Tailoring the carrier mobility of semiconducting nanowires by remote dielectrics

The dielectric environment of thin semiconductor nanowires can affect the charge transport properties inside the wire. In this work, it is shown that Coulomb impurity scattering inside thin nanowires can be damped strongly by coating the wire with a high-k dielectric. This will lead to an increase in the mobility of free charges inside the wire.Comment: 4 pages, 3 figure

In Vivo Intracellular Oxygen Dynamics in Murine Brain Glioma and Immunotherapeutic Response of Cytotoxic T Cells Observed by Fluorine-19 Magnetic Resonance Imaging

Noninvasive biomarkers of anti-tumoral efficacy are of great importance to the development of therapeutic agents. Tumor oxygenation has been shown to be an important indicator of therapeutic response. We report the use of intracellular labeling of tumor cells with perfluorocarbon (PFC) molecules, combined with quantitative 19F spin-lattice relaxation rate (R1) measurements, to assay tumor cell oxygen dynamics in situ. In a murine central nervous system (CNS) GL261 glioma model, we visualized the impact of Pmel-1 cytotoxic T cell immunotherapy, delivered intravenously, on intracellular tumor oxygen levels. GL261 glioma cells were labeled ex vivo with PFC and inoculated into the mouse striatum. The R1 of 19F labeled cells was measured using localized single-voxel magnetic resonance spectroscopy, and the absolute intracellular partial pressure of oxygen (pO2) was ascertained. Three days after tumor implantation, mice were treated with 2×107 cytotoxic T cells intravenously. At day five, a transient spike in pO2 was observed indicating an influx of T cells into the CNS and putative tumor cell apoptosis. Immunohistochemistry and quantitative flow cytometry analysis confirmed that the pO2 was causally related to the T cells infiltration. Surprisingly, the pO2 spike was detected even though few (∼4×104) T cells actually ingress into the CNS and with minimal tumor shrinkage. These results indicate the high sensitivity of this approach and its utility as a non-invasive surrogate biomarker of anti-cancer immunotherapeutic response in preclinical models. © 2013 Zhong et al

Low-supervision urgency detection and transfer in short crisis messages

Humanitarian disasters have been on the rise in recent years due to the effects of climate change and socio-political situations such as the refugee crisis. Technology can be used to best mobilize resources such as food and water in the event of a natural disaster, by semi-automatically flagging tweets and short messages as indicating an urgent need. The problem is challenging not just because of the sparseness of data in the immediate aftermath of a disaster, but because of the varying characteristics of disasters in developing countries (making it difficult to train just one system) and the noise and quirks in social media. In this paper, we present a robust, low-supervision social media urgency system that adapts to arbitrary crises by leveraging both labeled and unlabeled data in an ensemble setting. The system is also able to adapt to new crises where an unlabeled background corpus may not be available yet by utilizing a simple and effective transfer learning methodology. Experimentally, our transfer learning and low-supervision approaches are found to outperform viable baselines with high significance on myriad disaster datasets.Comment: 8 pages, short version published in ASONAM 201

Green's function approach to transport through a gate-all-around Si nanowire under impurity scattering

We investigate transport properties of gate-all-around Si nanowires using non-equilibrium Green's function technique. By taking into account of the ionized impurity scattering we calculate Green's functions self-consistently and examine the effects of ionized impurity scattering on electron densities and currents. For nano-scale Si wires, it is found that, due to the impurity scattering, the local density of state profiles loose it's interference oscillations as well as is broaden and shifted. In addition, the impurity scattering gives rise to a different transconductance as functions of temperature and impurity scattering strength when compared with the transconductance without impurity scattering.Comment: 8 pages, 4 figure

Energy partitioning on intermolecular interactions: ab initio Monte Carlo study of water dimer

Ab initio Monte Carlo computations were carried out on H₂O dimer system. By introducing the energy partitioning scheme that we have developed recently, ab initio calculated H₂O–H₂O interaction can be analyzed from the viewpoint of atom-atom interaction. The electronic polarization caused by the interaction and its temperature dependence are also discussed. To our best knowledge, this is the first report on the thermal distribution of electronic distortion energy assigned to a molecule.Виконанi ab initio Монте Карло розрахунки для H2O димерної системи. Вводячи розроблену ранiше схему роздiлення енергiї, ab initio розрахована взаємодiя H2O–H2O може бути проаналiзована з точки зору атом-атомної взаємодiї. Обговорюється електронна поляризацiя, обумовлена взаємодiєю, та її температурна залежнiсть. З точки зору наших вiдомостей, це є перше повiдомлення про термiчний розподiл електронної змiни енергiї, переданої молекулi

Sensitivity of cosmic-ray experiments to ultra-high-energy photons: reconstruction of the spectrum and limits on the superheavy dark matter

We estimate the sensitivity of various experiments detecting ultra-high-energy cosmic rays to primary photons with energies above 10^19 eV. We demonstrate that the energy of a primary photon may be significantly (up to a factor of ~ 10) under- or overestimated for particular primary energies and arrival directions. We consider distortion of the reconstructed cosmic-ray spectrum for the photonic component. As an example, we use these results to constrain the parameter space of models of superheavy dark matter by means of both the observed spectra and available limits on the photon content. We find that a significant contribution of ultra-high-energy particles (photons and protons) from decays of superheavy dark matter is allowed by all these constraints.Comment: 18 pages, 7 figure

Exchange interaction effects in inter-Landau level Auger scattering in a two-dimensional electron gas

We consider the influence of spin effects on the inter-Landau level electron-electron scattering rate in a two-dimensional electron gas. Due to the exchange spin splitting, the Landau levels are not equidistant. This leads to the suppresion of Auger processes and a nonlinear dependence of the lifetime on the concentration of the excited electrons even at very low excitation levels.Comment: 10 pages, 3 figure