457 research outputs found
Biological Role of Anions (Sulfate, Nitrate , Oxalate and Acetate) on the Antibacterial Properties of Cobalt (II) and Nickel(II) Complexes With Pyrazinedicarboxaimide Derived, Furanyl and Thienyl Compounds
A number of biologically active complexes of cobalt(II) and nickel(II) with pyrazinedicarboxaimido derived
thienyl and furanyl compounds having the same metal ion but different anions such as sulphate, nitrate,
oxalate and acetate have been synthesized and characterized on the basis of their physical, spectral and
analytical data. In order to evaluate the role of anions on their antibacterial properties, these ligands and
their synthesized metal complexes with various anions have been screened against bacterial species
Escherichia coil,Pseudomonas aeruginosa and Staphylococcus aureus. The title studies have proved a definitive role of anions in increasing the antibacterial properties
4-[(E)-(5-Chloro-2-hydroxybenzylidene)amino]benzenesulfonamide
In the molecule of title compound, C13H11ClN2O3S, the aromatic rings are oriented at a dihedral angle of 12.27 (3)°. An intramolecular O—H⋯N hydrogen bond results in the formation of a planar (mean deviation 0.0083 Å) six-membered ring, which is nearly coplanar with the adjacent ring at a dihedral angle of 2.36 (13)°. In the sulfonamide group, the S atom is 0.457 (3) Å from the plane through the O and N atoms. In the crystal structure, intermolecular N—H⋯O hydrogen bonds link the molecules
Structural and Biological Behaviour of Co(II), Cu(II) and Ni(II) Metal Complexes of Some Amino Acid Derived Schiff-Bases
Biologically active tridentate amino acid (Alanine, Glycine & Tyrosine) derived Schiff-bases and their Co(II), Cu(II) & Ni(II) complexes have been synthesised and characterised
on the basis of their conductance and magnetic measurements, elemental analysis and 13C-NMR, 1H-NMR, IR and electronic spectral data. These Schiff-bases and their complexes have been evaluated for their antibacterial activity against bacterial species such as Staphylococcus aureus, Escherichia coli, Klebsiella pneumonae, Proteus vulgarus and Pseudomonas aeruginosa and this activity data show the metal complexes to be more
antibacterial than the Schiff-bases against one or more bacterial species
Synthesis, Characterization and Biological Properties of Anions of Bivalent Transition Metal [Co(II) and Ni(II)] Complexes With Acylhydrazine Derived ONO Donor Schiff Bases
Some acylhydrazine derived ONO donor Schiff bases and their Co(II) and Ni(II) complexes have been prepared having the same metal ion (cation) but different anions. These synthesized metal(II) complexes have been characterized on the basis of their elemental analyses, magnetic moment, molar conductance, and IR and electronic spectral data. All of the Schiff base ligands function as tridentates and the deprotonated enolic form is preferred for coordination. In order to evaluate the effect of anions on the bactericidal activity, these synthesized complexes, in comparison to the uncomplexed Schiff bases have been screened against bacterial species., Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the results are reported
N-[(E)-(5-Methylthiophen-2-yl)methylidene]-1H-1,2,4-triazol-3-amine
In the title Schiff base, C8H8N4S, a condensation product of 5-methylthiophene-2-carboxaldehyde and 3-amino-1,2,4-triazole, the dihedral angle between the triazolyl and thienyl rings is 6.44 (14)°. The compound exists as a polymeric chain arising from intermolecular N—H⋯N bonding
Copper (II) Acylhydrazinates. Their Synthesis and Characterization
Acylhydrazine derived furanyl and thienyl Schiff bases and their Cu(II) complexes have been prepared and
characterized on the basis of their physical, spectral and analytical data. The preferred enolic form of the
Schiff base function as a tetradentate ligand during coordination to the metal ion yielding a square planar
complex. The Schiff bases and their complexes with different anions were tested for their antibacterial
activity against bacterial species such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa
andKlebsiella pneumonae
Metal-Based Antibacterial and Antifungal Agents: Synthesis, Characterization, and In Vitro Biological Evaluation of Co(II), Cu(II), Ni(II), and Zn(II) Complexes With Amino Acid-Derived Compounds
A series of antibacterial and antifungal amino acid-derived compounds and their cobalt(II), copper(II), nickel(II), and zinc(II) metal complexes have been synthesized and characterized by their elemental analyses, molar conductances, magnetic moments, and IR, and electronic spectral measurements. Ligands (L(1))−(L(5)) were derived by condensation of β-diketones with glycine, phenylalanine, valine, and histidine and act as bidentate towards metal ions (cobalt, copper, nickel, and zinc) via the azomethine-N and deprotonated-O of the respective amino acid. The stoichiometric reaction between the metal(II) ion and synthesized ligands in molar ratio of M : L (1 : 1) resulted in the formation of the metal complexes of type [M(L)(H(2)O)(4)]Cl (where M = Co(II), Cu(II), and Zn(II)) and of M : L (1 : 2) of type [M(L)(2)(H(2)O)(2)] (where M = Co(II), Cu(II), Ni(II), and Zn(II)). The magnetic moment data suggested for the complexes to have an octahedral geometry around the central metal atom. The electronic spectral data also supported the same octahedral geometry of the complexes. Elemental analyses and NMR spectral data of the ligands and their metal(II) complexes agree with their proposed structures. The synthesized ligands, along with their metal(II) complexes, were screened for their in vitro antibacterial activity against four Gram-negative (Escherichia coli, Shigella flexeneri, Pseudomonas aeruginosa, and Salmonella typhi) and two Gram-positive (Bacillus subtilis and Staphylococcus aureus) bacterial strains and for in vitro antifungal activity against Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani, and Candida glaberata. The results of these studies show the metal(II) complexes to be more antibacterial/antifungal against one or more species as compared to the uncomplexed ligands. The brine shrimp bioassay was also carried out to study their in vitro cytotoxic properties. Five compounds, (3), (7), (10), (11), and (22), displayed potent cytotoxic activity as LD(50) = 8.974 × 10(−4), 7.022 × 10(−4), 8.839 × 10(−4), 7.133 × 10(−4), and 9.725 × 10(−4) M/mL, respectively, against Artemia salina
Non-invasive single-bunch matching and emittance monitor
On-line monitoring of beam quality for high brightness beams is only possible
using non-invasive instruments. For matching measurements, very few such
instruments are available. One candidate is a quadrupole pick-up. Therefore, a
new type of quadrupole pick-up has been developed for the 26 GeV Proton
Synchrotron (PS) at CERN, and a measurement system consisting of two such
pick-ups is now installed in this accelerator. Using the information from these
pick-ups, it is possible to determine both injection matching and emittance in
the horizontal and vertical planes, for each bunch separately. This paper
presents the measurement method and some of the results from the first year of
use, as well as comparisons with other measurement methods.Comment: 10 pages, 10 figures; added figure, minor textual additions; To be
resubmitted to Phys. Rev. ST-A
Synthesis, Ligational and Biological Properties of Cobalt(II), Copper(II), Nickel(II) and Zinc(II) Complexes With Pyrazinedicarboxaimide Derived Furanyl, Thienyl and Pyrrolyl Compounds
Preparation, ligational and biological properties of some pyrazinedicarboxaimide derived
furanyl, thienyl and pyrrolyl compounds with Co(ll), Cu(ll), Ni(ll) and Zn(ll) metals are
described. Magnetic moments, electronic, infrared, nuclear magnetic resonance spectra and
elemental analysis data indicate that co-ordination of the ligands with the metal ions take
place through the pyrazine ring nitrogen, azomethine nitrogen and heteroatom of
heterocyclic ring system. The compounds are all novel and are proposed to possess an
octahedral geometry for Co(ll) and Ni(ll), and a distorted octahedral geometry for Cu(ll) and
Zn(ll) complexes. The comparative biological properties of the title ligands and their metal
chelates against different bacterial species are also described
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