Observation of the astrophysically important 3+ state in 18Ne via elastic scattering of a radioactive 17F beam from 1H

The 17F(p, γ)18 reaction is important in stellar explosions, but its rate has been uncertain because of an expected 3+ state in 18Ne that has never been conclusively observed. This state would provide a strong l = 0 resonance and, depending on its excitation energy, could dominate the stellar reaction rate. We have observed this missing 3+ state by measuring the 1H(17F, p)17F excitation function with a radioactive 17F beam at the ORNL Holifield Radioactive Ion Beam Facility. We find that the state lies at a center-of-mass energy of Er = 599.8 ± 1.5stat ± 2.0sys keV (Ex = 4523.7 ± 2.9keV) and has a width of Γ = 18 ± 2stat ± 1sys keV

The astrophysically important 3+ state in 18Ne and the 17F(py)18Ne stellar rate

Knowledge of the [Formula Presented] reaction rate is important for understanding stellar explosions, but it was uncertain because the properties of an expected but previously unobserved [Formula Presented] state in [Formula Presented] were not known. This state would provide a strong s-wave resonance for the [Formula Presented] system and, depending on its excitation energy, could dominate the stellar reaction rate at temperatures above 0.2 GK. We have observed this missing [Formula Presented] state by measuring the [Formula Presented] excitation function with a radioactive [Formula Presented] beam at the ORNL Holifield Radioactive Ion Beam Facility (HRIBF). We find that the state lies at a center-of-mass energy of [Formula Presented] keV [Formula Presented] and has a width of [Formula Presented] The measured properties of the resonance are only consistent with a [Formula Presented] assignment

Effect of apomorphine on cognitive performance and sensorimotor gating in humans

Contains fulltext : 88792.pdf (publisher's version ) (Closed access)INTRODUCTION: Dysfunction of brain dopamine systems is involved in various neuropsychiatric disorders. Challenge studies with dopamine receptor agonists have been performed to assess dopamine receptor functioning, classically using the release of growth hormone (GH) from the hindbrain as primary outcome measure. The objective of the current study was to assess dopamine receptor functioning at the forebrain level. METHODS: Fifteen healthy male volunteers received apomorphine sublingually (2 mg), subcutaneously (0.005 mg/kg), and placebo in a balanced, double-blind, cross-over design. Outcome measures were plasma GH levels, performance on an AX continuous performance test, and prepulse inhibition of the acoustic startle. The relation between central outcome measures and apomorphine levels observed in plasma and calculated in the brain was modeled using a two-compartmental pharmacokinetic-pharmacodynamic analysis. RESULTS: After administration of apomorphine, plasma GH increased and performance on the AX continuous performance test deteriorated, particularly in participants with low baseline performance. Apomorphine disrupted prepulse inhibition (PPI) on high-intensity (85 dB) prepulse trials and improved PPI on low intensity (75 dB) prepulse trials, particularly in participants with low baseline PPI. High cognitive performance at baseline was associated with reduced baseline sensorimotor gating. Neurophysiological measures correlated best with calculated brain apomorphine levels after subcutaneous administration. CONCLUSION: The apomorphine challenge test appears a useful tool to assess dopamine receptor functioning at the forebrain level. Modulation of the effect of apomorphine by baseline performance levels may be explained by an inverted U-shape relation between prefrontal dopamine functioning and cognitive performance, and mesolimbic dopamine functioning and sensorimotor gating. Future apomorphine challenge tests preferentially use multiple outcome measures, after subcutaneous administration of apomorphine.1 januari 201

Communication-Efficient Cluster Scalable Genomics Data Processing Using Apache Arrow Flight

Current cluster scaled genomics data processing solutions rely on big data frameworks like Apache Spark, Hadoop and HDFS for data scheduling, processing and storage. These frameworks come with additional computation and memory overheads by default. It has been observed that scaling genomics dataset processing beyond 32 nodes is not efficient on such frameworks.To overcome the inefficiencies of big data frameworks for processing genomics data on clusters, we introduce a low-overhead and highly scalable solution on a SLURM based HPC batch system. This solution uses Apache Arrow as in-memory columnar data format to store genomics data efficiently and Arrow Flight as a network protocol to move and schedule this data across the HPC nodes with low communication overhead.As a use case, we use NGS short reads DNA sequencing data for pre-processing and variant calling applications. This solution outperforms existing Apache Spark based big data solutions in term of both computation time (2x) and lower communication overhead (more than 20-60% depending on cluster size). Our solution has similar performance to MPI-based HPC solutions, with the added advantage of easy programmability and transparent big data scalability. The whole solution is Python and shell script based, which makes it flexible to update and integrate alternative variant callers. Our solution is publicly available on GitHub at https://github.com/abs-tudelft/time-to-fly-high/tree/main/genomicsGreen Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Computer Engineerin

OCTUPOLE EXCITATIONS IN VIBRATIONAL NUCLEI AND THE SDF INTERACTING BOSON MODEL

Proton and deuteron inelastic scattering experiments, performed with an energy resolution of 12-15 keV, have been used to study negative-parity states of vibrational and transitional nuclei with mass between 98 and 150. The analysis has been focussed on the isovector components, on the quadrupole-octupole two-phonon states and on the fragmentation of the octupole strength. This latter displays a regular dependence on the product of proton and neutron valence particle numbers and is satisfactorily reproduced by IBM-1+f-boson calculations. Other features of the experimental spectra, as the relative positions of the 3- states, exhibit a dependence on the ratio of valence particle numbers and indicate that a IBM-2 approach might be more appropriate