Local earthquake tomography of the Erzincan Basin and the surrounding area in Turkey

In this study, selected travel time data from the aftershock series of the Erzincan earthquake (March, 1992, Ms=6.8) were inverted simultaneously for both hypocenter locations and 3D Vp and Vs structure. The general features of the 3D velocity structure of the upper crust of Erzincan Basin and the surrounding area, one of the most tectonically and seismically active regions in Turkey were investigated. The data used for this purpose were 2215 P-wave and 547 S-wave arrival times from 350 local earthquakes recorded by temporary 15 short-period seismograph stations. Thurbers simultaneous inversion method (1983) was applied to the arrival time data to obtain a 3D velocity structure, and hypocentral locations. Both 3D heterogeneous P and S wave velocity variations down to 12 km depth were obtained. The acquired tomographic images show that the 3D velocity structure beneath the region is heterogeneous in that low velocity appears throughout the basin and at the southeastern flank, and high velocities occur at south and east of the basin. The low velocities can be related to small and large scale fractures, thus causing rocks to weaken over a long period of the active tectonic faulting process. The ophiolitic rock units mostly occurring around the basin area are the possible reason for the high velocities. The validity of 3D inversion results was tested by performing detailed resolution analysis. The test results confirm the velocity anomalies obtained from inversion. Despite the small number of inverted S-wave arrivals, the obtained 3D S velocity model has similar anomalies with lower resolution than the 3D P-wave velocity model. Better hypocenter locations were calculated using the 3D heterogeneous model obtained from tomographic inversion

The possibility of using fluid whey in comminuted meat products: capacity and viscosity of the model emulsions prepared using whey and muscle proteins

The emulsion capacity (EC) of whey and sarcoplasmic proteins were low when they were used alone, but the EC and viscosity (EV) of total meat proteins (TMP) were higher than those values of other proteins investigated, including a combination of whey plus TMP. However, the solubility of the TMP proteins was lower than that of the other proteins investigated, probably due to the differences in the physico-chemical properties of whey and muscle proteins and the buffer used. In general, EC of whey proteins showed a significant alteration when used in combination with muscle proteins, while its solubility was not changed. The present results suggest that it is possible to use fluid whey in emulsion-type meat products and these studies should continue using actual meat emulsion systems. © 1995 Springer-Verlag

Effects of CO2-H2O dilution on the characteristics of CH4-air-O2 flames

International audience Study of non-premixed turbulent flames stabilized by a swirler Control of pollutant emissions / emissions standards Improve performances of combustion plants Investigations on flame characteristics Effects of oxygen enrichment Effects of steam and CO2 dilution Effects of swirl intensit

Multi-criteria evaluation of hydrogen and natural gas fuelled power plant technologies

This paper evaluates nine types of electrical energy generation options with regard to seven criteria. The options use natural gas or hydrogen as a fuel. The Analytic Hierarchy Process was used to perform the evaluation, which allows decision-making when single or multiple criteria are considered. The options that were evaluated are the hydrogen combustion turbine, the hydrogen internal combustion engine, the hydrogen fuelled phosphoric acid fuel cell, the hydrogen fuelled solid oxide fuel cell, the natural gas fuelled phosphoric acid fuel cell, the natural gas fuelled solid oxide fuel cell, the natural gas turbine, the natural gas combined cycle and the natural gas internal combustion engine. The criteria used for the evaluation are CO2 emissions, NOX emissions, efficiency, capital cost, operation and maintenance costs, service life and produced electricity cost. A total of 19 scenarios were studied. In 15 of these scenarios, the hydrogen turbine ranked first and proved to be the most preferred electricity production technology. However since the hydrogen combustion turbine is still under research, the most preferred power generation technology which is available nowadays proved to be the natural gas combined cycle which ranked first in five scenarios and second in eight. The last in ranking electricity production technology proved to be the natural gas fuelled phosphoric acid fuel cell, which ranked in the last position in 13 scenarios

Male–female differences in quality of life and coping style in patients with Marfan syndrome and hereditary thoracic aortic diseases

Hereditary thoracic aortic diseases (HTAD) such as Marfan syndrome (MFS) affect multiple organ systems and provide a risk of acute aortic dissection, which causes lifelong uncertainties. Although health-related quality of life (HRQOL) was found to be reduced in HTAD patients, no studies have evaluated male–female-specific aspects of HRQOL and coping in this population. This study aims to evaluate HRQOL in HTAD patients compared to the general population; assess male–female differences in HRQOL and factors associated with HRQOL; evaluate coping styles in male and female HTAD patients and identify factors associated with acceptance. All consecutive adult patients who visited the specialized HTAD outpatient clinic between 2013 and 2018 were asked to complete three HRQOL questionnaires: the Short Form 36 (SF-36), the Hospital Anxiety and Depression Scale (HADS), and the Nijmegen Clinical Screening Instrument (NCSI). In total, 142 patients were included (mean age 42.1 years, 65 females, 123 MFS). Compared to the general population, HTAD patients scored significantly lower on multiple SF-36 sub-domains (males: General Health 54.5 ± 18.8 vs. 71.6 ± 20.6, p <.001; Vitality 58.3 ± 20.4 vs. 71.9 ± 18.3, p <.001; females: Physical Functioning 67.5 ± 23.8 vs. 80.4 ± 24.2, p =.003; Role Physical 58.3 ± 45.1 vs. 73.8 ± 38.5, p =.047; General Health 49.4 ± 24.3 vs. 69.9 ± 20.6, p <.001; Social Functioning 73.5 ± 22.0 vs. 82.0 ± 23.5, p =.027). Females scored significantly lower than males on the SF-36 physical component score (41.6 [IQR 35.5–53.1] vs. 49.3 [IQR 42.3–54.6], p =.035). Males scored significantly higher on the coping style denial than females (2.75 [IQR 2.00–3.25] vs. 2.25 [IQR 1.75–3.25], p =.018). High scores on acceptance were found in 38 (26.8%) of HTAD patients, and these patients showed significantly better scores on the NCSI, SF-36, and HADS, except on NCSI Satisfaction Relationships and SF-36 Physical Functioning and Mental Health. Acceptance was associated with more medication use (beta blocker use, p =.008; angiotensin receptor blocker use, p =.003) and less hypertension (p =.001). In patients with MFS, employment was strongly associated with better scores on the NCSI. In conclusion, HTAD patients showed subnormal HRQOL, especially females. Interestingly, in both males and females factors such as employment, coping style, and disease acceptance seem more important for HRQOL than disease-related factors. This highlights the importance of genetic counseling and guidance for HTAD patients, and offers valuable leads for HRQOL improvement

Male-Female Differences in Acute Type B Aortic Dissection

BACKGROUND: Acute type B aortic dissection is a cardiovascular emergency with considerable mortality and morbidity risk. Male-female differences have been observed in cardiovascular disease; however, literature on type B aortic dissection is scarce. METHODS AND RESULTS: A retrospective cohort study was conducted including all consecutive patients with acute type B aortic dissection between 2007 and 2017 in 4 tertiary hospitals using patient files and questionnaires for late morbidity. In total, 384 patients were included with a follow-up of 6.1 (range, 0.02-14.8) years, of which 41% (n=156) were female. Women presented at an older age than men (67 [interquartile range (IQR), 57-73] versus 62 [IQR, 52-71]; P=0.015). Prior abdominal aortic aneurysm (6% versus 15%; P=0.009), distally extending dissections (71 versus 85%; P=0.001), and clinical malperfusion (18% versus 32%; P=0.002) were less frequently observed in women. Absolute maximal descending aortic diameters were smaller in women (36 [IQR: 33-40] mm versus 39 [IQR, 36-43] mm; P&lt;0.001), while indexed for body surface area diameters were larger in women (20 [IQR, 18-23] mm/m2 versus 19 [IQR, 17-21] mm/m2). No male-female differences were found in treatment choice; however, indications for invasive treatment were different (P&lt;0.001). Early mortality rate was 9.6% in women and 11.8% in men (P=0.60). The 5-year survival was 83% (95% CI, 77-89) for women and 84% (95% CI, 79-89) for men (P=0.90). No male-female differences were observed in late (re)interventions. CONCLUSIONS: No male-female differences were found in management, early or late death, and morbidity in patients presenting with acute type B aortic dissection, despite distinct clinical profiles at presentation. More details on the impact of age and type of intervention are warranted in future studies.</p

Male-Female Differences in Acute Type B Aortic Dissection

BACKGROUND: Acute type B aortic dissection is a cardiovascular emergency with considerable mortality and morbidity risk. Male-female differences have been observed in cardiovascular disease; however, literature on type B aortic dissection is scarce. METHODS AND RESULTS: A retrospective cohort study was conducted including all consecutive patients with acute type B aortic dissection between 2007 and 2017 in 4 tertiary hospitals using patient files and questionnaires for late morbidity. In total, 384 patients were included with a follow-up of 6.1 (range, 0.02-14.8) years, of which 41% (n=156) were female. Women presented at an older age than men (67 [interquartile range (IQR), 57-73] versus 62 [IQR, 52-71]; P=0.015). Prior abdominal aortic aneurysm (6% versus 15%; P=0.009), distally extending dissections (71 versus 85%; P=0.001), and clinical malperfusion (18% versus 32%; P=0.002) were less frequently observed in women. Absolute maximal descending aortic diameters were smaller in women (36 [IQR: 33-40] mm versus 39 [IQR, 36-43] mm; P&lt;0.001), while indexed for body surface area diameters were larger in women (20 [IQR, 18-23] mm/m2 versus 19 [IQR, 17-21] mm/m2). No male-female differences were found in treatment choice; however, indications for invasive treatment were different (P&lt;0.001). Early mortality rate was 9.6% in women and 11.8% in men (P=0.60). The 5-year survival was 83% (95% CI, 77-89) for women and 84% (95% CI, 79-89) for men (P=0.90). No male-female differences were observed in late (re)interventions. CONCLUSIONS: No male-female differences were found in management, early or late death, and morbidity in patients presenting with acute type B aortic dissection, despite distinct clinical profiles at presentation. More details on the impact of age and type of intervention are warranted in future studies.</p

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity

Primary immunodeficiency disorders enable identification of genes with crucial roles in the human immune system. Here we study patients suffering from recurrent bacterial, viral and Cryptosporidium infections, and identify a biallelic mutation in the MAP3K14 gene encoding NIK (NF- B-inducing kinase). Loss of kinase activity of mutant NIK, predicted by in silico analysis and confirmed by functional assays, leads to defective activation of both canonical and non-canonical NF- B signalling. Patients with mutated NIK exhibit B-cell lymphopenia, decreased frequencies of class-switched memory B cells and hypogammaglobulinemia due to impaired B-cell survival, and impaired ICOSL expression. Although overall T-cell numbers are normal, both follicular helper and memory T cells are perturbed. Natural killer (NK) cells are decreased and exhibit defective activation, leading to impaired formation of NK-cell immunological synapses. Collectively, our data illustrate the non-redundant role for NIK in human immune responses, demonstrating that loss-of-function mutations in NIK can cause multiple aberrations of lymphoid immunity