderate to excellent yields
(47–94%) and broad substrates scope. Furthermore, this process
can be easily extended to synthesis of various 6<i>H</i>-indoloÂ[2,3-<i>b</i>]Âquinolines via an intramolecular Buchwald–Hartwig
cross-coupling reaction in two-step one-pot manner
Palladium-Catalyzed Intermolecular Aerobic Oxidative Cyclization of 2‑Ethynylanilines with Isocyanides: Regioselective Synthesis of 4‑Halo-2-aminoquinolines
A robust
and regioselective palladium-catalyzed intermolecular aerobic oxidative
cyclization of 2-ethynylanilines with isocyanides to the synthesis
of 4-halo-2-aminoquinolines is reported herein. The procedure constructs
various 4-halo-2-aminoquinolines with moderate to excellent yields
(47–94%) and broad substrates scope. Furthermore, this process
can be easily extended to synthesis of various 6<i>H</i>-indoloÂ[2,3-<i>b</i>]Âquinolines via an intramolecular Buchwald–Hartwig
cross-coupling reaction in two-step one-pot manner