71 research outputs found

    Estimation of left ventricular end diastolic pressure (lvedp) in patients with ischemic heart disease by echocardiography and compare it with the results of cardiac catheterization

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    <strong>BACKGROUND:</strong> Doppler echocardiography has been proposed as an appropriate non-invasive<br />assay to estimate left ventricular end diastolic pressure (LVEDP). The aim of present research<br />was to estimate the LVEDP in patients with ischemic heart disease by echocardiography and<br />compare it with the results of cardiac catheterisation and to determine the effect of different<br />echocardiographic variables on its measurement.<br /><strong>METHODS:</strong> In this descriptive-analytic study, patients with diagnosed ischemic heart disease<br />were selected by nonrandomized sampling method. Selected population underwent M-mode<br />and pulse doppler echocardiographic evaluation and parameters such as Q-Mitral valve E<br />(Q-MVE), Q-Aortic valve closure (Q-AVC), Aortic valve closure-E (AVC-E), Q-Mitral valve<br />closure/Aortic valve closure-E (Q-MVC/AVC-E), left ventricle-deceleration time (LV-DT), peak<br />velocity-deceleration time (PV-DT) and A/E velocity time integral (A/E VTI) were evaluated.<br />Immediately after echocardiography all patients underwent left heart catheterization for LVEDP<br />measurement. The relation between different echocardiographic measurements and LVEDP,<br />obtained by cardiac catheterization, was evaluated.<br /><strong>RESULTS:</strong> In this study, 47 patients with ischemic heart disease with mean age (&plusmn;SD) of<br />53 &plusmn; 13 were studied. There was a significant correlation between LVDEP and A/E VTI (r=0.44,<br />P = 0.001, and also between LVEDP and PV-DT in patients with A/E VTI &ge;1.1(r = -0.58, P = 0.02).<br />There was a significant correlation between LVEDP and Q-MVC/AVC-E in patients with LVEDP<br />&gt;18mmHg (r = 0.76, P= 0.03) and those with LVEDP &le;18 mmHg and A/E VTI &lt; 1.1<br />(r = 0.37, P= 0.03). The correlation between LVEDP and A/E VTI was more significant in men,<br />in patients aged &gt; 50 years with EF &gt; 55%, without LVH, without MR and those with coronary<br />artery disease (P &lt; 0.05).<br /><strong>CONCLUSION:</strong> Some echocardiographic indices such as A/E VTI, Q-MVC/AVC-E and PV-DT<br />are able to measure LVEDP especially in male patients aged &gt; 50 years, without LVH, without<br />MR and those with coronary artery disease but it is necessary to determine specific conditions<br />and factors affecting these indices, by further studies.<br /><strong>Keywords:</strong> LVEDP, Coronary Artery Disease, Echocardiography

    Correlation Between Body Fat Distribution, Plasma Lipids and Apolipoproteins with the Severity of Coronary Involvement in Patients with Stable Angina

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    <p class="abstract"><strong>BACKGROUND:</strong> Previous studies reported that the distribution of body fat is an important risk factor for coronary artery diseases (CAD) and abdominal adipose tissue is associated with severe CAD. This study was conducted to evaluate the relationship between body fat distributions, plasma lipids and the severity of CAD in patients with stable angina.</p> <p class="abstract"><strong>&nbsp;&nbsp; METHODS:</strong><strong> </strong>Ninety seven patients who underwent coronary angiography for stable angina were allocated into two groups: patients with mild or sever coronary artery involvement. Lipid profile (total cholesterol, LDL, HDL) and triglyceride (TG) and apolipoprotein A and B, were measured for all of the participants and a demographic data questionnaire was filled by the subjects. Participants underwent abdominal computed tomography (CT-Scan) for measurement of adipose tissues that was classified to visceral and superficial and deep subcutaneous fat tissue compartment.</p> <p class="abstract"><strong>&nbsp;&nbsp; RESULTS:</strong> Patients with severe coronary artery involvement had higher level of apo B <br /> (P = 0.02). Significant correlation was seen between visceral fat index and TG (P = 0.01), HDL-C (P &lt; 0.01) in patients with mild coronary involvement and with total cholesterol (P = 0.02), LDL-C (P = 0.01) and apoB (P &lt; 0.01) in patients with severe coronary involvement .No significant relationship was seen among deep cutaneous fat index and lipid profile in both groups.<strong></strong></p> <p class="abstract"><strong>&nbsp;&nbsp; </strong><strong>CONCLUSION:</strong> Our findings showed that visceral adipose tissue is significantly associated with severe CAD and has a significant correlation with lipid profile as well as Apo B.</p><p class="abstract"><strong>Keywords:</strong> Visceral Abdominal Adipose Tissue, Superficial Subcutaneous Adipose Tissue, Deep Subcutaneous Adipose Tissue, Coronary Involvement, Lipid Profile.</p

    Diagnostic performance of 64-row coronary CT angiography in detecting significant stenosis as compared with conventional invasive coronary angiography

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    BACKGROUND: The aim of the present study is to evaluate the accuracy of 64-multidetector-row computed tomography angiography (CTA) in comparison to conventional invasive angiography (CIA) in the diagnosis of significant stenosis (≥ 50) of coronary artery tree. METHODS: Assessment of CTA in the detection of coronary artery disease (CAD) was performed in patients referred because of symptoms or stress studies suggestive of ischemia. For this purpose, among more than 1000 cases of coronary CTA in a 20 months period a study population of 54 patients suspected to have significant stenosis of the coronary artery tree was investigated. The CIA procedure was performed in these patients one month after CTA. The accuracy of CTA in detecting significant stenosis was compared to CIA. RESULTS: For vessel based analysis of 179 coronary vessels, CTA had a sensitivity of 96, specificity of 87.5, positive predictive value of 90.5, and negative predictive value of 94.6. For patient-base analysis, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of CTA were 97.9, 28.6, 66.6, and 90.2, respectively. CONCLUSION: The findings of this study reveal that CT angiography with 64-slice scanner could be considered as a suitable technique for rapid triage of patients presenting to hospitals with chest pain. High values of sensitivity and PPV reveal the good performance of CTA in detecting CAD

    Intrahepatic Artery Pseudoaneurysm as a Delayed Presentation of Blunt Abdominal Trauma

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    Arterial pseudoaneurysm is an uncommon life-threatening complication in blunt trauma patients. Blunt liver injury may lead to hepatic artery pseudoaneurysm. Radiological intervention is the method of choice in diagnosis and treatment of hepatic artery pseudoaneurysm. However, surgical intervention is advised for unstable patients with large leaking defects. This study reports a case of 53-year-old female who was admitted with vague abdominal pain. She had experienced a blunt abdominal trauma a year ago and had gone under liver packing procedure. The CT-scan results showed hematoma in RUQ region and leaking pseudoaneurysm of right hepatic artery. Hematoma was drained and partial liver resection and hepatic arterioraphy were done through laparotomy

    Evaluation of Leptin and Adiponectin Levels in Patients with Stable Angina Pectoris

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    <p class="abstract"><strong>BACKGROUND:</strong> Leptin and adiponectin are two adipose tissue hormones and their association with the incidence of cardiovascular diseases is under evaluation. The aim of this study was to determine the relationship of leptin and adiponectin with coronary artery diseases.</p> <p class="abstract"><strong>&nbsp;&nbsp; METHODS:</strong><strong> </strong>One hundred and seventy patients with angina pectoris and indications of coronary angiography underwent angiography. Serum levels of blood lipids, leptin, and adiponectin were measured. The gathered data was evaluated using SPSS software, V. 15, by multivariate variance analysis.</p> <p class="abstract"><strong>&nbsp;&nbsp; RESULTS:</strong> Analysis of the data demonstrated that 45.1% of the patients had positive angiographic findings. The serum levels of leptin and adiponectin were significantly lower than the minimum levels specified by the kit. However, the two groups, i.e., patients with positive angiographic findings and those with negative findings were not significantly different according to the serum levels of the hormones. Moreover, no significant correlation between the serum levels of the hormones and serum lipids was observed.<strong>&nbsp;</strong></p> <p class="abstract"><strong>&nbsp;&nbsp; </strong><strong>CONCLUSION:</strong> Various studies have demonstrated that high serum level of leptin and the incidence of coronary artery diseases are correlated. On the other hand, they have reported that adiponectin has cardioprotective role. Confirmation of these findings requires more detailed studies.</p> <p class="abstract">&nbsp;</p><table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td width="35" height="12"><br /></td></tr> <tr><td><br /></td> <td>&nbsp;</td></tr></tbody></table><strong>Keywords:</strong> Leptin, Adiponectin, Coronary artery disease<br /

    Association of brain Magnetic Resonance Imaging (MRI) findings with the histopathologic grading of brainstem glioma

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    To determine association of brainstem glioma’s grading with brain magnetic resonance imaging (MRI) findings

    INDENTER TIP DEPENDENCE IN THE DETERMINATION OF ELASTIC MODULUS IN POLYMERS

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    ABSTRACT The two most common outputs of nanoindentation experiment are hardness and elastic modulus. Length scale dependent deformation in polymers has however been observed in different experiments such as microbeam bending, torsional thin wires and indentation testing which may affect the mechanical testing. Unlike in metals where the size dependency is attributed to necessary geometry dislocations, the origin of length scale dependent deformation in polymers is not well understood. In this study, elastic modulus of polydimethylsiloxane (PDMS) is determined using both Berkovich and spherical tips. Observing different trends for elastic modulus upon the change of indentation depth using these two different tips brings up the question which tip should be used to get the real mechanical properties of PDMS which is discussed here. Surface roughness, surface effects and the imperfection of the Berkovich indenter tip are negligible at the studied length scale

    Razonamiento de los estudiantes acerca de la probabilidad en el contexto de una rifa

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    III Congreso Internacional Virtual de Educación Estadística (CIVEEST), 21-24 febrero de 2019. [www.ugr.es/local/fqm126/civeest.html]Assessing students’ conceptions related to independence and probability has been the focus of research in probability education for over 40 years. While we know a lot from past studies about predictable ways students may reason with well-known tasks, developing a diagnostic assessment that can be used by teachers to inform instruction demands the use of familiar and unfamiliar contexts. This paper presents the current work of a research team whose aim is to create a valid formative assessment that uses a psychometric model to confidently predict the presence of a misconception or conception across many items. The focus in this paper is on the evolution of one item and the difficulty it presents in accurately diagnosing students’ conceptions of independence.La evaluación de las concepciones de los estudiantes relacionadas con la independencia y la probabilidad ha sido el foco de la investigación en la enseñanza de la probabilidad por más de 40 años. Si bien sabemos mucho de los últimos estudios sobre las maneras predecibles en que pueden razonar los estudiantes con tareas bien conocidas, desarrollar una evaluación de diagnóstico que pueda ser utilizada por los maestros para informar la instrucción exige el uso de contextos familiares y desconocidos. Este documento presenta el trabajo actual de un equipo de investigación cuyo objetivo es crear una evaluación formativa válida que utiliza un modelo psicométrico que permita predecir con confianza la presencia de una concepción errónea a través de muchos ítems. En el presente trabajo trata de la evolución de un ítem y la dificultad que presenta para el diagnóstico con precisión de las concepciones de los estudiantes sobre la independencia

    Can Timi Risk Score Predict Angiographic Involvement in Patients with St-Elevation Myocardial Infarction?

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    <p class="abstract"><strong>BACKGROUND:</strong> In most studies, the agreeable risk scores for ST-elevation myocardial infarction (STEMI) consist of thrombolytic in myocardial infarction (TIMI) risk score and modified Gensini risk score. Researchers showed significant relations between TIMI with angiography scores in patients with UA/NSTEMI. We studied this relation in patients with STEMI.</p> <p class="abstract"><strong>&nbsp;&nbsp; METHODS:</strong><strong> </strong>We studied CCU patients with STEMI hospitalized in several hospitals of Isfahan, Iran from September 2007 to June 2008. Sampling method of 240 patients was random and simple. Exclusion criteria were incomplete history, nonspecific electrocardiogram changes, left bundle branch block and not accomplished angiography or accomplished angiography after 2 months of STEMI. Questionnaire indices collected on the basis of TIMI (0-14 points). Echocardiography and angiography were done and then, we used Gensini (0-400 points) to review films of angiography. Spearman`s rank test and Pearson correlation coefficient were used to study the relation between these scores.</p> <p class="abstract"><strong>&nbsp;&nbsp; RESULTS:</strong> One hundred and sixty one patients were male and their average age was 60.02 years. Averages of TIMI and Gensini scores were 6.30 &plusmn; 2.5 and 120.77 &plusmn; 50.4, respectively. Study showed significant relation between TIMI, age and LVEF (P &lt;0.001, r=-0.46). Also, between Gensini and age, gender and LVEF significant relation was found (P &lt;0.001). But, a meaningful correlation didn&rsquo;t exist between TIMI and the gender (P =0.08). Our study proved direct relation between TIMI risk scores and modified Gensini scores (P &lt;0.001, r=0.55).<strong>&nbsp;</strong></p> <p class="abstract"><strong>&nbsp;&nbsp; </strong><strong>CONCLUSION:</strong> We may decide quickly and correctly in emergency room to distinguish which patients with STEMI could derive a benefit from invasive strategies using TIMI score. Also, TIMI risk score can be a good predictor to determine the extension of coronary artery disease in patients with STEMI. As a result, we suggest determination of TIMI score for any patient entered emergency room. Also, this score should be recorded at the time patient&rsquo;s discharge.</p> <table cellspacing="0" cellpadding="0" align="left"><tbody><tr><td width="35" height="12">&nbsp;</td></tr><tr><td><br /></td> <td>&nbsp;</td></tr></tbody></table><p class="abstract"><strong>Keywords:</strong> TIMI Risk Score, Modified Gensini Risk Score, LVEF, STEMI.</p

    Clinical Study The Effects of Beta-Glucan Rich Oat Bread on Serum Nitric Oxide and Vascular Endothelial Function in Patients with Hypercholesterolemia

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    Introduction. Oats are high in soluble fibers and effective in reducing the risk of cardiovascular diseases (CVD). We assessed the effects of beta-glucan from oat bran on serum nitric oxide (NO) endothelial function in patients with hypercholesterolemia. Method. Sixty hypercholesterolemic patients were randomly divided to receive an experimental bread rich in beta-glucan from oat bran (intervention) or bread rich in wheat fiber (control) for four weeks. All subjects had the same diet for two-week baseline period and hypocaloric diet for four weeks of intervention. Serum NO concentration and flow-mediated dilation (FMD) were determined before and after the experiment. Results. Mean age of the participants was 51.1 ± 9.3 years and 65% ( = 39) were female. After intervention, serum NO concentration increased by 50.2 ± 19.8 mol/lit in the intervention group ( = 0.017), but no change was observed in the control group (17.5 ± 27.5 mol/lit; = 0.530). No change of FMD was observed in the intervention (0.48 ± 0.78%; = 0.546) or in the control group (0.59 ± 0.92%; = 0.533). Conclusion. Consumption of oat bread for four weeks increases serum NO concentration but has no effect on FMD. Further studies are warranted in this regard
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