Palladium-Catalyzed Intermolecular Aerobic Oxidative Cyclization of 2‑Ethynylanilines with Isocyanides: Regioselective Synthesis of 4‑Halo-2-aminoquinolines
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Abstract
A robust
and regioselective palladium-catalyzed intermolecular aerobic oxidative
cyclization of 2-ethynylanilines with isocyanides to the synthesis
of 4-halo-2-aminoquinolines is reported herein. The procedure constructs
various 4-halo-2-aminoquinolines with moderate to excellent yields
(47–94%) and broad substrates scope. Furthermore, this process
can be easily extended to synthesis of various 6<i>H</i>-indolo[2,3-<i>b</i>]quinolines via an intramolecular Buchwald–Hartwig
cross-coupling reaction in two-step one-pot manner