Harnessing the Power of Collaborative Filtering

China’s Internet development raises questions on the interplay of user autonomy and Internet governance in the larger Chinese-language online cultural sphere. To what extent has user autonomy been established to conduct information gatekeeping collaboratively online? To examine how the power of Chinese-language Internet users has been harnessed in relation to the filtering and censorship regime, the article applies the concept of “network gatekeeping” to analyse two major user-generated websites, Chinese Wikipedia and Baidu Baike, as different examples of collaborative filtering projects. Effectively they share “word-of-mouth” recommendations on encyclopaedic knowledge and information by user-contributors to edit content from different parts of the world. Two salient network gatekeeping mechanisms have emerged: the censorship mechanisms in Baidu Baike and internationalisation/localisation mechanisms in Chinese Wikipedia. The findings show a contrast between the two interaction patterns, indicating mainland-centric versus transnational Chinese gatekeeping processes employing different kinds of collaborative filtering and different levels of user autonomy

Le « filtrage collaboratif » comme gatekeeping

Le développement d’Internet en Chine soulève plusieurs questions relatives au rapport entre l’autonomie des utilisateurs et la gouvernance d’Internet dans la sphère culturelle de langue chinoise. Dans quelle mesure est-ce que l’autonomie des utilisateurs a été exploitée pour mettre en œuvre un contrôle collaboratif de l’information sur Internet ? Cet article applique le concept de network gatekeeping pour analyser deux encyclopédies en ligne, qui sont aussi deux exemples distincts de projets de filtrage collaboratif : la version chinoise de Wikipédia et Baidu Baike. Les deux sites ont pour objectif le partage de connaissances et d’informations encyclopédiques fournies et modifiées par des utilisateurs-contributeurs à travers le monde. Deux principaux types de mécanismes de network gatekeeping se dégagent : les mécanismes de censure pour Baidu Baike, et les mécanismes d’internationalisation/localisation pour Wikipédia en chinois. Notre enquête met en lumière les différences entre les deux modes d’interaction qui révèlent, d’un côté, une approche sinocentrique (centrée sur la République populaire de Chine) et, de l’autre, une approche transnationale. Ces deux modes utilisent différents types de filtrage collaboratif et se caractérisent par différents niveaux d’autonomie des utilisateurs

Analysing Geo-linguistic Dynamics of the World Wide Web: The Use of Cartograms and Network Analysis to Understand Linguistic Development in Wikipedia

This article discusses the usefulness of geo-linguistic analysis for Internet studies by presenting two techniques to frame and visualize the linguistic development of the World Wide Web, in particular the geo-linguistic development amongst different language versions of Wikipedia. An emergent research agenda has been set to explore the multilingual aspects of the Internet using, for example, a global perspective on Wikipedia research. And yet, there is a lack of theoretical and methodological tools for understanding the distribution and diffusion of linguistic materials online. The idea of geo-linguistic factors is introduced in this article to address these shortcomings and to respond to the study of a wide range of issues such as linguistic pluralism on the Internet or, more generally, the diffusion of innovation. Cartograms and network analysis are presented as two techniques that showcase the potential uses of geo-linguistic analysis. These two techniques of measurement and visualization indicate certain geographic and linguistic affiliations among languages. It is argued that although certain more developed language versions such as English and German may have central positions in connecting all languages, there exists another pattern that can best be explained by geo-linguistic factors. Finally, the limitations and implications of such findings and techniques are discussed, not only for research on Wikipedia but for Internet studies in general

Knowledge mapping of resilience and human rights in supply chains: A roadmapping taxonomy for twin green and digital transition design

Supply chain sustainability (SCS) has gone beyond the sustainability-performance approach, towards the increasing adoption of the sustainability-practice approach. The use of digital technologies in this approach can enhance resilience and human rights, particularly in the context of the green and digital twin transition post-COVID-19 pandemic. To enrich the sustainability-practice approach, this paper aims to produce a roadmapping taxonomy, based on knowledge mapping of a dataset collected in late December 2022 from the Web of Science Core Collection. As the knowledge map reveals the dimensions of resilience, human rights, and digital technologies, the proposed taxonomy highlights the importance of dynamic capabilities in facing supply chain disruptions, especially their ripple effects, along with the corresponding digital technologies to enhance human social dynamics in facing such disruptions. The proposed taxonomy provides a knowledge-based framework for professionals and researchers to enhance their understanding of supply chain resilience in designing and implementing digital solutions. The proposed roadmapping taxonomy features a people- and community-centric perspective and several managerial insights, contributing to the wider discussions on the green and digital transformation of the supply chain, by shaping actions and interactions in networked, digitized, and datafied forms to enhance supply chain sustainability

Collaborating on ESG consulting, reporting, and communicating education: Using partner maps for capability building design

Given the rising demand for environmental, social, and governance (ESG) talents, this study aims to provide a multidisciplinary outlook of specific capability requirements for ESG talents, focusing on the use of ESG and carbon information, thereby providing a roadmap for ESG education. Following design science framework conventions and running design workshops that integrate design thinking of “how might we” design questions, literature analysis, and expert interviews across disciplines, this study presents findings regarding three main activities—consulting, reporting, and communicating. Based on the iterations of design workshops that adopt a circular economy-based partner map design canvas for stakeholder analysis with procedures such as expert interviews and literature analysis, three partner/capability maps were generated to map stakeholders and explore the capabilities needed. ESG and carbon information digital and data skills emerged as the core capability to complete all the three tasks. A conceptual framework—a Smart System of ESG and Carbon Information—is proposed to summarize planning, operating, and communicating with ESG and carbon information, along with high-level organizational actions and talent capabilities. It identifies the building blocks of an ESG operating system within an enterprise to engage various stakeholders for value-creation collaboration. Despite the limitation of a lack of comprehensive review and limited geographic and disciplinary representation, this study provides a roadmap for enterprises and universities to explore and define talent requirements and create specific education and training programs

Humanizing Digital Literacies: A Road Trip in Search of Wisdom and Insight

Digital literacies abound in playing a foundational role in the rhythm and pattern of our lives, yet debates continue about how to harness them to teach and learn literacy. In an effort to humanize digital literacies, this department column offers a vast array of topics, from participatory work that pushes educators and researchers to communicate in local and global spaces to ways of redefining core reading and literacy skills through a screen‐based, multimodal logic. This column also provides a venue for research and practical applications that depict technology use as a part of the fabric of being human. The column helps educators reconceptualize the ways that children learn with technology, media, and new communication systems; honors educator success stories and burning questions and issues; and reimagines literacy futures

Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer

<p>Abstract</p> <p>Background</p> <p>P21^(WAF1/Cip1)binds to cyclin-dependent kinase complexes and inhibits their activities. It was originally described as an inhibitor of cancer cell proliferation. However, many recent studies have shown that p21 promotes tumor progression when accumulated in the cell cytoplasm. So far, little is known about the correlation between cytoplasmic p21 and drug resistance. This study was aimed to investigate the role of p21 in the cisplatin resistance of ovarian cancer.</p> <p>Methods</p> <p>RT-PCR, western blot and immunofluorescence were used to detect p21 expression and location in cisplatin-resistant ovarian cancer cell line C13* and its parental line OV2008. Regulation of cytoplasmic p21 was performed through transfection of p21 siRNA, Akt2 shRNA and Akt2 constitutively active vector in the two cell lines; their effects on cisplatin-induced apoptosis were evaluated by flow cytometry. Tumor tissue sections of clinical samples were analyzed by immunohistochemistry.</p> <p>Results</p> <p>p21 predominantly localizes to the cytoplasm in C13* compared to OV2008. Persistent exposure to low dose cisplatin in OV2008 leads to p21 translocation from nuclear to cytoplasm, while it had not impact on p21 localization in C13*. Knockdown of cytoplasmic p21 by p21 siRNA transfection in C13* notably increased cisplatin-induced apoptosis through activation of caspase 3. Inhibition of p21 translocation into the cytoplasm by transfection of Akt2 shRNA into C13* cells significantly increased cisplatin-induced apoptosis, while induction of p21 translocation into the cytoplasm by transfection of constitutively active Akt2 in OV2008 enhanced the resistance to cisplatin. Immunohistochemical analysis of clinical ovarian tumor tissues demonstrated that cytoplasmic p21 was negatively correlated with the response to cisplatin based treatment.</p> <p>Conclusions</p> <p>Cytoplasmic p21 is a novel biomarker of cisplatin resistance and it may represent a potential therapeutic target for ovarian tumors that are refractory to conventional treatment.</p

Mesenchymal stem cells as carriers and amplifiers in CRAd delivery to tumors

<p>Abstract</p> <p>Background</p> <p>Mesenchymal stem cells (MSCs) have been considered to be the attractive vehicles for delivering therapeutic agents toward various tumor diseases. This study was to explore the distribution pattern, kinetic delivery of adenovirus, and therapeutic efficacy of the MSC loading of E1A mutant conditionally replicative adenovirus Adv-Stat3(-) which selectively replicated and expressed high levels of anti-sense Stat3 complementary DNA in breast cancer and melanoma cells.</p> <p>Methods</p> <p>We assessed the release ability of conditionally replicative adenovirus (CRAd) from MSC using crystal violet staining, TCID₅₀assay, and quantitative PCR. In vitro killing competence of MSCs carrying Adv-Stat3(-) toward breast cancer and melanoma was performed using co-culture system of transwell plates. We examined tumor tropism of MSC by Prussian blue staining and immunofluorescence. In vivo killing competence of MSCs carrying Adv-Stat3(-) toward breast tumor was analyzed by comparison of tumor volumes and survival periods.</p> <p>Results</p> <p>Adv-Stat3(-) amplified in MSCs and were released 4 days after infection. MSCs carrying Adv-Stat3(-) caused viral amplification, depletion of Stat3 and its downstream proteins, and led to significant apoptosis in breast cancer and melanoma cell lines. In vivo experiments confirmed the preferential localization of MSCs in the tumor periphery 24 hours after tail vein injection, and this localization was mainly detected in the tumor parenchyma after 72 hours. Intravenous injection of MSCs carrying Adv-Stat3(-) suppressed the Stat3 pathway, down-regulated Ki67 expression, and recruited CD11b-positive cells in the local tumor, inhibiting tumor growth and increasing the survival of tumor-bearing mice.</p> <p>Conclusions</p> <p>These results indicate that MSCs migrate to the tumor site in a time-dependent manner and could be an effective platform for the targeted delivery of CRAd and the amplification of tumor killing effects.</p

The CDEX-1 1 kg Point-Contact Germanium Detector for Low Mass Dark Matter Searches

The CDEX Collaboration has been established for direct detection of light dark matter particles, using ultra-low energy threshold p-type point-contact germanium detectors, in China JinPing underground Laboratory (CJPL). The first 1 kg point-contact germanium detector with a sub-keV energy threshold has been tested in a passive shielding system located in CJPL. The outputs from both the point-contact p+ electrode and the outside n+ electrode make it possible to scan the lower energy range of less than 1 keV and at the same time to detect the higher energy range up to 3 MeV. The outputs from both p+ and n+ electrode may also provide a more powerful method for signal discrimination for dark matter experiment. Some key parameters, including energy resolution, dead time, decay times of internal X-rays, and system stability, have been tested and measured. The results show that the 1 kg point-contact germanium detector, together with its shielding system and electronics, can run smoothly with good performances. This detector system will be deployed for dark matter search experiments.Comment: 6 pages, 8 figure