A novel predictor parameter for active recurrent aphthous stomatitis: C-Reactive protein to albumin ratio

*Kayabaşı, Serkan ( Aksaray, Yazar ) *Çayır, Serkan ( Aksaray, Yazar )Objective Laboratory analysis results may provide an opportunity to predict the activity process of recurrent aphthous stomatitis. The goal of this study was to investigate whether there is a correlation between C-reactive protein to albumin ratio (CAR) and oral ulcer activity in patients with recurrent aphthous stomatitis. Materials and methods We included 72 patients (39 with active and 33 with inactive lesion) with recurrent aphthous stomatitis and 60 healthy controls. We compared blood test parameters including CAR, white blood cell count (WBC) and neutrophil to lymphocyte ratio (NLR) among the groups. Additionally, we investigated the most significant parameter for the activity of oral ulcers. Results NLR was significantly higher both in the active (p<0.001) and inactive lesion groups (p<0.001), compared to the control group but did not significantly differ between active and inactive lesion groups (pm3.17). A significant difference in median CAR (p<0.001) and WBC (p<0.001) was evident among the three groups. Median WBC was significantly higher in the active lesion group compared to the control group (p<0.001) but did not significantly differ between active and inactive lesion groups (p=0.095). Median CAR was significantly higher in the active lesion group, compared both to the inactive lesion group (p=0.002) and the control group (p<0.001). Median CAR was also significantly higher in the inactive lesion group compared to the control group (p<0.001). Median hemoglobin, platelet to lymphocyte ratio and mean platelet volume did not significantly differ among three groups (p=0.16, p=0.85, p=0.19, respectively). Conclusion CAR could be used as a predictive parameter for inflammation and activity of oral ulcers in patients with recurrent aphthous stomatitis...

Os efeitos do tempo de cirurgia intradia na dor e ansiedade de pacientes submetidos à septoplastia

Kayabaşı, Serkan ( Aksaray, Yazar ) Çayır, Serkan ( Aksaray, Yazar )Introduction: Anxiety and pain levels of septoplasty patients may vary according to intraday operation time. Objective: To investigate the effects of septoplasty operation and intraday operation time on anxiety and postoperative pain. Methods: Ninety- eight voluntary patients filled out the hospital anxiety and depression scale to measure the anxiety level three weeks before, one hour before and one week after surgery. Forty-nine patients were operated at 8:00 am (morning group); other 49 were operated at 03:00 pm (afternoon group). We used a visual analogue scale to measure postoperative pain. Preoperative and postoperative scores were compared, as were the scores of the groups. Results: Median hospital anxiety and depression scale scores one hour before the operation [6 (2–10)] were significantly higher compared to the median scores three weeks before the operation [3 (1–6)] (p < 0.001), and one week after the operation [2 (1–6)] were significantly lower compared to the median scores three weeks before the operation [3 (1–6)] (p < 0.001). Hospital anxiety and depression scale scores one hour before the operation were significantly greater in the afternoon group [8 (7–10)], compared to the morning group [4 (2–6)] (p < 0.001). Postoperative first, sixth, twelfth and twenty-fourth-hour pain visual analogue scale scores were significantly higher in the afternoon group compared to the morning group (p < 0.001). Conclusion: Septoplasty might have an increasing effect on short-term anxiety and postoperative pain. Performing this operation at a late hour in the day might further increase anxiety and pain. However, the latter has no long-term effect on anxiety

Does surgical treatment of nasal airway obstruction improve sexual functions?

*Çayır, Serkan ( Aksaray, Yazar ) *Gül, Murat ( Aksaray, Yazar )Objective To investigate the effects of surgical treatment for nasal obstruction on sexual functions, regardless of the condition causing the nasal obstruction.Methods Of 238 patients identified with nasal obstruction, 57 complained of erectile dysfunction and were included in the analysis. Patients underwent septoplasty, functional endoscopic sinus surgery, concha bullosa excision or radiofrequency ablation of the inferior turbinates, depending on their obstruction-causing disease. Pre-and post-operative evaluation of perceived nasal obstruction was performed using the Nasal Obstruction Symptom Evaluation questionnaire. Pre-and post-operative assessment of sexual functions was performed using the International Index of Erectile Function.Results Mean post-operative scores for erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall sexual satisfaction were significantly higher compared to the pre-operative scores (p = 0.022, p = 0.036, p = 0.033, p = 0.016 and p = 0.029, respectively).Conclusion Surgical treatment of nasal obstruction by septoplasty, endoscopic sinus surgery, concha bullosa excision or radiofrequency can significantly improve sexual performance...

Does paranasal sinus development affect olfactory fossa depth and lateral lamella length?

Objectives: To investigate the olfactory fossa depths and lateral lamella lengths of patients with different types of developmental disorders of paranasal sinuses in comparison with normal controls. Study Design: Retrospective, archival, radio-anatomical study. Methods: We included 58 patients with maxillary sinus hypoplasia, 50 patients with frontal sinus hypoplasia/aplasia, 50 patients with sphenoid sinus hypoplasia/aplasia, and 40 normal controls. Reviewing paranasal computerized tomography scans, we noted the olfactory fossa depths and lateral lamella lengths of all the groups and compared between the hypoplasia groups and the control group. Results: Compared with the normal controls, the maxillary hypoplasia group (P < 0.001), frontal hypoplasia/aplasia group (P = 0.004), and sphenoid hypoplasia/aplasia group had significantly deeper olfactory fossa (P = 0.003). The mean lateral lamella lengths in the type 1, type 2, and type 3 hypoplastic maxillary sinus groups were significantly greater compared with that in the control group (P < 0.001). Additionally, the mean lateral lamella lengths in the hypoplastic frontal sinus, aplastic frontal sinus, and hypoplastic sphenoid sinus groups were significantly greater compared with that in the control group (P < 0.001). Conclusion: The patients with pneumatization defects of the maxillary, frontal, and sphenoid sinuses had deeper olfactory fossa and longer lateral lamella related to increased risk of skull base injury during endoscopic sinus surgery. Level of Evidence: 3 Laryngoscope, 2019. © 2019 The American Laryngological, Rhinological and Otological Society, Inc

Is C-reactive protein to albumin ratio an indicator of poor prognosis in Bell's palsy?

*Çayır, Serkan ( Aksaray, Yazar ) *Kayabaşı, Serkan ( Aksaray, Yazar )Purpose The aim of this study was to determine whether the C-reactive protein to albumin ratio was associated with the prognosis in patients with Bell's palsy. Methods Reviewing records of 79 patients diagnosed with Bell's palsy, 3 groups were constituted: recovered group (with a House Brackman grade of 1 or 2 after treatment, 56 patients), unrecovered group (23 patients) and control group (60 healthy individuals). Age, hemoglobin, C-reactive protein to albumin ratio, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, white blood cell and hemoglobin values were compared among the groups. Results Age, hemoglobin and platelet to lymphocyte ratio were not significantly different between the groups (p = 0.12, p = 0.31, p = 0.86 and p = 0.87, respectively). Median C-reactive protein to albumin ratio, neutrophil to lymphocyte ratio and white blood cell were significantly greater both in non-recovery group (p < 0.001) and recovery group (p = 0.001 and p < 0.001, respectively) compared to the control group. Additionally, median C-reactive protein to albumin ratio and neutrophil to lymphocyte ratio were significantly greater in the non-recovery group, compared to the recovery group (p = 0.002, and p < 0.001, respectively). However, median white blood cell did not significantly differ between the non-recovery and the recovery groups (p = 0.89). Conclusion Higher C-reactive protein to albumin ratio and neutrophil to lymphocyte ratio were associated with poor prognosis in patients with Bell's palsy. C-reactive protein to albumin ratio might be the most significant indicator of poor prognosis in patients with Bell's palsy...

Parâmetros preditores de mau prognóstico em pacientes com perda auditiva neurossensorial súbita: relação fibrinogênio/albumina vs. relação proteina C-reativa/albumina

*Çayır, Serkan ( Aksaray, Yazar ) *Kayabaşı, Serkan ( Aksaray, Yazar )Introduction: Prognosis of sudden sensorineural hearing loss may be predicted using several parameters of laboratory blood analysis. Objective: To identify and investigate the most significant indicator parameters related to the poor prognosis of sudden sensorineural hearing loss. Methods: Eighty-eight patients were included, and three groups were constituted: non-recovery group with14 patients, recovery group with 33 patients and control group with 41 individuals. We compared fibrinogen-to-albumin ratio, C-reactive protein-to-albumin ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, white blood cell and hemoglobin of the groups. Then, we investigated the most significant indicator parameters related to the poor prognosis of sudden hearing loss. Results: The mean hemoglobin, mean platelet-lymphocyte ratio and median white blood cell values did not significantly differ among three groups (p = 0.36, p = 0.86 and p = 0.79, respectively). A significant difference of median fibrinogen-albumin ratio, C-reactive protein-albumin ratio, neutrophil-to-lymphocyte ratio was evident among three groups (p < 0.001, p = 0.003 and p = 0.002, respectively). Median fibrinogen-albumin ratio, C-reactive protein-albumin ratio and neutrophil-to-lymphocyte ratio values were significantly greater in the non-recovery group, compared with the controls (p < 0.001, p = 0.003 and p = 0.005, respectively). Median fibrinogen-to-albumin ratio, C-reactive protein-to-albumin ratio and neutrophil-to-lymphocyte ratio were significantly greater in the recovery group, compared with the controls (p < 0.001, p = 0.013 and p = 0.005, respectively). Moreover, the median fibrinogen-albumin ratio was significantly greater in the non-recovery group compared with the recovery group (p = 0.017). However, no statistically significant difference of median C-reactive protein-albumin ratio, neutrophil-to-lymphocyte was evident between the non-recovery and recovery groups (p = 0.15). Conclusion: Increased levels of fibrinogen-albumin ratio may be predictive for poor prognosis in patients with sudden sensorineural hearing loss

Is snoring sound a cause of noise- induced hearing loss?

*Kayabaşı, Serkan ( Aksaray, Yazar )Purpose: The traumatic effects of intense snoring sound on the cochlea of snoring patient are still unclear. The aim of this study was to investigate whether snoring sound over 65 dB caused a perceivable hearing loss in snoring patients. Method: We included 72 patients with a pre- diagnosis of sleep apnea. To investigate the effects of snoring sound, we constituted two groups by reference to the max snoring sound level: lower snoring sound group (≤65 dB) and higher snoring sound group (>65 dB). We compared audiology parameters and the ratios of presence of a pure- tone threshold shift over 20 dB at every single frequency of both ears between these groups. Results: Compared with lower snoring sound group, the median thresholds at 250, 500, 1000, 2000, 4000 and 8000 Hz; pure- tone averages and speech recognition threshold values were significantly higher in the right ears of high snoring sound group (p<0.001, p=0.004) as were in the left ears (p<0.001, p=0.005). The ratios of presence of a pure- tone threshold over 20 dB at 4000 Hz and 8000 Hz were significantly higher in high snoring sound group both for right (p=0.002 for 4000 Hz, p=0.001 for 8000 Hz) and left ears (p=0.002 for 4000 Hz, p<0.001 for 8000 Hz). Conclusion: Snoring sound over 65 dB might negatively affect hearing functions in patients with sleep apnea, causing a perceivable hearing loss (threshold increase over 20 dB) at 4000 Hz and 8000 Hz

Is type 1 tympanoplasty effective in elderly patients? Comparison of fascia and perichondrium grafts

*Çayır, Serkan ( Aksaray, Yazar ) *Kayabaşı, Serkan ( Aksaray, Yazar )Background: Tympanoplasty is regularly performed in various ages but data about the procedure in elderly is insufficient. Objectives: To compare the success rates and hearing outcomes of fascia and perichondrium grafts used for tympanoplasty in patients >65 years and to evaluate the prognostic factors affecting the success of tympanoplasty. Methods: Reviewing records of 49 elderly patients underwent tympanoplasty, two groups were constituted: perichondrium (25 patients) and fascia (24 patients) groups. Ages, genders, perforation sides, type and location of perforation, graft success rates, functional success rates and air–bone gap (ABG) gains were compared. Results: Overall graft success rate was 85.7%. After a mean follow-up of 23.3 ± 8.32 months, overall mean ABG gain was 11.33 ± 8.42 dB. Overall median postoperative ABG value (9 dB) was significantly lower compared to the median preoperative value (24 dB) (p <.001). Graft success rate was higher in perichondrium group (96%) compared to fascia group (75%) (p =.04). Functional success rate did not significantly differ between perichondrium (68%) and fascia groups (62.5%) (p =.68). Conclusion and significance: Tympanoplasty is an effective procedure with a graft success rate of 85.7% in elderly. Both fascia and perichondrium are suitable materials; however, perichondrium had higher success rate...

The association between obstructive sleep apnea and hearing loss: a cross-sectional analysis

Purpose: To determine if sleep apnea had significant effects on hearing functions and to investigate the polysomnography parameters that might be associated with hearing impairment in sleep apnea patients. Methods: We included 120 patients who were admitted to sleep disorders outpatient clinic. We constituted four groups by reference to the apnea–hypopnea index (including control group), and compared the audiometric parameters of the groups. Additionally, we investigated the correlation of apnea–hypopnea index, desaturation index and min. oxygen saturations with pure-tone thresholds, speech recognition thresholds and speech discrimination scores. Results: The median pure-tone thresholds at 250, 500, 1000, 2000, 4000 and 8000 mHz, the median speech recognition thresholds and the median speech discrimination scores on both ears did significantly differ among four groups (p < 0.001). Moderate sleep apnea affected high-frequency hearing functions and speech discrimination scores, and severe sleep apnea had significant effects on all hearing functions. Pure-tone thresholds and speech recognition thresholds on the both ears were positively correlated with apnea–hypopnea index and desaturation index, and negatively correlated with min. oxygen saturation (p < 0.001). Speech discrimination scores on the both ears were negatively correlated with apnea–hypopnea index and desaturation index, and positively correlated with min. oxygen saturation (p < 0.001). Conclusion: Obstructive sleep apnea syndrome (OSA) had several effects on hearing, and hearing impairment might be associated with the severity of OSA. Moderate OSA affected high-frequency hearing functions and severe OSA affected all hearing functions negatively. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature

Is Nasal Septal Body Size Associated With Inferior Turbinate Hypertrophy and Allergic Rhinitis?

Özkan, Deniz ( Aksaray, Yazar )Nasal septal body is a thickened mucosal area of nasal septum with an unknown certain role. In this study, the authors aimed to investigate the association between the area, length, and width of the nasal septal body with inferior turbinate hypertrophy (ITH) and allergic rhinitis (AR). A total of 106 patients with ITH (54 with AR and 52 without AR), and 49 patients without ITH and AR (control group) were included in this study. Using axial and coronal paranasal computed tomography scans, the area, length, and width of nasal septal body were measured, and the mean values between the groups were compared. Mean area, length, and width of nasal septal body significantly differed among 3 groups (P < 0.001). Septal body area was significantly greater in ITH with AR group, compared to ITH without AR group (P < 0.001) and the control group (P < 0.001). Also, it was significantly greater in ITH without AR group compared to the control group (P < 0.001). Septal body width was significantly greater in ITH with AR group, compared to ITH without AR group (P < 0.001) and the control group (P < 0.001). Also, it was significantly greater in ITH without AR group compared to the control group (P < 0.001). Patients with ITH had a greater nasal septal body area, length, and width, compared to the patients without. Moreover, AR had an additional increasing effect on the area and width of the nasal septal body