4,478 research outputs found
Memorable And Secure: How Do You Choose Your PIN?
Managing all your PINs is difficult. Banks acknowledge this by allowing and facilitating PIN
changes. However, choosing secure PINs is a difficult task for humans as they are incapable of
consciously generating randomness. This leads to certain PINs being chosen more frequently
than others, which in turn increases the danger of someone else guessing correctly. We
investigate different methods of supporting PIN changes and report on an evaluation of these
methods in a study with 152 participants. Our contribution is twofold: We introduce an
alternative to system-generated random PINs, which considers people’s preferred
memorisation strategy, and, secondly, we provide indication that presenting guidance on how
to avoid insecure PINs does indeed nudge people towards more secure PIN choices when they
are in the process of changing their PINs
Real-time dynamics of clusters. III. I_2Ne_n (n=2–4), picosecond fragmentation, and evaporation
In this paper (III) we report real-time studies of the picosecond dynamics of iodine in Ne clusters I*2Nen(n = 2–4) --> I*2 + nNe. The results are discussed in relation to vibrational predissociation (VP), basic to the I2X systems, and to the onset of intramolecular vibrational-energy redistribution (IVR). The latter process, which is a precursor for the evaporation of the host atoms or for further fragmentation, is found to be increasingly effective as the cluster size increases; low-energy van der Waals modes act as the accepting (bath) modes. The reaction dynamics for I2Ne2 are examined and quantitatively compared to a simple model which describes the dynamics as consecutive bond breaking. On this basis, it is concluded that the onset of energy redistribution is observed in I2Ne2. Comparison of I2Ne and I2Ne2 to larger clusters (n=3,4) is accomplished by introducing an overall effective reaction rate. From measurements of the rates and their dependence on v[script ']i, the initial quantum number of the I2 stretch, we are able to examine the dynamics of direct fragmentation and evaporation, and compare with theory
Real-time dynamics of clusters. II. I_2X_n (n=1; X=He, Ne, and H_2), picosecond fragmentation
In this second paper (II) of a series, we report our picosecond time-resolved studies of the state-to-state rates of vibrational predissociation in iodine–rare gas (van der Waals) clusters. Particular focus is on the simplest system, I2He, which serves as a benchmark for theoretical modeling. Comparisons with I2Ne and I2H2 are also presented. The results from measurements made in real time are compared with those deduced from linewidth measurements, representing a rare example of a system studied by both methods under identical conditions and excited to the same quantum (v[script ']i) states. The discrepancies are discussed in relation to the origin of the broadening and preparation of the state. The rates as a function of v[script ']i display a nonlinear behavior which is examined in relation to the energy-gap law. The measured absolute rates and their dependence on v[script ']i are compared with numerous calculations invoking classical, quantum, and semiclassical theories. In the following paper (III in this series), the cluster size of the same system, I2Xn, is increased (n=2–4) and the dynamics are studied
Solar power satellite rectenna design study: Directional receiving elements and parallel-series combining analysis
Rectenna conversion efficiencies (RF to dc) approximating 85 percent were demonstrated on a small scale, clearly indicating the feasibility and potential of efficiency of microwave power to dc. The overall cost estimates of the solar power satellite indicate that the baseline rectenna subsystem will be between 25 to 40 percent of the system cost. The directional receiving elements and element extensions were studied, along with power combining evaluation and evaluation extensions
Reproducibility of cognitive endpoints in clinical trials: Lessons from neurofibromatosis type 1
OBJECTIVE: Rapid developments in understanding the molecular mechanisms underlying cognitive deficits in neurodevelopmental disorders have increased expectations for targeted, mechanism-based treatments. However, translation from preclinical models to human clinical trials has proven challenging. Poor reproducibility of cognitive endpoints may provide one explanation for this finding. We examined the suitability of cognitive outcomes for clinical trials in children with neurofibromatosis type 1 (NF1) by examining test-retest reliability of the measures and the application of data reduction techniques to improve reproducibility.
METHODS: Data were analyzed from the STARS clinical trial (n = 146), a multi-center double-blind placebo-controlled phase II trial of lovastatin, conducted by the NF Clinical Trials Consortium. Intra-class correlation coefficients were generated between pre- and post-performances (16-week interval) on neuropsychological endpoints in the placebo group to determine test-retest reliabilities. Confirmatory factor analysis was used to reduce data into cognitive domains and account for measurement error.
RESULTS: Test-retest reliabilities were highly variable, with most endpoints demonstrating unacceptably low reproducibility. Data reduction confirmed four distinct neuropsychological domains: executive functioning/attention, visuospatial ability, memory, and behavior. Test-retest reliabilities of latent factors improved to acceptable levels for clinical trials. Applicability and utility of our model was demonstrated by homogeneous effect sizes in the reanalyzed efficacy data.
INTERPRETATION: These data demonstrate that single observed endpoints are not appropriate to determine efficacy, partly accounting for the poor test-retest reliability of cognitive outcomes in clinical trials in neurodevelopmental disorders. Recommendations to improve reproducibility are outlined to guide future trial design
Simultaneous fitting of X-ray and neutron diffuse scattering data
Conventional crystallographic refinement uses the Bragg-peak intensities and gives the single-site average crystal structure. Information about short-range order and local order is contained in the diffuse scattering that is distributed throughout reciprocal space. Models of the short-range order in materials can now be automatically refined. The complementarity of X-ray and neutron diffraction data, and the value of simultaneously refining a structural model against both types of data, has long been known. This paper presents the first refinement of a short-range-order model against comprehensive X-ray and neutron diffuse scattering data simultaneously. The sample is the organic molecular crystal benzil, C14H10O2 (for neutron work H is replaced by D). The technique gives new insights into local order in crystalline materials, including the dynamic correlation structure indicative of the dynamics of molecules in the crystalline state, and successfully overcomes limitations of using only the X-ray data set
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