The Luminosity Function of QSO Host Galaxies

We present some results from our HST archival image study of 71 QSO host galaxies. The objects are selected to have z < 0.46 and total absolute magnitude M_V < -23 (H_0=50 km/s/Mpc). This initial study investigates host morphology and radio loudness, and it derives the QSO host galaxy luminosity function. We have analyzed available WFPC2 broad band images, using a uniform set of procedures. The host galaxies span a narrow range of luminosities and are exceptionally bright, much more so than normal galaxies, usually L > L*_V. The QSOs are almost equally divided among radio-loud QSOs with elliptical hosts, radio-quiet QSOs with elliptical hosts, and radio-quiet QSOs with spiral hosts. Using a weighting procedure, we derive the combined luminosity function of QSO host galaxies. We find that the luminosity function of QSO hosts differs in shape from that of normal galaxies but that they coincide at the highest luminosities. The ratio of the number of quasar hosts to the number of normal galaxies at a luminosity L_V is R = [L_V/(11.48 L*_V)]^2.46, where L*_V corresponds to M*_V = -22.35, and a QSO is defined to be an object with total nuclear plus host light M_V < -23. This ratio can be interpreted as the probability that a galaxy with luminosity L_V will host a QSO at redshift z ~ 0.26. (Abridged)Comment: 36 pages, 11 figures, LaTeX. Expanded analysis and additional figures. To be published in the Astrophysical Journal, v576, September 1, 200

Water intoxication presenting as maternal and neonatal seizures: a case report.

Introduction We present an unusual case of fitting in the mother and newborn child, and the challenges faced in the management of their hyponatraemia due to water intoxication. Case presentation A previously well 37-year-old, primigravid Caucasian woman presented with features mimicking eclampsia during labour. These included confusion, reduced consciousness and seizures but without a significant history of hypertension, proteinuria or other features of pre-eclampsia. Her serum sodium was noted to be low at 111 mmol/litre as was that of her newborn baby. She needed anti-convulsants with subsequent intubation to stop the fitting and was commenced on a hypertonic saline infusion with frequent monitoring of serum sodium. There is a risk of long-term neurological damage from central pontine myelinolysis if the hyponatraemia is corrected too rapidly. Mother and baby went on to make a full recovery without any long-term neurological complications. Conclusion There is little consensus on the treatment of life-threatening hyponatraemia. Previous articles have outlined several possible management strategies as well as their risks. After literature review, an increase in serum sodium concentration of no more than 8–10 mmol/litre in 24 hours is felt to be safe but can be exceeded with extreme caution if life-threatening symptoms do not resolve. Formulae exist to calculate the amount of sodium needed and how much hypertonic intravenous fluid will be required to allow safer correction. We hypothesise the possible causes of hyponatraemia in this patient and underline its similarity in symptom presentation to eclampsia

Quasar Radio-Loudness and the Elliptical Core Problem

The dichotomy between radio-loud and radio-quiet QSOs is not simply one of host morphology. While spiral galaxies almost exclusively host radio-quiet QSOs, ellipticals can host either radio-louds or radio-quiets. We find that a combination of accretion rate and host scale determines which type of QSO a given elliptical galaxy will host. QSOs with high x-ray luminosities (above 10^44.5 erg/s at 0.5 keV) are mostly radio-loud. But those with low luminosities divide fairly neatly in size (measured by the half-light radius, r_e). Those larger than about 10 kpc are radio-loud, while smaller ones are radio-quiet. It has recently been found that core and coreless ellipticals are also divided near this limit. This implies that for low-luminosity QSOs, radio-louds are found in core ellipticals, while radio-quiets are in coreless ellipticals and spirals. This segregation also shows up strongly for low-redshift objects, and in general, there is a loss over time of coreless, radio-loud QSOs. Since the presence or absence of a core may be tied to the galactic merger history, we have an evolutionary explanation for the differences between radio-loud and radio-quiet QSOs.Comment: 8 pages, 4 figures. To be published in MNRA

Regulation of the human LAT gene by the Elf-1 transcription factor

BACKGROUND: The LAT gene encodes an intracellular adaptor protein that links cell-surface receptor engagement to numerous downstream signalling events, and thereby plays an integral role in the function of cell types that express the gene, including T cells, mast cells, natural killer cells, and platelets. To date, the mechanisms responsible for the transcriptional regulation of this gene have not been investigated. RESULTS: In this study we have mapped the transcriptional start sites for the human LAT gene and localized the 5' and 3' boundaries of the proximal promoter. We find that the promoter contains both positive and negative regulatory regions, and that two binding sites for the Ets family of transcription factors have a strong, positive effect on gene expression. Each site binds the Ets family member Elf-1, and overexpression of Elf-1 augments LAT promoter activity. The promoter also contains a Runx binding site adjacent to one of the Ets sites. This site, which is shown to bind Runx-1, has an inhibitory effect on gene expression. Finally, data is also presented indicating that the identified promoter may regulate cell-type specific expression. CONCLUSION: Collectively, these results provide the first insights into the transcriptional regulation of the LAT gene, including the discovery that the Ets transcription factor Elf-1 may play a central role in its expression

Adaptive-hybrid Redundancy with Error Injection

Adaptive-Hybrid Redundancy (AHR) shows promise as a method to allow flexibility when selecting between processing speed and energy efficiency while maintaining a level of error mitigation in space radiation environments. Whereas previous work demonstrated AHR’s feasibility in an error free environment, this work analyzes AHR performance in the presence of errors. Errors are deliberately injected into AHR at specific times in the processing chain to demonstrate best and worst case performance impacts. This analysis demonstrates that AHR provides flexibility in processing speed and energy efficiency in the presence of error

A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity

Many bacterial and viral pathogens (or their toxins), including Pseudomonas aeruginosa exotoxin A, require processing by host pro-protein convertases such as furin to cause disease. We report the development of a novel irreversible inhibitor of furin (QUB-F1) consisting of a diphenyl phosphonate electrophilic warhead coupled with a substrate-like peptide (RVKR), that also includes a biotin tag, to facilitate activity-based profiling/visualisation. QUB-F1 displays greater selectivity for furin, in comparison to a widely used exemplar compound (furin I) which has a chloromethylketone warhead coupled to RVKR, when tested against the serine trypsin-like proteases (trypsin, prostasin and matriptase), factor Xa and the cysteine protease cathepsin B. We demonstrate QUB-F1 does not prevent P. aeruginosa exotoxin A-induced airway epithelial cell toxicity; in contrast to furin I, despite inhibiting cell surface furin-like activity to a similar degree. This finding indicates additional proteases, which are sensitive to the more broad-spectrum furin I compound, may be involved in this process

Prevalence of microplastics and anthropogenic debris within a deep-sea food web

Microplastic particles (\u3c5 mm) are ubiquitous throughout global marine ecosystems, including the deep sea. Ingestion of microplastics and other anthropogenic microparticles is reported in diverse marine taxa across trophic levels. Trophic transfer, or the movement of microplastics across trophic levels, is reported in laboratory studies but not yet widely measured in marine food webs. The Monterey Bay submarine canyon ecosystem contains a well-studied, known deep-sea food web in which to examine the trophic fate of microplastics. We measured microplastic abundance across 17 genera spanning approximately 5 trophic levels and a diversity of feeding behaviors. Samples were collected using remotely operated vehicles and oblique midwater trawls, and gut contents of all individuals examined (n = 157) were analyzed for microplastic abundance and other anthropogenic particles greater than 100 μm using stereo microscopy. Microparticles were analyzed with Raman spectroscopy to confirm material type. Anthropogenic particles were found in all genera examined, across crustacean, fish, mollusk, and gelatinous organisms, in amounts ranging from 0 to 24 particles per individual. There was no significant relationship between microplastic amount and fish trophic level, suggesting that the trophic transfer of microparticles is not occurring. Body size was positively correlated with microplastic abundance across all taxa. The fish genus Scomber sp. drove this relationship, suggesting higher microparticle abundance in mobile individuals with broad horizontal distributions. Future work should examine physiological pathways for microplastic transport within organisms (e.g. excretion, accumulation on gills, internal translocation of particles) and between organisms within shared habitats to more fully understand the fate of microplastics within aquatic food webs

The Fundamental Plane of QSOs and the Relationship Between Host and Nucleus

We present results from an archival study of 70 medium-redshift QSOs observed with the Wide Field Planetary Camera 2 on board the Hubble Space Telescope. The QSOs have magnitudes M_V <= -23 (total nuclear plus host light) and redshifts $0.06 <= z <= 0.46$. The aim of the present study is to investigate the connections between the nuclear and host properties of QSOs, using high-resolution images and removing the central point source to reveal the host structure. We confirm that more luminous QSO nuclei are found in more luminous host galaxies. Using central black hole masses from the literature, we find that nuclear luminosity also generally increases with black hole mass, but it is not tightly correlated. Nuclear luminosities range from 2.3% to 200% of the Eddington limit. Those in elliptical hosts cover the range fairly evenly, while those in spirals are clustered near the Eddington limit. Using a principal components analysis, we find a kind of fundamental plane relating the nuclear luminosity to the size and effective surface magnitude of the bulge. Using optical nuclear luminosity, this relationship explains 96.1% of the variance in the overall sample, while another version of the relationship uses x-ray nuclear luminosity and explains 95.2% of the variance. The form of this QSO fundamental plane shows similarities to the well-studied fundamental plane of elliptical galaxies, and we examine the possible relationship between them as well as the difficulties involved in establishing this connection.Comment: 49 pages, 6 figures. Accepted by Ap